| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Madagascar: Escape 2 Africa | $63,500,000 | $63,106,589 | -$393,411 | -0.6% | 4,056 | $63,500,000 | $63,106,589 | 1 | DreamWorks | - |
| 2 | 2 | - | Role Models | $19,251,000 | $19,167,085 | -$83,915 | -0.4% | 2,792 | $19,251,000 | $19,167,085 | 1 | Universal Pictures | - |
| 3 | 3 | - | High School Musical 3: Senior Year | $9,293,000 | $9,159,523 | -$133,477 | -1.4% | 3,464 | $75,707,000 | $75,573,993 | 3 | Walt Disney Studios Motion Pictures | - |
| 4 | 4 | - | Changeling | $7,281,000 | $7,252,940 | -$28,060 | -0.4% | 1,855 | $20,587,000 | $20,559,497 | 3 | Universal Pictures | - |
| 5 | 5 | - | Zack and Miri Make a Porno | $6,521,000 | $6,274,530 | -$246,470 | -3.8% | 2,735 | $20,933,000 | $20,686,907 | 2 | The Weinstein Company | - |
| 6 | 6 | - | Soul Men | $5,610,000 | $5,401,605 | -$208,395 | -3.7% | 2,044 | $5,610,000 | $5,401,605 | 1 | Metro-Goldwyn-Mayer (MGM) | - |
| 7 | 7 | - | Saw V | $4,200,000 | $4,067,071 | -$132,929 | -3.2% | 2,829 | $52,320,000 | $52,187,337 | 3 | Lionsgate | - |
| 8 | 8 | - | The Haunting of Molly Hartley | $3,490,000 | $3,318,694 | -$171,306 | -4.9% | 2,576 | $10,235,000 | $10,063,348 | 2 | Freestyle Releasing | - |
| 9 | 9 | - | The Secret Life of Bees | $3,125,000 | $3,089,467 | -$35,533 | -1.1% | 1,481 | $29,938,000 | $29,902,363 | 4 | Fox Searchlight Pictures | - |
| 10 | 10 | - | Eagle Eye | $2,594,000 | $2,541,602 | -$52,398 | -2% | 1,407 | $96,401,000 | $96,348,829 | 7 | DreamWorks | - |
| 11 | 11 | - | Beverly Hills Chihuahua | $2,485,000 | $2,518,049 | +$33,049 | +1.3% | 2,359 | $88,226,000 | $88,258,841 | 6 | Walt Disney Studios Motion Pictures | - |
| 12 | 12 | - | Max Payne | $1,825,000 | $1,789,136 | -$35,864 | -2% | 1,476 | $38,689,000 | $38,653,498 | 4 | Twentieth Century Fox | - |
| 13 | 15 | +2 | Rachel Getting Married | $1,658,000 | $1,505,507 | -$152,493 | -9.2% | 391 | $5,568,000 | $5,415,820 | 6 | Sony Pictures Classics | - |
| 14 | 13 | -1 | Fireproof | $1,614,000 | $1,585,555 | -$28,445 | -1.8% | 872 | $28,356,000 | $28,327,659 | 7 | The Samuel Goldwyn Company | - |
| 15 | 14 | -1 | Body of Lies | $1,530,000 | $1,537,219 | +$7,219 | +0.5% | 850 | $36,944,000 | $36,950,974 | 5 | Warner Bros. | - |
| 16 | 16 | - | Pride and Glory | $1,240,000 | $1,293,389 | +$53,389 | +4.3% | 1,340 | $14,328,000 | $14,381,710 | 3 | Warner Bros. | - |
| 17 | 17 | - | W. | $1,100,000 | $1,120,600 | +$20,600 | +1.9% | 839 | $24,211,000 | $24,231,628 | 4 | Lionsgate | - |
| 18 | 18 | - | RocknRolla | $1,015,000 | $1,047,334 | +$32,334 | +3.2% | 826 | $4,342,000 | $4,373,979 | 5 | Warner Bros. | - |
| 19 | 19 | - | Appaloosa | $670,000 | $668,415 | -$1,585 | -0.2% | 735 | $18,660,000 | $18,658,697 | 8 | Warner Bros. | - |
| 20 | 22 | +2 | Happy-Go-Lucky | $439,000 | $402,076 | -$36,924 | -8.4% | 102 | $1,282,000 | $1,248,218 | 5 | Miramax | - |
| 21 | 21 | - | The Duchess | $414,000 | $403,984 | -$10,016 | -2.4% | 323 | $13,027,000 | $13,016,496 | 8 | Paramount Vantage | - |
| 22 | 20 | -2 | Religulous | $400,000 | $423,273 | +$23,273 | +5.8% | 274 | $12,103,000 | $12,125,806 | 6 | Lionsgate | - |
| 23 | 23 | - | Burn After Reading | $376,000 | $363,846 | -$12,154 | -3.2% | 270 | $59,514,000 | $59,501,512 | 9 | Focus Features | - |
| 24 | 25 | +1 | House | $355,000 | $327,445 | -$27,555 | -7.8% | 363 | $355,000 | $327,445 | 1 | Roadside Attractions | - |
| 25 | 26 | +1 | Synecdoche, New York | $315,000 | $293,646 | -$21,354 | -6.8% | 35 | $697,000 | $675,537 | 3 | Sony Pictures Classics | - |
| 26 | 27 | +1 | Quarantine | $300,000 | $293,321 | -$6,679 | -2.2% | 353 | $31,458,000 | $31,451,718 | 5 | Screen Gems | - |
| 27 | 28 | +1 | The Boy in the Striped Pajamas | $255,000 | $253,085 | -$1,915 | -0.8% | 17 | $255,000 | $253,085 | 1 | Miramax | - |
| 28 | 32 | +4 | I've Loved You So Long | $188,000 | $186,821 | -$1,179 | -0.6% | 22 | $741,000 | $739,911 | 3 | Sony Pictures Classics | - |
| 29 | 42 | +13 | Sex Drive | $86,000 | $75,920 | -$10,080 | -11.7% | 111 | $8,244,000 | $8,234,346 | 4 | Summit Entertainment | - |
| 30 | 39 | +9 | Vicky Cristina Barcelona | $83,000 | $92,153 | +$9,153 | +11% | 55 | $22,241,000 | $22,249,713 | 13 | Metro-Goldwyn-Mayer (MGM) | - |
| 31 | 44 | +13 | Noah's Arc: Jumping the Broom | $76,700 | $75,034 | -$1,666 | -2.2% | 9 | $391,000 | $389,831 | 3 | Logo | - |
| 32 | 43 | +11 | Igor | $75,000 | $75,434 | +$434 | +0.6% | 116 | $18,969,000 | $18,969,088 | 8 | Metro-Goldwyn-Mayer (MGM) | - |
| 33 | 46 | +13 | Repo! The Genetic Opera | $51,600 | $53,684 | +$2,084 | +4% | 8 | $51,600 | $53,684 | 1 | Lionsgate | - |
| 34 | 62 | +28 | JCVD | $23,300 | $20,119 | -$3,181 | -13.7% | 2 | $23,300 | $20,119 | 1 | Peace Arch Entertainment Group | - |
| 35 | 59 | +24 | The Longshots | $22,000 | $22,351 | +$351 | +1.6% | 38 | $11,467,000 | $11,467,696 | 12 | Metro-Goldwyn-Mayer (MGM) | - |
| 36 | 64 | +28 | The Other End of the Line | $17,000 | $16,512 | -$488 | -2.9% | 51 | $101,000 | $100,759 | 2 | Metro-Goldwyn-Mayer (MGM) | - |
| 37 | 47 | +10 | Fly Me to the Moon 3D | $14,000 | $48,832 | +$34,832 | +248.8% | 29 | $12,173,000 | $12,207,728 | 13 | Summit Entertainment | - |
| 38 | 86 | +48 | Dear Zachary: A Letter to a Son About His Father | $6,900 | $6,619 | -$281 | -4.1% | 3 | $11,300 | $11,051 | 2 | Oscilloscope | - |
| 39 | 90 | +51 | Transsiberian | $6,600 | $5,986 | -$614 | -9.3% | 12 | $2,204,000 | $2,203,641 | 17 | First Look International | - |
| 40 | 99 | +59 | Flow: For Love of Water | $3,750 | $3,746 | -$4 | -0.1% | 6 | $126,000 | $126,202 | 34 | Oscilloscope | - |
| 41 | 102 | +61 | Gardens of the Night | $3,750 | $3,072 | -$678 | -18.1% | 1 | $3,750 | $3,072 | 1 | City Lights Pictures | - |
| 42 | 109 | +67 | The Matador | $2,050 | $1,658 | -$392 | -19.1% | 1 | $11,300 | $10,908 | 2 | City Lights Pictures | - |
| 43 | 113 | +70 | College | $1,000 | $1,035 | +$35 | +3.5% | 6 | $4,694,000 | $4,693,919 | 11 | Metro-Goldwyn-Mayer (MGM) | - |
| 44 | 117 | +73 | How to Lose Friends & Alienate People | $1,000 | $926 | -$74 | -7.4% | 2 | $2,758,000 | $2,757,713 | 6 | Metro-Goldwyn-Mayer (MGM) | - |
