| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Bolt | $1,509,342 | - | 700 | - | $2,156 | $1,509,342 | 1 | Walt Disney Pictures | true | false |
| 2 | - | Rudo y Cursi | $1,401,738 | - | 505 | - | $2,775 | $1,401,738 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 1 | Madagascar: Escape 2 Africa | $1,344,290 | -55.7% | 445 | -421 | $3,020 | $12,027,767 | 3 | Paramount Pictures International | false | false |
| 4 | 2 | The Day the Earth Stood Still | $1,191,104 | -57.3% | 804 | - | $1,481 | $5,570,288 | 2 | 20th Century Fox International | false | false |
| 5 | - | Four Christmases | $369,968 | - | 287 | - | $1,289 | $369,968 | 1 | Gussi Films | true | false |
| 6 | 3 | Twilight | $299,978 | -45% | 303 | -90 | $990 | $8,718,912 | 5 | Corazón Films | false | false |
| 7 | 5 | Vicky Cristina Barcelona | $45,209 | -64.1% | 52 | -74 | $869 | $580,493 | 3 | Gussi Films | false | false |
| 8 | 4 | Body of Lies | $41,968 | -75.7% | 76 | -165 | $552 | $2,040,346 | 4 | Warner Bros. | false | false |
| 9 | 8 | The Boy in the Striped Pajamas | $39,345 | -17.9% | 33 | -1 | $1,192 | $327,094 | 4 | Walt Disney Pictures | false | false |
| 10 | 12 | Saw V | $33,537 | +8.7% | 59 | -8 | $568 | $904,729 | 8 | Walt Disney Pictures | false | false |
| 11 | 17 | Disaster Movie | $27,599 | +21.1% | 56 | - | $492 | $540,131 | 4 | Gussi Films | false | false |
| 12 | 6 | X-mas, Inc. | $16,696 | -79.6% | 114 | -147 | $146 | $3,570,438 | 6 | Warner Bros. | false | false |
| 13 | 7 | Solstice | $15,331 | -75.1% | 41 | -73 | $373 | $383,236 | 3 | Videocine | false | false |
| 14 | 18 | The Duchess | $14,950 | -25.2% | 19 | +1 | $786 | $269,017 | 5 | Paramount Pictures International | false | false |
| 15 | 39 | Lakeview Terrace | $13,622 | +365.6% | 32 | +18 | $425 | $104,048 | 5 | Sony Pictures Releasing | false | false |
| 16 | 46 | Nick and Norah's Infinite Playlist | $9,991 | +452% | 33 | +12 | $302 | $84,595 | 3 | Sony Pictures Releasing | false | false |
| 17 | 11 | The Women | $8,714 | -78% | 25 | -49 | $348 | $330,248 | 4 | Universal Pictures International (UPI) | false | false |
| 18 | 19 | Death Race | $5,719 | -69.9% | 9 | -34 | $635 | $1,411,118 | 8 | Universal Pictures International (UPI) | false | false |
| 19 | 10 | Mr. Magorium's Wonder Emporium | $5,634 | -86.4% | 27 | -62 | $208 | $1,237,620 | 7 | Zima Entertainment | false | false |
| 20 | 22 | Swing Vote | $3,954 | -69.1% | 15 | -23 | $263 | $277,658 | 7 | Quality Films | false | false |
| 21 | 13 | Quantum of Solace | $3,837 | -87.1% | 20 | -73 | $191 | $5,974,509 | 6 | Sony Pictures Releasing | false | false |
| 22 | 72 | Frozen River | $2,803 | +525.7% | 6 | +5 | $467 | $33,691 | 7 | Sony Pictures Releasing | false | false |
| 23 | 14 | Death Defying Acts | $2,729 | -90.6% | 12 | -46 | $227 | $406,601 | 5 | Gussi Films | false | false |
| 24 | 16 | Pride and Glory | $2,675 | -89.2% | 8 | -51 | $334 | $1,270,210 | 7 | Gussi Films | false | false |
| 25 | 62 | The House Bunny | $2,217 | +187.5% | 7 | - | $316 | $1,329,991 | 9 | Sony Pictures Releasing | false | false |
| 26 | 44 | Pineapple Express | $2,090 | -9.9% | 14 | +1 | $149 | $141,385 | 11 | Sony Pictures Releasing | false | false |
| 27 | 15 | Appaloosa | $1,317 | -95.4% | 8 | -51 | $164 | $52,383 | 2 | Gussi Films | false | false |
| 28 | 24 | Impy's Island | $1,265 | -86.9% | 17 | -26 | $74 | $262,998 | 6 | Gussi Films | false | false |
| 29 | 21 | Be Kind Rewind | $929 | -93% | 7 | -42 | $132 | $303,218 | 8 | Videocine | false | false |
| 30 | 68 | Burn After Reading | $816 | +64.2% | 2 | -1 | $408 | $1,792,279 | 9 | Universal Pictures International (UPI) | false | false |
| 31 | 9 | Mama's Boy | $426 | -99% | 5 | -96 | $85 | $82,701 | 2 | Videocine | false | false |
| 32 | 53 | Satanás | $384 | -62.6% | 3 | -3 | $128 | $119,641 | 8 | Gussi Films | false | false |
| 33 | 29 | Balls of Fury | $255 | -94.5% | 2 | -20 | $127 | $78,411 | 7 | Gussi Films | false | false |
| 34 | 36 | Espérame en otro mundo | $213 | -93.2% | 5 | -23 | $42 | $42,205 | 9 | Videocine | false | false |
| 35 | 98 | Step Brothers | $125 | +38.9% | 1 | -2 | $125 | $638,371 | 13 | Sony Pictures Releasing | false | false |
| 36 | 52 | High School Musical 3: Senior Year | $48 | -95.7% | 2 | -4 | $24 | $4,396,482 | 8 | Walt Disney Pictures | false | false |
