| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Mr. Bones 2: Back from the Past | $209,118 | -19.6% | 110 | - | $1,901 | $2,276,980 | 4 | United International Pictures | false | false |
| 2 | 2 | Madagascar: Escape 2 Africa | $154,330 | -29.2% | 108 | - | $1,428 | $1,266,741 | 3 | United International Pictures | false | false |
| 3 | - | Twilight | $117,221 | - | 45 | - | $2,604 | $117,221 | 1 | NuMetro Distribution | true | false |
| 4 | 3 | The Day the Earth Stood Still | $85,489 | -37.1% | 80 | -1 | $1,068 | $363,226 | 2 | NuMetro Distribution | false | false |
| 5 | 4 | Quantum of Solace | $74,009 | -22.6% | 81 | -6 | $913 | $1,726,828 | 5 | Ster-Kinekor Pictures | false | false |
| 6 | - | Make It Happen | $68,093 | - | 55 | - | $1,238 | $68,093 | 1 | United International Pictures | true | false |
| 7 | 5 | The Women | $30,270 | -28.6% | 37 | -3 | $818 | $274,276 | 3 | Ster-Kinekor Pictures | false | false |
| 8 | 6 | Rab Ne Bana Di Jodi | $20,116 | -34.6% | 8 | - | $2,514 | $78,383 | 2 | NuMetro Distribution | false | false |
| 9 | 7 | Wild Child | $19,765 | -33.1% | 32 | -12 | $617 | $408,532 | 6 | United International Pictures | false | false |
| 10 | 8 | High School Musical 3: Senior Year | $19,734 | -27.7% | 56 | -13 | $352 | $1,337,392 | 8 | Ster-Kinekor Pictures | false | false |
| 11 | 9 | Body of Lies | $13,023 | -39% | 31 | -8 | $420 | $467,278 | 7 | NuMetro Distribution | false | false |
| 12 | - | Nick and Norah's Infinite Playlist | $8,862 | - | 15 | - | $590 | $8,862 | 1 | Ster-Kinekor Pictures | true | false |
| 13 | - | How to Lose Friends & Alienate People | $8,268 | - | 10 | - | $826 | $8,268 | 1 | United International Pictures | true | false |
| 14 | 12 | Friendship | $4,422 | -33.2% | 5 | - | $884 | $110,905 | 6 | NuMetro Distribution | false | false |
| 15 | 10 | Disaster Movie | $3,303 | -63.6% | 12 | -15 | $275 | $291,028 | 7 | United International Pictures | false | false |
| 16 | 11 | Nights in Rodanthe | $3,192 | -54.3% | 9 | -13 | $354 | $401,464 | 8 | NuMetro Distribution | false | false |
| 17 | 16 | The Boy in the Striped Pajamas | $3,172 | -19.8% | 5 | - | $634 | $21,293 | 3 | Ster-Kinekor Pictures | false | false |
| 18 | 18 | The Counterfeiters | $2,852 | -22.9% | 4 | - | $713 | $56,804 | 7 | Ster-Kinekor Pictures | false | false |
| 19 | 21 | The Band's Visit | $2,734 | -11.1% | 3 | -1 | $911 | $51,158 | 8 | Ster-Kinekor Pictures | false | false |
| 20 | 17 | Religulous | $2,492 | -34.3% | 6 | -2 | $415 | $19,777 | 3 | NuMetro Distribution | false | false |
| 21 | 14 | My Best Friend's Girl | $2,226 | -44.8% | 6 | -2 | $371 | $581,045 | 12 | NuMetro Distribution | false | false |
| 22 | 13 | Death Race | $2,224 | -56.9% | 10 | -6 | $222 | $240,719 | 8 | United International Pictures | false | false |
| 23 | 20 | Mrs. Ratcliffe's Revolution | $2,078 | -38.8% | 5 | - | $415 | $9,679 | 2 | Ster-Kinekor Pictures | false | false |
| 24 | 23 | Fugitive Pieces | $1,089 | -19% | 2 | - | $544 | $17,844 | 8 | United International Pictures | false | false |
| 25 | 22 | Quarantine | $491 | -63.9% | 3 | -3 | $163 | $48,224 | 6 | Ster-Kinekor Pictures | false | false |
| 26 | 24 | Lakeview Terrace | $155 | -74.6% | 1 | -2 | $155 | $129,590 | 9 | Ster-Kinekor Pictures | false | false |
