| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Twilight | $3,026,251 | -39.1% | 545 | -6 | $5,552 | $9,827,154 | 2 | Eagle Pictures | false | false |
| 2 | - | Bolt | $2,176,547 | - | 467 | - | $4,660 | $2,194,621 | 1 | Walt Disney Pictures | true | false |
| 3 | 3 | Body of Lies | $1,246,988 | -23.9% | 318 | -39 | $3,921 | $3,547,751 | 2 | Warner Bros. | false | false |
| 4 | 2 | La fidanzata di papà | $994,808 | -49.3% | 275 | -216 | $3,617 | $7,639,567 | 3 | Medusa Distribuzione | false | false |
| 5 | 4 | Changeling | $909,396 | -21.5% | 267 | -27 | $3,405 | $483,729 | 3 | Universal Pictures International (UPI) | false | false |
| 6 | - | Max Payne | $782,025 | - | 226 | - | $3,460 | $782,025 | 1 | 20th Century Fox International | true | false |
| 7 | - | Just a Father | $742,314 | - | 203 | - | $3,656 | $742,314 | 1 | Warner Bros. | true | false |
| 8 | - | Never Back Down | $734,017 | - | 157 | - | $4,675 | $734,017 | 1 | Medusa Distribuzione | true | false |
| 9 | 5 | Quantum of Solace | $276,587 | -63% | 135 | -161 | $2,048 | $8,784,065 | 4 | Sony Pictures Releasing | false | false |
| 10 | - | Ti stramo: Ho voglia di un'ultima notte da manuale prima di tre baci sopra il cielo | $271,289 | - | 105 | - | $2,583 | $271,289 | 1 | Mikado Film | true | false |
| 11 | - | Death Race | $210,166 | - | 100 | - | $2,101 | $210,166 | 1 | Universal Pictures International (UPI) | true | false |
| 12 | 8 | Galantuomini | $168,801 | -30.7% | 86 | -5 | $1,962 | $505,617 | 2 | 01 Distribution | false | false |
| 13 | 9 | We Can Do That | $156,907 | -30.5% | 59 | -34 | $2,659 | $1,656,520 | 5 | Warner Bros. | false | false |
| 14 | 6 | High School Musical 3: Senior Year | $106,503 | -75.5% | 100 | -166 | $1,065 | $11,559,813 | 5 | Walt Disney Pictures | false | false |
| 15 | 11 | Welcome to the Sticks | $91,997 | -49.8% | 35 | -50 | $2,628 | $3,577,914 | 5 | Medusa Distribuzione | false | false |
| 16 | 7 | The Orphanage | $91,364 | -78.2% | 51 | -134 | $1,791 | $1,757,978 | 3 | Lucky Red | false | false |
| 17 | - | Palermo Shooting | $66,104 | - | 40 | - | $1,652 | $66,104 | 1 | BIM Distribuzione | true | false |
| 18 | 16 | Rachel Getting Married | $64,268 | +2.5% | 20 | +1 | $3,213 | $156,879 | 2 | Sony Pictures Releasing | false | false |
| 19 | 10 | WALL·E | $48,395 | -78.1% | 41 | -89 | $1,180 | $10,932,819 | 7 | Walt Disney Pictures | false | false |
| 20 | 14 | Mamma Mia! | $48,207 | -50.8% | 14 | -27 | $3,443 | $11,110,381 | 9 | United International Pictures | false | false |
| 21 | 15 | Vicky Cristina Barcelona | $36,390 | -53.1% | 17 | -17 | $2,140 | $7,298,304 | 7 | Medusa Distribuzione | false | false |
| 22 | 13 | The Burning Plain | $34,187 | -67.9% | 19 | -53 | $1,799 | $1,602,656 | 4 | Medusa Distribuzione | false | false |
| 23 | 17 | The Class | $29,079 | -39.8% | 16 | -8 | $1,817 | $1,959,268 | 8 | Mikado Film | false | false |
| 24 | 18 | Someone to Run With | $28,117 | -37.2% | 14 | -41 | $2,008 | $100,076 | 2 | Medusa Distribuzione | false | false |
| 25 | 22 | Mid-August Lunch | $14,157 | -24.7% | 8 | - | $1,769 | $2,613,459 | 13 | Fandango | false | false |
| 26 | - | Pineapple Express | $11,136 | - | 11 | - | $1,012 | $11,136 | 1 | Sony Pictures Releasing | true | false |
| 27 | 21 | The Past Is a Foreign Land | $10,153 | -49.9% | 6 | -7 | $1,692 | $894,268 | 5 | 01 Distribution | false | false |
| 28 | - | Se chiudi gli occhi | $7,246 | - | 2 | - | $3,623 | $7,246 | 1 | - | true | false |
| 29 | 20 | The Man Who Loves | $7,058 | -67.8% | 6 | -14 | $1,176 | $1,709,248 | 6 | Medusa Distribuzione | false | false |
| 30 | - | Rumore bianco | $6,623 | - | 3 | - | $2,207 | $7,251 | 1 | N/A | true | false |
| 31 | 25 | The Baader Meinhof Complex | $5,398 | -57.6% | 3 | -8 | $1,799 | $363,153 | 5 | BIM Distribuzione | false | false |
| 32 | 28 | One Day in a Life | $5,030 | -34.8% | 3 | - | $1,676 | $64,158 | 4 | Ripley's Film | false | false |
| 33 | 31 | The Early Bird Catches the Worm | $4,958 | -11.8% | 1 | - | $4,958 | $1,483,103 | 40 | Medusa Distribuzione | false | false |
| 34 | 26 | Burn After Reading | $4,702 | -61.3% | 1 | -3 | $4,702 | $7,689,993 | 11 | Medusa Distribuzione | false | false |
| 35 | 29 | Giovanna's Father | $4,552 | -32.6% | 2 | -2 | $2,276 | $4,790,103 | 12 | Medusa Distribuzione | false | false |
| 36 | - | Márió, a varázsló | $3,289 | - | 1 | - | $3,289 | $3,289 | 1 | L'Altrofilm | true | false |
| 37 | - | Jimmy della collina | $3,197 | - | 3 | - | $1,065 | $71,846 | 35 | Aranciafilm | false | false |
| 38 | 23 | Trick or Treaters | $3,165 | -78.4% | 10 | -21 | $316 | $107,006 | 4 | BIM Distribuzione | false | false |
| 39 | 35 | Lecture 21 | $2,695 | -26.7% | 5 | - | $539 | $338,622 | 7 | 01 Distribution | false | false |
| 40 | 47 | Control | $2,529 | +75.3% | 4 | +2 | $632 | $90,992 | 6 | Metacinema | false | false |
| 41 | - | Horton Hears a Who! | $1,949 | - | 2 | - | $974 | $3,958,990 | 33 | 20th Century Fox International | false | false |
| 42 | 12 | Awake | $1,870 | -98.8% | 2 | -103 | $935 | $873,045 | 3 | Eagle Pictures | false | false |
| 43 | - | The Night of the Sunflowers | $1,684 | - | 1 | - | $1,684 | $67,192 | 25 | Istituto Luce | false | false |
| 44 | - | Birdwatchers | $1,581 | - | 2 | - | $790 | $434,121 | 13 | 01 Distribution | false | false |
| 45 | - | Into the Wild | $1,541 | - | 1 | - | $1,541 | $8,058,998 | 45 | BIM Distribuzione | false | false |
| 46 | - | Il sol dell'avvenire | $1,472 | - | 1 | - | $1,472 | $1,472 | 1 | - | true | false |
| 47 | 24 | Amore che vieni, amore che vai | $1,394 | -89.1% | 4 | -14 | $348 | $110,544 | 3 | Istituto Luce | false | false |
| 48 | 39 | Sopra le nuvole | $1,186 | -54.6% | 1 | - | $1,186 | $13,988 | 2 | N/A | false | false |
| 49 | 30 | Kung Fu Panda | $1,171 | -81.1% | 6 | -4 | $195 | $25,439,889 | 14 | Universal Pictures International (UPI) | false | false |
| 50 | - | Le cose in te nascoste | $1,095 | - | 2 | - | $547 | $1,095 | 1 | - | true | false |
