| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Four Christmases | $18,180,000 | $16,755,478 | -$1,424,522 | -7.8% | 3,335 | $70,843,000 | $69,418,170 | 2 | Warner Bros. | - |
| 2 | 2 | - | Twilight | $13,197,000 | $13,046,722 | -$150,278 | -1.1% | 3,620 | $138,552,000 | $138,402,068 | 3 | Summit Entertainment | - |
| 3 | 3 | - | Bolt | $9,696,000 | $9,796,149 | +$100,149 | +1% | 3,516 | $79,281,000 | $79,381,422 | 3 | Walt Disney Studios Motion Pictures | - |
| 4 | 4 | - | Australia | $7,000,000 | $7,050,261 | +$50,261 | +0.7% | 2,721 | $30,869,000 | $30,919,097 | 2 | Twentieth Century Fox | - |
| 5 | 5 | - | Quantum of Solace | $6,600,000 | $6,752,390 | +$152,390 | +2.3% | 3,423 | $151,468,000 | $151,620,134 | 4 | Sony Pictures Releasing | - |
| 6 | 6 | - | Madagascar: Escape 2 Africa | $5,100,000 | $5,079,120 | -$20,880 | -0.4% | 3,317 | $165,675,000 | $165,653,852 | 5 | DreamWorks | - |
| 7 | 7 | - | Transporter 3 | $4,500,000 | $4,668,898 | +$168,898 | +3.8% | 2,626 | $25,381,000 | $25,549,454 | 2 | Lionsgate | - |
| 8 | 8 | - | Punisher: War Zone | $4,000,000 | $4,271,451 | +$271,451 | +6.8% | 2,508 | $4,000,000 | $4,271,451 | 1 | Lionsgate | - |
| 9 | 9 | - | Cadillac Records | $3,500,000 | $3,445,559 | -$54,441 | -1.6% | 687 | $3,500,000 | $3,445,559 | 1 | Sony Pictures Releasing | - |
| 10 | 10 | - | Role Models | $2,622,000 | $2,574,460 | -$47,540 | -1.8% | 1,907 | $61,665,000 | $61,617,805 | 5 | Universal Pictures | - |
| 11 | 11 | - | Milk | $1,690,000 | $1,834,914 | +$144,914 | +8.6% | 99 | $4,142,000 | $4,284,465 | 2 | Focus Features | - |
| 12 | 12 | - | Slumdog Millionaire | $1,406,000 | $1,402,176 | -$3,824 | -0.3% | 78 | $5,344,000 | $5,339,510 | 4 | Fox Searchlight Pictures | - |
| 13 | 13 | - | The Boy in the Striped Pajamas | $1,008,000 | $1,031,036 | +$23,036 | +2.3% | 678 | $6,634,000 | $6,657,280 | 5 | Miramax | - |
| 14 | 14 | - | Changeling | $501,000 | $501,070 | +$70 | <0.1% | 681 | $34,683,000 | $34,683,447 | 7 | Universal Pictures | - |
| 15 | 15 | - | Nobel Son | $371,000 | $333,912 | -$37,088 | -10% | 893 | $371,000 | $333,912 | 1 | Freestyle Releasing | - |
| 16 | 16 | - | Rachel Getting Married | $365,000 | $285,331 | -$79,669 | -21.8% | 170 | $9,306,000 | $9,226,246 | 10 | Sony Pictures Classics | - |
| 17 | 17 | - | Fireproof | $225,000 | $251,459 | +$26,459 | +11.8% | 499 | $32,653,000 | $32,678,691 | 11 | The Samuel Goldwyn Company | - |
| 18 | 19 | +1 | Zack and Miri Make a Porno | $212,000 | $226,098 | +$14,098 | +6.6% | 275 | $30,825,000 | $30,839,277 | 6 | The Weinstein Company | - |
| 19 | 20 | +1 | The Secret Life of Bees | $208,000 | $217,469 | +$9,469 | +4.6% | 432 | $36,985,000 | $36,994,417 | 8 | Fox Searchlight Pictures | - |
| 20 | 23 | +3 | Synecdoche, New York | $186,000 | $163,627 | -$22,373 | -12% | 115 | $2,268,000 | $2,244,636 | 7 | Sony Pictures Classics | - |
| 21 | 21 | - | The Dark Knight | $183,000 | $187,418 | +$4,418 | +2.4% | 269 | $530,536,000 | $530,540,885 | 21 | Warner Bros. | - |
| 22 | 22 | - | Frost/Nixon | $180,000 | $180,708 | +$708 | +0.4% | 3 | $180,000 | $180,708 | 1 | Universal Pictures | - |
| 23 | 25 | +2 | I've Loved You So Long | $154,000 | $144,675 | -$9,325 | -6.1% | 51 | $1,760,000 | $1,750,871 | 7 | Sony Pictures Classics | - |
| 24 | 26 | +2 | Happy-Go-Lucky | $149,000 | $141,162 | -$7,838 | -5.3% | 202 | $2,869,000 | $2,861,186 | 9 | Miramax | - |
| 25 | 27 | +2 | Soul Men | $131,000 | $133,421 | +$2,421 | +1.8% | 233 | $11,872,000 | $11,874,010 | 5 | Metro-Goldwyn-Mayer (MGM) | - |
| 26 | 29 | +3 | Eagle Eye | $110,000 | $113,174 | +$3,174 | +2.9% | 205 | $100,402,000 | $100,404,599 | 11 | DreamWorks | - |
| 27 | 32 | +5 | Igor | $56,000 | $65,509 | +$9,509 | +17% | 162 | $19,318,000 | $19,327,987 | 12 | Metro-Goldwyn-Mayer (MGM) | - |
| 28 | 38 | +10 | The Duchess | $44,000 | $44,684 | +$684 | +1.6% | 135 | $13,823,000 | $13,823,741 | 12 | Paramount Vantage | - |
| 29 | 39 | +10 | Saw V | $40,000 | $42,029 | +$2,029 | +5.1% | 115 | $56,728,000 | $56,729,973 | 7 | Lionsgate | - |
| 30 | 43 | +13 | Religulous | $31,000 | $35,630 | +$4,630 | +14.9% | 59 | $12,949,000 | $12,953,375 | 10 | Lionsgate | - |
| 31 | 51 | +20 | Vicky Cristina Barcelona | $27,800 | $23,467 | -$4,333 | -15.6% | 12 | $22,517,000 | $22,512,805 | 17 | Metro-Goldwyn-Mayer (MGM) | - |
| 32 | 60 | +28 | Repo! The Genetic Opera | $15,200 | $13,083 | -$2,117 | -13.9% | 11 | $142,000 | $140,244 | 5 | Lionsgate | - |
| 33 | 75 | +42 | Hounddog | $5,500 | $5,388 | -$112 | -2% | 3 | $128,000 | $128,092 | 12 | Empire Pictures Inc. | - |
| 34 | 77 | +43 | How to Lose Friends & Alienate People | $5,000 | $4,740 | -$260 | -5.2% | 26 | $2,768,000 | $2,775,593 | 10 | Metro-Goldwyn-Mayer (MGM) | - |
| 35 | 115 | +80 | The Other End of the Line | $200 | $215 | +$15 | +7.5% | 1 | $115,000 | $115,504 | 6 | Metro-Goldwyn-Mayer (MGM) | - |
