| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Quantum of Solace | $70,400,000 | $67,528,882 | -$2,871,118 | -4.1% | 3,451 | $70,400,000 | $67,528,882 | 1 | Sony Pictures Releasing | - |
| 2 | 2 | - | Madagascar: Escape 2 Africa | $36,130,000 | $35,017,301 | -$1,112,699 | -3.1% | 4,065 | $118,018,000 | $116,905,195 | 2 | DreamWorks | - |
| 3 | 3 | - | Role Models | $11,710,000 | $11,150,030 | -$559,970 | -4.8% | 2,798 | $38,137,000 | $37,577,245 | 2 | Universal Pictures | - |
| 4 | 4 | - | High School Musical 3: Senior Year | $5,879,000 | $5,656,162 | -$222,838 | -3.8% | 3,202 | $84,392,000 | $84,169,216 | 4 | Walt Disney Studios Motion Pictures | - |
| 5 | 5 | - | Changeling | $4,247,000 | $4,254,080 | +$7,080 | +0.2% | 1,896 | $27,625,000 | $27,631,772 | 4 | Universal Pictures | - |
| 6 | 6 | - | Zack and Miri Make a Porno | $3,200,000 | $3,146,312 | -$53,688 | -1.7% | 2,210 | $26,519,000 | $26,465,482 | 3 | The Weinstein Company | - |
| 7 | 7 | - | Soul Men | $2,428,000 | $2,350,141 | -$77,859 | -3.2% | 2,048 | $9,449,000 | $9,370,925 | 2 | Metro-Goldwyn-Mayer (MGM) | - |
| 8 | 8 | - | The Secret Life of Bees | $2,400,000 | $2,338,279 | -$61,721 | -2.6% | 1,449 | $33,689,000 | $33,627,359 | 5 | Fox Searchlight Pictures | - |
| 9 | 9 | - | Saw V | $1,790,000 | $1,767,405 | -$22,595 | -1.3% | 2,002 | $55,403,000 | $55,380,488 | 4 | Lionsgate | - |
| 10 | 12 | +2 | The Haunting of Molly Hartley | $1,649,000 | $1,438,561 | -$210,439 | -12.8% | 1,587 | $12,695,000 | $12,484,484 | 3 | Freestyle Releasing | - |
| 11 | 10 | -1 | Beverly Hills Chihuahua | $1,538,000 | $1,579,080 | +$41,080 | +2.7% | 1,617 | $90,837,000 | $90,878,127 | 7 | Walt Disney Studios Motion Pictures | - |
| 12 | 11 | -1 | Eagle Eye | $1,538,000 | $1,463,140 | -$74,860 | -4.9% | 1,214 | $98,813,000 | $98,738,396 | 8 | DreamWorks | - |
| 13 | 13 | - | Fireproof | $1,291,000 | $1,255,877 | -$35,123 | -2.7% | 862 | $30,233,000 | $30,198,386 | 8 | The Samuel Goldwyn Company | - |
| 14 | 14 | - | Rachel Getting Married | $1,176,000 | - | - | - | 390 | $7,070,000 | - | 7 | Sony Pictures Classics | - |
| 15 | 15 | - | Body of Lies | $700,000 | $674,495 | -$25,505 | -3.6% | 625 | $38,272,000 | $38,246,741 | 6 | Warner Bros. | - |
| 16 | 17 | +1 | Max Payne | $638,000 | $620,337 | -$17,663 | -2.8% | 845 | $39,981,000 | $39,963,832 | 5 | Twentieth Century Fox | - |
| 17 | 19 | +2 | The Boy in the Striped Pajamas | $490,000 | $474,390 | -$15,610 | -3.2% | 38 | $843,000 | $827,683 | 2 | Miramax | - |
| 18 | 20 | +2 | Appaloosa | $450,000 | $454,518 | +$4,518 | +1% | 737 | $19,409,000 | $19,413,695 | 9 | Warner Bros. | - |
| 19 | 21 | +2 | W. | $450,000 | $444,210 | -$5,790 | -1.3% | 505 | $25,140,000 | $25,134,292 | 5 | Lionsgate | - |
| 20 | 22 | +2 | Pride and Glory | $400,000 | $410,530 | +$10,530 | +2.6% | 575 | $15,361,000 | $15,371,091 | 4 | Warner Bros. | - |
| 21 | 23 | +2 | Happy-Go-Lucky | $374,000 | $370,651 | -$3,349 | -0.9% | 143 | $1,764,000 | $1,760,854 | 6 | Miramax | - |
| 22 | 26 | +4 | Synecdoche, New York | $351,000 | $331,778 | -$19,222 | -5.5% | 80 | $1,143,000 | $1,123,224 | 4 | Sony Pictures Classics | - |
| 23 | 25 | +2 | RocknRolla | $350,000 | $343,980 | -$6,020 | -1.7% | 548 | $5,252,000 | $5,245,837 | 6 | Warner Bros. | - |
| 24 | 24 | - | Slumdog Millionaire | $350,000 | $360,018 | +$10,018 | +2.9% | 10 | $418,000 | $427,715 | 1 | Fox Searchlight Pictures | - |
| 25 | 27 | +2 | The Duchess | $240,000 | $236,779 | -$3,221 | -1.3% | 270 | $13,449,000 | $13,445,348 | 9 | Paramount Vantage | - |
| 26 | 28 | +2 | Religulous | $210,000 | $230,474 | +$20,474 | +9.7% | 238 | $12,530,000 | $12,550,842 | 7 | Lionsgate | - |
| 27 | 32 | +5 | I've Loved You So Long | $176,000 | $163,344 | -$12,656 | -7.2% | 31 | $1,002,000 | $989,361 | 4 | Sony Pictures Classics | - |
| 28 | 37 | +9 | House | $86,400 | $83,771 | -$2,629 | -3% | 234 | $533,000 | $530,184 | 2 | Roadside Attractions | - |
| 29 | 40 | +11 | A Christmas Tale | $65,400 | $63,837 | -$1,563 | -2.4% | 7 | $65,400 | $63,837 | 1 | IFC Films | - |
| 30 | 39 | +9 | JCVD | $63,500 | $68,357 | +$4,857 | +7.6% | 28 | $83,600 | $95,422 | 2 | Peace Arch Entertainment Group | - |
| 31 | 43 | +12 | Vicky Cristina Barcelona | $51,000 | $55,950 | +$4,950 | +9.7% | 39 | $22,341,000 | $22,345,826 | 14 | Metro-Goldwyn-Mayer (MGM) | - |
| 32 | 44 | +12 | Igor | $45,000 | $49,463 | +$4,463 | +9.9% | 78 | $19,044,000 | $19,048,181 | 9 | Metro-Goldwyn-Mayer (MGM) | - |
| 33 | 51 | +18 | Noah's Arc: Jumping the Broom | $32,600 | $32,314 | -$286 | -0.9% | 7 | $451,000 | $451,142 | 4 | Logo | - |
| 34 | 57 | +23 | Repo! The Genetic Opera | $17,800 | $19,029 | +$1,229 | +6.9% | 8 | $89,600 | $90,828 | 2 | Lionsgate | - |
| 35 | 59 | +24 | The Longshots | $17,000 | $16,814 | -$186 | -1.1% | 36 | $11,492,000 | $11,491,806 | 13 | Metro-Goldwyn-Mayer (MGM) | - |
| 36 | 63 | +27 | My Name Is Bruce | $14,900 | $13,336 | -$1,564 | -10.5% | 4 | $73,300 | $71,780 | 3 | Image Entertainment | - |
| 37 | 64 | +27 | Familiar Strangers | $12,300 | $11,553 | -$747 | -6.1% | 2 | $12,300 | $11,553 | 1 | Cavalier Films | - |
| 38 | 75 | +37 | The First Basket | $5,370 | $6,275 | +$905 | +16.9% | 4 | $11,100 | $11,997 | 3 | Laemmle/Zeller Films | - |
| 39 | 83 | +44 | Hounddog | $4,800 | $4,650 | -$150 | -3.1% | 2 | $117,000 | $117,204 | 9 | Empire Pictures Inc. | - |
| 40 | 94 | +54 | Good Dick | $3,900 | $3,020 | -$880 | -22.6% | 2 | $28,400 | $27,595 | 6 | Abramorama | - |
| 41 | 88 | +47 | The Other End of the Line | $3,400 | $3,377 | -$23 | -0.7% | 5 | $111,000 | $110,817 | 3 | Metro-Goldwyn-Mayer (MGM) | - |
| 42 | 91 | +49 | Eden | $2,760 | $3,084 | +$324 | +11.7% | 1 | $2,760 | $3,084 | 1 | Liberation Entertainment | - |
| 43 | 109 | +66 | Gardens of the Night | $1,100 | $780 | -$320 | -29.1% | 1 | $5,150 | $4,831 | 2 | City Lights Pictures | - |
| 44 | 108 | +64 | How to Lose Friends & Alienate People | $750 | $1,086 | +$336 | +44.8% | 5 | $2,759,000 | $2,759,150 | 7 | Metro-Goldwyn-Mayer (MGM) | - |
