| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Beverly Hills Chihuahua | $20,325,856 | - | 3,218 | - | $6,316 | $55,356,089 | 2 | Walt Disney Studios Motion Pictures | false | false |
| 2 | - | Quarantine | $15,692,897 | - | 2,461 | - | $6,376 | $15,692,897 | 1 | Screen Gems | true | false |
| 3 | - | Body of Lies | $14,518,785 | - | 2,710 | - | $5,357 | $14,518,785 | 1 | Warner Bros. | true | false |
| 4 | - | Eagle Eye | $12,311,253 | - | 3,614 | - | $3,406 | $71,807,470 | 3 | DreamWorks | false | false |
| 5 | - | Nick and Norah's Infinite Playlist | $7,185,038 | - | 2,421 | - | $2,967 | $21,495,272 | 2 | Sony Pictures Releasing | false | false |
| 6 | - | The Express | $5,138,315 | - | 2,808 | - | $1,829 | $5,138,315 | 1 | Universal Pictures | true | false |
| 7 | - | Nights in Rodanthe | $5,113,402 | - | 2,575 | - | $1,985 | $32,869,302 | 3 | Warner Bros. | false | false |
| 8 | - | Appaloosa | $3,775,821 | - | 1,290 | - | $2,926 | $11,322,125 | 4 | Warner Bros. | false | false |
| 9 | - | The Duchess | $3,757,402 | - | 1,207 | - | $3,113 | $6,055,622 | 4 | Paramount Vantage | false | false |
| 10 | - | City of Ember | $3,601,414 | - | 2,022 | - | $1,781 | $3,601,414 | 1 | Twentieth Century Fox | true | false |
| 11 | - | Fireproof | $3,507,852 | - | 875 | - | $4,008 | $17,242,620 | 3 | The Samuel Goldwyn Company | false | false |
| 12 | - | Lakeview Terrace | $2,971,096 | - | 2,218 | - | $1,339 | $36,518,181 | 4 | Screen Gems | false | false |
| 13 | - | Religulous | $2,547,609 | - | 568 | - | $4,485 | $7,049,342 | 2 | Lionsgate Films | false | false |
| 14 | - | Burn After Reading | $2,394,242 | - | 1,406 | - | $1,702 | $55,475,994 | 5 | Focus Features | false | false |
| 15 | - | An American Carol | $1,055,000 | - | 1,621 | - | $650 | $5,631,000 | 2 | Vivendi Entertainment | false | false |
| 16 | - | Flash of Genius | $982,785 | - | 1,098 | - | $895 | $3,859,795 | 2 | Universal Pictures | false | false |
| 17 | - | The Family That Preys | $956,986 | - | 539 | - | $1,775 | $36,522,108 | 5 | Lionsgate Films | false | false |
| 18 | - | Igor | $672,587 | - | 1,195 | - | $562 | $18,186,031 | 4 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 19 | - | The Dark Knight | $620,527 | - | 375 | - | $1,654 | $526,783,113 | 13 | Warner Bros. | false | false |
| 20 | - | Ghost Town | $568,459 | - | 575 | - | $988 | $12,566,278 | 4 | DreamWorks | false | false |
| 21 | - | Miracle at St. Anna | $563,975 | - | 621 | - | $908 | $7,525,754 | 3 | Walt Disney Studios Motion Pictures | false | false |
| 22 | - | Blindness | $562,747 | - | 1,605 | - | $350 | $3,149,413 | 2 | Miramax | false | false |
| 23 | - | My Best Friend's Girl | $562,204 | - | 591 | - | $951 | $18,830,574 | 4 | Lionsgate Films | false | false |
| 24 | - | Righteous Kill | $561,358 | - | 743 | - | $755 | $38,882,770 | 5 | Overture Films | false | false |
| 25 | - | How to Lose Friends & Alienate People | $517,459 | - | 1,673 | - | $309 | $2,535,485 | 2 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 26 | - | Journey to the Center of the Earth | $339,188 | - | 285 | - | $1,190 | $100,500,718 | 14 | Warner Bros. | false | false |
| 27 | - | Vicky Cristina Barcelona | $299,280 | - | 151 | - | $1,981 | $21,492,475 | 9 | - | false | false |
| 28 | - | The Women | $255,800 | - | 345 | - | $741 | $26,514,927 | 5 | Picturehouse | false | false |
| 29 | - | Mamma Mia! | $227,360 | - | 279 | - | $814 | $143,088,835 | 13 | Universal Pictures | false | false |
| 30 | - | RocknRolla | $168,399 | - | 7 | - | $24,057 | $227,284 | 1 | Warner Bros. | true | false |
| 31 | - | Choke | $167,674 | - | 117 | - | $1,433 | $2,724,315 | 3 | - | false | false |
| 32 | - | Tropic Thunder | $167,556 | - | 250 | - | $670 | $109,748,553 | 9 | DreamWorks | false | false |
| 33 | - | The House Bunny | $111,393 | - | 218 | - | $510 | $48,237,389 | 8 | Sony Pictures Releasing | false | false |
| 34 | - | Get Smart | $87,441 | - | 93 | - | $940 | $130,178,805 | 17 | Warner Bros. | false | false |
| 35 | - | Happy-Go-Lucky | $86,573 | - | 4 | - | $21,643 | $86,573 | 1 | Miramax | true | false |
| 36 | - | Death Race | $80,940 | - | 142 | - | $570 | $36,076,270 | 8 | Universal Pictures | false | false |
| 37 | - | Fly Me to the Moon 3D | $74,033 | - | 75 | - | $987 | $12,028,237 | 9 | Summit Entertainment | false | false |
| 38 | - | Deep Sea | $69,770 | - | 10 | - | $6,977 | $36,572,532 | 137 | Warner Bros. | false | false |
| 39 | - | Babylon A.D. | $68,112 | - | 90 | - | $756 | $22,429,826 | 7 | Twentieth Century Fox | false | false |
| 40 | - | Mirrors | $62,732 | - | 109 | - | $575 | $30,516,375 | 9 | Twentieth Century Fox | false | false |
| 41 | - | Traitor | $51,352 | - | 91 | - | $564 | $23,235,798 | 7 | Overture Films | false | false |
| 42 | - | Call + Response | $48,300 | - | 16 | - | $3,018 | $48,300 | 1 | Fair Trade Pictures | true | false |
| 43 | - | Space Chimps | $46,841 | - | 101 | - | $463 | $30,015,521 | 13 | Twentieth Century Fox | false | false |
| 44 | - | Indiana Jones and the Kingdom of the Crystal Skull | $35,791 | - | 60 | - | $596 | $317,015,244 | 21 | Paramount Pictures | false | false |
| 45 | - | Star Wars: The Clone Wars | $32,025 | - | 76 | - | $421 | $34,903,540 | 9 | Warner Bros. | false | false |
| 46 | - | Disaster Movie | $30,337 | - | 61 | - | $497 | $14,113,626 | 7 | Lionsgate Films | false | false |
| 47 | - | The Sisterhood of the Traveling Pants 2 | $20,074 | - | 43 | - | $466 | $43,936,177 | 10 | Warner Bros. | false | false |
| 48 | - | Bangkok Dangerous | $20,043 | - | 56 | - | $357 | $15,235,849 | 6 | Lionsgate Films | false | false |
| 49 | - | The Longshots | $17,133 | - | 42 | - | $407 | $11,325,466 | 8 | - | false | false |
| 50 | - | Hounddog | $15,920 | - | 5 | - | $3,184 | $65,001 | 4 | Empire Pictures Inc. | false | false |
| 51 | - | Lola Montès | $15,109 | - | 3 | - | $5,036 | $15,109 | 1 | Rialto Pictures | true | false |
| 52 | - | Beer for My Horses | $8,748 | - | 27 | - | $324 | $651,520 | 10 | Roadside Attractions | false | false |
| 53 | - | Towelhead | $6,794 | - | 7 | - | $970 | $368,542 | 5 | Warner Independent Pictures (WIP) | false | false |
| 54 | - | Henry Poole Is Here | $6,125 | - | 38 | - | $161 | $1,830,631 | 9 | Overture Films | false | false |
| 55 | - | Lower Learning | $2,581 | - | 1 | - | $2,581 | $2,581 | 1 | Anchor Bay Films | true | false |
| 56 | - | Everybody Wants to Be Italian | $1,158 | - | 1 | - | $1,158 | $351,107 | 6 | Roadside Attractions | false | false |
| 57 | - | I.O.U.S.A. | $901 | - | 1 | - | $901 | $740,654 | 8 | Roadside Attractions | false | false |
| 58 | - | College | $645 | - | 3 | - | $215 | $4,678,827 | 7 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 59 | - | The Fall | $483 | - | 1 | - | $483 | $2,260,353 | 23 | Roadside Attractions | false | false |
| 60 | - | CSNY/Déjà Vu | $236 | - | 1 | - | $236 | $64,160 | 12 | Roadside Attractions | false | false |
