| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Beverly Hills Chihuahua | $17,511,000 | $17,502,077 | -$8,923 | <0.1% | 3,218 | $52,541,000 | $52,532,310 | 2 | Walt Disney Studios Motion Pictures | - |
| 2 | 2 | - | Quarantine | $14,200,000 | $14,211,321 | +$11,321 | <0.1% | 2,461 | $14,200,000 | $14,211,321 | 1 | Screen Gems | - |
| 3 | 3 | - | Body of Lies | $13,120,000 | $12,884,416 | -$235,584 | -1.8% | 2,710 | $13,120,000 | $12,884,416 | 1 | Warner Bros. | - |
| 4 | 4 | - | Eagle Eye | $11,015,000 | $10,913,762 | -$101,238 | -0.9% | 3,614 | $70,551,000 | $70,409,979 | 3 | DreamWorks | - |
| 5 | 5 | - | Nick and Norah's Infinite Playlist | $6,500,000 | $6,420,474 | -$79,526 | -1.2% | 2,421 | $20,810,000 | $20,730,708 | 2 | Sony Pictures Releasing | - |
| 6 | 6 | - | The Express | $4,731,000 | $4,562,675 | -$168,325 | -3.6% | 2,808 | $4,731,000 | $4,562,675 | 1 | Universal Pictures | - |
| 7 | 7 | - | Nights in Rodanthe | $4,610,000 | $4,541,201 | -$68,799 | -1.5% | 2,575 | $32,366,000 | $32,297,101 | 3 | Warner Bros. | - |
| 8 | 8 | - | Appaloosa | $3,340,000 | $3,321,389 | -$18,611 | -0.6% | 1,290 | $10,886,000 | $10,867,693 | 4 | Warner Bros. | - |
| 9 | 9 | - | The Duchess | $3,322,000 | $3,304,841 | -$17,159 | -0.5% | 1,207 | $5,620,000 | $5,603,061 | 4 | Paramount Vantage | - |
| 10 | 11 | +1 | City of Ember | $3,200,000 | $3,129,473 | -$70,527 | -2.2% | 2,022 | $3,200,000 | $3,129,473 | 1 | Twentieth Century Fox | - |
| 11 | 10 | -1 | Fireproof | $3,189,000 | $3,140,997 | -$48,003 | -1.5% | 875 | $16,924,000 | $16,875,765 | 3 | The Samuel Goldwyn Company | - |
| 12 | 12 | - | Lakeview Terrace | $2,650,000 | $2,654,644 | +$4,644 | +0.2% | 2,218 | $36,197,000 | $36,201,729 | 4 | Screen Gems | - |
| 13 | 13 | - | Religulous | $2,200,000 | $2,230,898 | +$30,898 | +1.4% | 568 | $6,702,000 | $6,732,631 | 2 | Lionsgate | - |
| 14 | 14 | - | Burn After Reading | $2,174,000 | $2,095,647 | -$78,353 | -3.6% | 1,406 | $55,255,000 | $55,177,399 | 5 | Focus Features | - |
| 15 | 15 | - | An American Carol | $1,505,000 | $1,055,000 | -$450,000 | -29.9% | 1,621 | $6,081,000 | $5,631,000 | 2 | Vivendi Entertainment | - |
| 16 | 16 | - | Flash of Genius | $862,000 | $867,780 | +$5,780 | +0.7% | 1,098 | $3,739,000 | $3,744,790 | 2 | Universal Pictures | - |
| 17 | 17 | - | The Family That Preys | $730,000 | $840,767 | +$110,767 | +15.2% | 539 | $36,295,000 | $36,405,889 | 5 | Lionsgate | - |
| 18 | 19 | +1 | The Dark Knight | $555,000 | $528,328 | -$26,672 | -4.8% | 375 | $526,718,000 | $526,690,914 | 13 | Warner Bros. | - |
| 19 | 18 | -1 | Igor | $533,000 | $560,410 | +$27,410 | +5.1% | 1,195 | $18,046,000 | $18,073,854 | 4 | Metro-Goldwyn-Mayer (MGM) | - |
| 20 | 20 | - | Ghost Town | $510,000 | $502,402 | -$7,598 | -1.5% | 575 | $12,508,000 | $12,500,221 | 4 | DreamWorks | - |
| 21 | 22 | +1 | Righteous Kill | $479,000 | $483,131 | +$4,131 | +0.9% | 743 | $38,800,000 | $38,804,543 | 5 | Overture Films | - |
| 22 | 21 | -1 | Blindness | $471,000 | $486,726 | +$15,726 | +3.3% | 1,605 | $3,058,000 | $3,073,392 | 2 | Miramax | - |
| 23 | 24 | +1 | Miracle at St. Anna | $466,000 | $480,116 | +$14,116 | +3% | 621 | $7,427,000 | $7,441,895 | 3 | Walt Disney Studios Motion Pictures | - |
| 24 | 25 | +1 | Rachel Getting Married | $464,000 | $445,628 | -$18,372 | -4% | 27 | $882,000 | $863,746 | 2 | Sony Pictures Classics | - |
| 25 | 23 | -2 | My Best Friend's Girl | $450,000 | $480,233 | +$30,233 | +6.7% | 591 | $18,718,000 | $18,748,603 | 4 | Lionsgate | - |
| 26 | 26 | - | How to Lose Friends & Alienate People | $418,000 | $440,066 | +$22,066 | +5.3% | 1,673 | $2,436,000 | $2,458,092 | 2 | Metro-Goldwyn-Mayer (MGM) | - |
| 27 | 29 | +2 | Vicky Cristina Barcelona | $239,000 | $252,468 | +$13,468 | +5.6% | 151 | $21,432,000 | $21,445,663 | 9 | Metro-Goldwyn-Mayer (MGM) | - |
| 28 | 31 | +3 | Billy: The Early Years | $200,000 | $192,042 | -$7,958 | -4% | 282 | $200,000 | $192,042 | 1 | Rocky Mountain Pictures | - |
| 29 | 32 | +3 | Mamma Mia! | $200,000 | $191,090 | -$8,910 | -4.5% | 279 | - | $143,052,565 | 13 | Universal Pictures | - |
| 30 | 33 | +3 | Tropic Thunder | $150,000 | $150,760 | +$760 | +0.5% | 250 | $109,731,000 | $109,731,757 | 9 | DreamWorks | - |
| 31 | 36 | +5 | RocknRolla | $141,000 | $144,701 | +$3,701 | +2.6% | 7 | $200,000 | $203,586 | 1 | Warner Bros. | - |
| 32 | 40 | +8 | Happy-Go-Lucky | $80,000 | $73,867 | -$6,133 | -7.7% | 4 | $80,000 | $73,867 | 1 | Miramax | - |
| 33 | 41 | +8 | Death Race | $70,000 | $69,580 | -$420 | -0.6% | 142 | $36,066,000 | $36,064,910 | 8 | Universal Pictures | - |
| 34 | 52 | +18 | Frozen River | $48,100 | $40,283 | -$7,817 | -16.3% | 51 | $2,069,000 | $2,061,019 | 11 | Sony Pictures Classics | - |
| 35 | 55 | +20 | Transsiberian | $38,900 | $36,350 | -$2,550 | -6.6% | 44 | $2,086,000 | $2,083,095 | 13 | First Look International | - |
| 36 | 50 | +14 | Elegy | $37,900 | $45,176 | +$7,276 | +19.2% | 55 | $3,449,000 | $3,456,676 | 10 | The Samuel Goldwyn Company | - |
| 37 | 64 | +27 | Ashes of Time | $22,000 | $21,372 | -$628 | -2.9% | 5 | $22,000 | $21,372 | 1 | Sony Pictures Classics | - |
| 38 | 60 | +22 | Disaster Movie | $21,000 | $25,995 | +$4,995 | +23.8% | 61 | $14,104,000 | $14,109,284 | 7 | Lionsgate | - |
| 39 | 70 | +31 | Bottle Shock | $20,700 | $17,083 | -$3,617 | -17.5% | 28 | $4,020,000 | $4,016,669 | 10 | Freestyle Releasing | - |
| 40 | 72 | +32 | The Longshots | $15,000 | $16,099 | +$1,099 | +7.3% | 42 | $11,323,000 | $11,324,432 | 8 | Metro-Goldwyn-Mayer (MGM) | - |
| 41 | 69 | +28 | Bangkok Dangerous | $12,000 | $17,176 | +$5,176 | +43.1% | 56 | $15,228,000 | $15,232,982 | 6 | Lionsgate | - |
| 42 | 97 | +55 | Flow: For Love of Water | $4,100 | $3,485 | -$615 | -15% | 6 | $103,000 | $102,178 | 30 | Oscilloscope | - |
| 43 | 127 | +84 | College | $300 | $607 | +$307 | +102.3% | 3 | $4,678,000 | $4,678,789 | 7 | Metro-Goldwyn-Mayer (MGM) | - |
