| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Madagascar: Escape 2 Africa | $547,869 | -24.9% | 104 | -51 | $5,267 | $3,559,258 | 3 | Paramount Pictures International | false | false |
| 2 | - | Four Christmases | $110,656 | - | 41 | - | $2,698 | $110,656 | 1 | Distribution Company | true | false |
| 3 | 2 | High School Musical 3: Senior Year | $90,812 | -8.7% | 115 | -9 | $789 | $1,133,761 | 4 | Walt Disney Pictures | false | false |
| 4 | 3 | Body of Lies | $77,909 | -5.6% | 45 | -2 | $1,731 | $669,822 | 4 | Warner Bros. | false | false |
| 5 | 5 | Quarantine | $51,173 | +1.6% | 30 | - | $1,705 | $236,331 | 3 | Sony Pictures Releasing | false | false |
| 6 | 4 | The Duchess | $41,392 | -25.7% | 14 | -1 | $2,956 | $117,882 | 2 | United International Pictures | false | false |
| 7 | - | Fly Me to the Moon 3D | $33,447 | - | 45 | - | $743 | $33,447 | 1 | Distribution Company | true | false |
| 8 | 6 | Righteous Kill | $25,831 | -24.3% | 40 | -4 | $645 | $496,788 | 5 | CDI Films | false | false |
| 9 | 8 | Death Sentence | $23,443 | +0.3% | 33 | -3 | $710 | $126,485 | 3 | Distribution Company | false | false |
| 10 | 12 | Che: Part One | $18,460 | -2.6% | 34 | - | $542 | $611,228 | 6 | Alfa Films | false | false |
| 11 | 7 | Planet Terror | $17,473 | -36.1% | 24 | - | $728 | $55,197 | 2 | Pachamama Cine | false | false |
| 12 | 11 | Quantum of Solace | $17,329 | -10.7% | 14 | -8 | $1,237 | $1,224,103 | 7 | Sony Pictures Releasing | false | false |
| 13 | 9 | RocknRolla | $15,898 | -26.7% | 12 | -1 | $1,324 | $47,245 | 2 | Warner Bros. | false | false |
| 14 | 10 | Deception | $13,547 | -36% | 13 | - | $1,042 | $42,331 | 2 | Alfa Films | false | false |
| 15 | 19 | The Boy in the Striped Pajamas | $9,995 | +13.5% | 13 | +1 | $768 | $61,895 | 3 | Walt Disney Pictures | false | false |
| 16 | 14 | Saw V | $9,589 | -32.3% | 27 | -6 | $355 | $1,033,798 | 8 | Walt Disney Pictures | false | false |
| 17 | 15 | Ira & Abby | $9,501 | -30.8% | 13 | +3 | $730 | $29,129 | 2 | CDI Films | false | false |
| 18 | 21 | Flawless | $9,427 | +18.4% | 22 | -2 | $428 | $237,119 | 7 | Distribution Company | false | false |
| 19 | 18 | My Mom's New Boyfriend | $9,319 | -8.6% | 16 | -4 | $582 | $127,965 | 6 | - | false | false |
| 20 | 16 | Elegy | $8,908 | -28.2% | 20 | - | $445 | $159,626 | 5 | Distribution Company | false | false |
| 21 | 13 | Death Defying Acts | $7,932 | -55.6% | 22 | +4 | $360 | $104,123 | 4 | Alfa Films | false | false |
| 22 | 20 | The Bank Job | $6,705 | -18.7% | 26 | +3 | $257 | $615,473 | 10 | Alfa Films | false | false |
| 23 | 22 | Beverly Hills Chihuahua | $6,239 | -20.8% | 29 | -3 | $215 | $1,549,021 | 11 | Walt Disney Pictures | false | false |
| 24 | 17 | Max Payne | $5,939 | -43.9% | 26 | -5 | $228 | $160,328 | 5 | 20th Century Fox International | false | false |
| 25 | 31 | Tear This Heart Out | $5,876 | +163% | 7 | - | $839 | $34,219 | 4 | 20th Century Fox International | false | false |
| 26 | 25 | La leyenda | $4,316 | -17.9% | 23 | -1 | $187 | $214,359 | 5 | United International Pictures | false | false |
| 27 | 26 | Red Like the Sky 2008 Re-release | $3,360 | -20.4% | 3 | - | $1,120 | $17,490 | 3 | Primer Plano Film Group | false | false |
| 28 | 30 | Fados | $3,173 | +3.3% | 4 | +1 | $793 | $29,234 | 4 | Distribution Company | false | false |
| 29 | 32 | Black Christmas | $2,094 | -1.2% | 9 | +2 | $232 | $94,631 | 6 | Distribution Company | false | false |
| 30 | 28 | Burn After Reading | $1,341 | -60.4% | 8 | -3 | $167 | $863,353 | 9 | United International Pictures | false | false |
| 31 | 33 | Manual of Love 2008 Re-release | $925 | -45.6% | 4 | +1 | $231 | $134,465 | 13 | Notro Films | false | false |
| 32 | 46 | The Magic Flute | $798 | +495.5% | 5 | +4 | $159 | $25,289 | 9 | Distribution Company | false | false |
| 33 | 40 | Blindness | $582 | +27.1% | 4 | - | $145 | $182,163 | 8 | 20th Century Fox International | false | false |
| 34 | 49 | Four Minutes | $337 | +203.6% | 1 | - | $337 | $161,139 | 17 | Alfa Films | false | false |
| 35 | 38 | Shara | $187 | -68.1% | 2 | -1 | $93 | $43,530 | 8 | Zeta Films | false | false |
| 36 | 37 | Nights in Rodanthe | $184 | -72.6% | 6 | - | $30 | $895,812 | 12 | Warner Bros. | false | false |
| 37 | 51 | My Brother is an Only Child | $148 | +57.4% | 1 | - | $148 | $226,436 | 14 | Alfa Films | false | false |
| 38 | 36 | Mirrors | $105 | -88.8% | 1 | -6 | $105 | $622,505 | 12 | 20th Century Fox International | false | false |
| 39 | - | Nos otros | $100 | - | 1 | - | $100 | $2,494 | 4 | CDI Films | false | false |
| 40 | 50 | Hellboy II: The Golden Army | $92 | -14% | 1 | - | $92 | $286,773 | 11 | United International Pictures | false | false |
| 41 | 52 | Mamma Mia! | $89 | +27.1% | 1 | - | $89 | $1,463,082 | 18 | United International Pictures | false | false |
| 42 | 42 | Camera Obscura 2008 Re-release | $70 | -69.7% | 1 | - | $70 | $65,732 | 10 | Distribution Company | false | false |
| 43 | 43 | Days of Darkness | $59 | -72.2% | 1 | -1 | $59 | $15,204 | 10 | Alfa Films | false | false |
| 44 | 54 | Taken | $54 | +42.1% | 1 | - | $54 | $532,281 | 14 | 20th Century Fox International | false | false |
| 45 | - | A Boyfriend for My Wife | $35 | - | 2 | - | $17 | $5,655,290 | 19 | Walt Disney Pictures | false | false |
