| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Four Christmases | $31,680,000 | $31,069,826 | -$610,174 | -1.9% | 3,310 | $46,710,000 | $46,054,468 | 1 | Warner Bros. | - |
| 2 | 2 | - | Bolt | $26,596,000 | $26,581,002 | -$14,998 | <0.1% | 3,654 | $66,862,000 | $66,848,840 | 2 | Walt Disney Studios Motion Pictures | - |
| 3 | 3 | - | Twilight | $26,370,000 | $26,344,032 | -$25,968 | <0.1% | 3,425 | $119,688,000 | $119,706,509 | 2 | Summit Entertainment | - |
| 4 | 4 | - | Quantum of Solace | $19,500,000 | $18,833,552 | -$666,448 | -3.4% | 3,501 | $142,056,000 | $141,418,534 | 3 | Sony Pictures Releasing | - |
| 5 | 5 | - | Australia | $14,815,000 | $14,800,723 | -$14,277 | <0.1% | 2,642 | $20,000,000 | $20,004,456 | 1 | Twentieth Century Fox | - |
| 6 | 6 | - | Madagascar: Escape 2 Africa | $14,500,000 | $14,207,329 | -$292,671 | -2% | 3,709 | $159,511,000 | $159,066,369 | 4 | DreamWorks | - |
| 7 | 7 | - | Transporter 3 | $12,330,000 | $12,063,452 | -$266,548 | -2.2% | 2,626 | $18,500,000 | $18,230,758 | 1 | Lionsgate | - |
| 8 | 8 | - | Role Models | $5,284,000 | $5,284,000 | $0 | - | 2,195 | $57,896,000 | $57,780,820 | 4 | Universal Pictures | - |
| 9 | 9 | - | The Boy in the Striped Pajamas | $1,690,000 | $1,696,187 | +$6,187 | +0.4% | 582 | $5,160,000 | $5,169,495 | 4 | Miramax | - |
| 10 | 10 | - | Milk | $1,381,000 | $1,453,844 | +$72,844 | +5.3% | 36 | $1,866,000 | $1,941,472 | 1 | Focus Features | - |
| 11 | 11 | - | Slumdog Millionaire | $1,367,000 | $1,346,039 | -$20,961 | -1.5% | 49 | $3,565,000 | $3,544,374 | 3 | Fox Searchlight Pictures | - |
| 12 | 12 | - | Changeling | $1,207,000 | $1,207,240 | +$240 | <0.1% | 1,010 | $33,859,000 | $33,849,632 | 6 | Universal Pictures | - |
| 13 | 13 | - | High School Musical 3: Senior Year | $1,052,000 | $1,061,628 | +$9,628 | +0.9% | 1,385 | $88,748,000 | $88,751,254 | 6 | Walt Disney Studios Motion Pictures | - |
| 14 | 15 | +1 | Rachel Getting Married | $614,000 | $530,210 | -$83,790 | -13.6% | 216 | $8,881,000 | $8,802,274 | 9 | Sony Pictures Classics | - |
| 15 | 14 | -1 | The Secret Life of Bees | $575,000 | $561,671 | -$13,329 | -2.3% | 490 | $36,667,000 | $36,652,652 | 7 | Fox Searchlight Pictures | - |
| 16 | 16 | - | Zack and Miri Make a Porno | $540,000 | $524,425 | -$15,575 | -2.9% | 437 | $30,445,000 | $30,439,806 | 5 | The Weinstein Company | - |
| 17 | 17 | - | Soul Men | $488,000 | $455,335 | -$32,665 | -6.7% | 335 | $11,685,000 | $11,652,750 | 4 | Metro-Goldwyn-Mayer (MGM) | - |
| 18 | 18 | - | Fireproof | $438,000 | $431,787 | -$6,213 | -1.4% | 486 | $32,313,000 | $32,306,871 | 10 | The Samuel Goldwyn Company | - |
| 19 | 21 | +2 | Synecdoche, New York | $326,000 | $285,822 | -$40,178 | -12.3% | 119 | $2,037,000 | $1,987,861 | 6 | Sony Pictures Classics | - |
| 20 | 20 | - | Happy-Go-Lucky | $320,000 | $289,208 | -$30,792 | -9.6% | 202 | $2,677,000 | $2,641,426 | 8 | Miramax | - |
| 21 | 23 | +2 | Eagle Eye | $260,000 | $247,824 | -$12,176 | -4.7% | 325 | $100,246,000 | $100,232,865 | 10 | DreamWorks | - |
| 22 | 24 | +2 | I've Loved You So Long | $228,000 | $211,806 | -$16,194 | -7.1% | 52 | $1,614,000 | $1,535,070 | 6 | Sony Pictures Classics | - |
| 23 | 30 | +7 | Saw V | $120,000 | $114,179 | -$5,821 | -4.9% | 177 | $56,659,000 | $56,652,813 | 6 | Lionsgate | - |
| 24 | 31 | +7 | Igor | $103,000 | $110,563 | +$7,563 | +7.3% | 179 | $19,236,000 | $19,242,800 | 11 | Metro-Goldwyn-Mayer (MGM) | - |
| 25 | 37 | +12 | The Haunting of Molly Hartley | $74,500 | $69,506 | -$4,994 | -6.7% | 123 | $13,355,000 | $13,350,177 | 5 | Freestyle Releasing | - |
| 26 | 40 | +14 | W. | $59,000 | $56,678 | -$2,322 | -3.9% | 55 | $25,520,000 | $25,517,500 | 7 | Lionsgate | - |
| 27 | 39 | +12 | Religulous | $58,000 | $62,364 | +$4,364 | +7.5% | 61 | $12,885,000 | $12,889,735 | 9 | Lionsgate | - |
| 28 | 44 | +16 | The Duchess | $46,000 | $46,483 | +$483 | +1% | 78 | $13,760,000 | $13,759,842 | 11 | Paramount Vantage | - |
| 29 | 46 | +17 | Vicky Cristina Barcelona | $27,500 | $43,433 | +$15,933 | +57.9% | 18 | $22,462,000 | $22,478,183 | 16 | Metro-Goldwyn-Mayer (MGM) | - |
| 30 | 56 | +26 | Noah's Arc: Jumping the Broom | $21,700 | $20,135 | -$1,565 | -7.2% | 4 | $514,000 | $511,955 | 6 | Logo | - |
| 31 | 66 | +35 | Repo! The Genetic Opera | $5,740 | $10,862 | +$5,122 | +89.2% | 6 | $120,000 | $124,650 | 4 | Lionsgate | - |
| 32 | 71 | +39 | How to Lose Friends & Alienate People | $5,000 | $5,479 | +$479 | +9.6% | 29 | $2,768,000 | $2,768,010 | 9 | Metro-Goldwyn-Mayer (MGM) | - |
| 33 | 103 | +70 | The Other End of the Line | $500 | $577 | +$77 | +15.4% | 2 | $115,000 | $115,024 | 5 | Metro-Goldwyn-Mayer (MGM) | - |
