| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Madagascar: Escape 2 Africa | $654,209 | -30.9% | 111 | +100 | $5,893 | $5,284,940 | 5 | Universal Pictures International (UPI) | false | false |
| 2 | - | Yes Man | $587,538 | - | 102 | - | $5,760 | $595,134 | 1 | Warner Bros. | true | false |
| 3 | 2 | Loft | $289,126 | -35.3% | 32 | -1 | $9,035 | $7,931,153 | 11 | Independent Films | false | false |
| 4 | 3 | Australia | $249,744 | -36.4% | 102 | - | $2,448 | $1,175,379 | 3 | 20th Century Fox International | false | false |
| 5 | 6 | Twilight | $242,860 | -24.6% | 54 | - | $4,497 | $1,958,925 | 6 | Belga Films | false | false |
| 6 | 5 | Bedtime Stories | $238,652 | -27.6% | 53 | -2 | $4,502 | $674,979 | 2 | Walt Disney Pictures | false | false |
| 7 | 4 | The Day the Earth Stood Still | $183,875 | -48.9% | 80 | - | $2,298 | $1,693,865 | 4 | 20th Century Fox International | false | false |
| 8 | 8 | Burn After Reading | $143,686 | -35% | 35 | - | $4,105 | $1,113,434 | 4 | Universal Pictures International (UPI) | false | false |
| 9 | 7 | Transporter 3 | $136,866 | -42.5% | 28 | - | $4,888 | $1,024,138 | 4 | Belga Films | false | false |
| 10 | 10 | The Flight Before Christmas | $120,201 | -20.9% | 34 | +1 | $3,535 | $442,410 | 3 | Kinepolis Film Distribution (KFD) | false | false |
| 11 | 12 | The Heir Apparent: Largo Winch | $99,355 | -19.6% | 18 | - | $5,519 | $423,211 | 3 | Cinéart | false | false |
| 12 | 11 | Piet Piraat en het zwaard van Zilvertand | $87,371 | -35.3% | 32 | - | $2,730 | $443,261 | 4 | Kinepolis Film Distribution (KFD) | false | false |
| 13 | 13 | Two Lovers | $87,230 | -26.2% | 14 | - | $6,230 | $259,214 | 2 | Cinéart | false | false |
| 14 | 9 | Four Christmases | $79,255 | -59.9% | 25 | - | $3,170 | $324,911 | 2 | Warner Bros. | false | false |
| 15 | 15 | Trouble at Timpetill | $78,443 | -15.6% | 16 | - | $4,902 | $374,172 | 3 | Alternative Films | false | false |
| 16 | 14 | Saw V | $52,330 | -49.6% | 32 | -1 | $1,635 | $542,407 | 3 | Les Films de l'Elysée | false | false |
| 17 | 19 | Blinker en de blixvaten | $42,907 | -33% | 33 | -1 | $1,300 | $210,213 | 3 | Kinepolis Film Distribution (KFD) | false | false |
| 18 | 18 | Quantum of Solace | $42,119 | -39.2% | 15 | -10 | $2,807 | $4,678,525 | 9 | Sony Pictures Releasing | false | false |
| 19 | 16 | Wild Child | $39,211 | -48.9% | 16 | - | $2,450 | $156,147 | 2 | Universal Pictures International (UPI) | false | false |
| 20 | - | Anything for Her | $38,383 | - | 13 | - | $2,952 | $43,375 | 1 | Benelux Film Distributors | true | false |
| 21 | 21 | High School Musical 3: Senior Year | $38,281 | +0.3% | 17 | -2 | $2,251 | $2,500,846 | 10 | Walt Disney Pictures | false | false |
| 22 | 22 | Winter in Wartime | $32,953 | -8.2% | 12 | - | $2,746 | $241,730 | 5 | Benelux Film Distributors | false | false |
| 23 | 17 | Christmas in Paris | $27,971 | -60% | 18 | -2 | $1,553 | $177,228 | 3 | Kinepolis Film Distribution (KFD) | false | false |
| 24 | 20 | Louise hires a contract killer | $26,524 | -39.5% | 11 | -3 | $2,411 | $90,685 | 2 | Les Films de l'Elysée | false | false |
| 25 | 24 | Changeling | $23,375 | -16.2% | 15 | +1 | $1,558 | $884,363 | 8 | Universal Pictures International (UPI) | false | false |
| 26 | 26 | The Visitor | $20,148 | -0.9% | 11 | -1 | $1,831 | $103,037 | 3 | N/A | false | false |
| 27 | 23 | Agathe Cléry | $17,955 | -42.3% | 12 | -1 | $1,496 | $265,677 | 5 | Alternative Films | false | false |
| 28 | 29 | Vicky Cristina Barcelona | $16,910 | +5.5% | 10 | -2 | $1,691 | $1,011,253 | 10 | Cinéart | false | false |
| 29 | 25 | The Silent Army | $16,130 | -35.4% | 9 | - | $1,792 | $108,345 | 3 | N/A | false | false |
| 30 | 27 | Body of Lies | $11,232 | -40.8% | 15 | - | $748 | $798,749 | 7 | Warner Bros. | false | false |
| 31 | 30 | Pride and Glory | $9,662 | -37.7% | 3 | - | $3,220 | $169,601 | 5 | Kinepolis Film Distribution (KFD) | false | false |
| 32 | 35 | Quiet Chaos | $9,148 | -6.8% | 11 | +1 | $831 | $87,986 | 5 | Cinéart | false | false |
| 33 | 33 | Anubis en het Pad der 7 Zonden | $8,410 | -26.4% | 3 | -1 | $2,803 | $1,341,223 | 12 | Kinepolis Film Distribution (KFD) | false | false |
| 34 | 32 | Journey to the Center of the Earth | $8,042 | -35.6% | 4 | - | $2,010 | $291,893 | 8 | Warner Bros. | false | false |
| 35 | 31 | Secret Defense | $7,613 | -39.7% | 5 | -1 | $1,522 | $58,709 | 3 | Les Films de l'Elysée | false | false |
| 36 | 28 | Ghajini | $3,740 | -77.7% | 2 | - | $1,870 | $22,708 | 2 | N/A | false | false |
| 37 | 39 | Elegy | $3,676 | -18.9% | 7 | -42 | $525 | $165,309 | 11 | Kinepolis Film Distribution (KFD) | false | false |
| 38 | 42 | Modern Life | $3,612 | +29.7% | 4 | +1 | $903 | $37,594 | 9 | Benelux Film Distributors | false | false |
| 39 | 41 | Welcome to the Sticks | $2,260 | -25.4% | 4 | -1 | $565 | $10,649,803 | 45 | Alternative Films | false | false |
| 40 | 40 | Public Enemy | $1,581 | -60.2% | 5 | -1 | $316 | $282,554 | 7 | Kinepolis Film Distribution (KFD) | false | false |
| 41 | 46 | A Pain in the Ass | $1,338 | +20.9% | 6 | +1 | $223 | $68,095 | 4 | Benelux Film Distributors | false | false |
| 42 | 45 | Space Chimps | $1,296 | -0.8% | 5 | -2 | $259 | $1,200,452 | 11 | Belga Films | false | false |
| 43 | 36 | The House Bunny | $875 | -88.5% | 1 | -2 | $875 | $36,672 | 3 | Sony Pictures Releasing | false | false |
| 44 | - | The Wave | $842 | - | 1 | - | $842 | $44,656 | 11 | Paradiso Entertainment | false | false |
| 45 | 47 | Home | $827 | -4.8% | 3 | - | $275 | $48,408 | 8 | Benelux Film Distributors | false | false |
| 46 | 48 | The Edge of Love | $807 | -4.7% | 1 | - | $807 | $14,099 | 6 | Belga Films | false | false |
| 47 | 49 | Mamma Mia! | $771 | +22.2% | 5 | - | $154 | $3,479,571 | 17 | Universal Pictures International (UPI) | false | false |
| 48 | 44 | Moscow, Belgium | $768 | -69.4% | 2 | - | $384 | $1,880,590 | 49 | Kinepolis Film Distribution (KFD) | false | false |
| 49 | 43 | Son of Rambow | $752 | -71% | 3 | -2 | $250 | $4,260 | 2 | Universal Pictures International (UPI) | false | false |
| 50 | - | Hunger | $657 | - | 3 | - | $219 | $31,770 | 8 | Paradiso Entertainment | false | false |
| 51 | 50 | Nowhere Man | $416 | +16.9% | 2 | -1 | $208 | $26,213 | 6 | Kinepolis Film Distribution (KFD) | false | false |
| 52 | - | W. | $6 | - | 1 | - | $6 | $125,522 | 10 | Paradiso Entertainment | false | false |
