| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Tropic Thunder | $26,000,000 | $25,812,796 | -$187,204 | -0.7% | 3,319 | $37,033,000 | $36,845,588 | 1 | DreamWorks | - |
| 2 | 2 | - | The Dark Knight | $16,790,000 | $16,379,293 | -$410,707 | -2.4% | 3,590 | $471,493,000 | $471,082,150 | 5 | Warner Bros. | - |
| 3 | 3 | - | Star Wars: The Clone Wars | $15,505,000 | $14,611,273 | -$893,727 | -5.8% | 3,452 | $15,505,000 | $14,611,273 | 1 | Warner Bros. | - |
| 4 | 4 | - | Mirrors | $11,125,000 | $11,161,074 | +$36,074 | +0.3% | 2,664 | $11,125,000 | $11,161,074 | 1 | Twentieth Century Fox | - |
| 5 | 5 | - | Pineapple Express | $10,000,000 | $9,808,295 | -$191,705 | -1.9% | 3,072 | $62,932,000 | $62,740,789 | 2 | Sony Pictures Releasing | - |
| 6 | 6 | - | The Mummy: Tomb of the Dragon Emperor | $8,609,000 | $8,205,720 | -$403,280 | -4.7% | 3,363 | $86,649,000 | $86,245,775 | 3 | Universal Pictures | - |
| 7 | 7 | - | Mamma Mia! | $6,498,000 | $6,096,250 | -$401,750 | -6.2% | 2,771 | - | $116,013,715 | 5 | Universal Pictures | - |
| 8 | 8 | - | The Sisterhood of the Traveling Pants 2 | $5,930,000 | $5,785,250 | -$144,750 | -2.4% | 2,714 | $32,147,000 | $32,002,712 | 2 | Warner Bros. | - |
| 9 | 9 | - | Step Brothers | $5,000,000 | $4,807,904 | -$192,096 | -3.8% | 2,648 | $90,888,000 | $90,695,938 | 4 | Sony Pictures Releasing | - |
| 10 | 10 | - | Vicky Cristina Barcelona | $3,710,000 | $3,755,575 | +$45,575 | +1.2% | 692 | $3,710,000 | $3,755,575 | 1 | Metro-Goldwyn-Mayer (MGM) | - |
| 11 | 11 | - | Journey to the Center of the Earth | $3,455,000 | $3,348,341 | -$106,659 | -3.1% | 1,405 | $88,110,000 | $88,002,999 | 6 | Warner Bros. | - |
| 12 | 12 | - | Fly Me to the Moon 3D | $2,000,000 | $1,900,523 | -$99,477 | -5% | 452 | $2,000,000 | $1,900,523 | 1 | Summit Entertainment | - |
| 13 | 13 | - | WALL·E | $1,840,000 | $1,836,332 | -$3,668 | -0.2% | 1,403 | $214,134,000 | $214,129,943 | 8 | Walt Disney Studios Motion Pictures | - |
| 14 | 14 | - | Hancock | $1,800,000 | $1,720,241 | -$79,759 | -4.4% | 1,277 | $225,102,000 | $225,022,587 | 7 | Sony Pictures Releasing | - |
| 15 | 15 | - | Swing Vote | $1,166,000 | $1,137,385 | -$28,615 | -2.5% | 1,281 | $14,716,000 | $14,687,549 | 3 | Walt Disney Studios Motion Pictures | - |
| 16 | 17 | +1 | Space Chimps | $822,000 | $775,152 | -$46,848 | -5.7% | 768 | $27,607,000 | $27,568,802 | 5 | Twentieth Century Fox | - |
| 17 | 16 | -1 | Henry Poole Is Here | $800,000 | $805,219 | +$5,219 | +0.7% | 527 | $800,000 | $805,219 | 1 | Overture Films | - |
| 18 | 18 | - | Brideshead Revisited | $746,000 | $740,030 | -$5,970 | -0.8% | 501 | $4,656,000 | $4,650,150 | 4 | Miramax | - |
| 19 | 19 | - | Hellboy II: The Golden Army | $564,000 | $541,150 | -$22,850 | -4.1% | 481 | $74,639,000 | $74,616,780 | 6 | Universal Pictures | - |
| 20 | 20 | - | Bottle Shock | $406,000 | $392,440 | -$13,560 | -3.3% | 117 | $850,000 | $837,155 | 2 | Freestyle Releasing | - |
| 21 | 21 | - | Wanted | $376,000 | $368,835 | -$7,165 | -1.9% | 367 | $133,327,000 | $133,319,410 | 8 | Universal Pictures | - |
| 22 | 23 | +1 | Iron Man | $327,000 | $341,178 | +$14,178 | +4.3% | 315 | $317,044,000 | $317,058,295 | 16 | Paramount Pictures | - |
| 23 | 26 | +3 | Tell No One | $320,000 | $275,387 | -$44,613 | -13.9% | 96 | $3,355,000 | $3,310,805 | 7 | Music Box Films | - |
| 24 | 25 | +1 | Kung Fu Panda | $286,000 | $283,677 | -$2,323 | -0.8% | 264 | $211,936,000 | $211,933,936 | 11 | DreamWorks | - |
| 25 | 32 | +7 | Indiana Jones and the Kingdom of the Crystal Skull | $204,000 | $191,324 | -$12,676 | -6.2% | 184 | $315,684,000 | $315,070,993 | 13 | Paramount Pictures | - |
| 26 | 34 | +8 | The Incredible Hulk | $174,000 | $180,120 | +$6,120 | +3.5% | 228 | $134,183,000 | $134,189,490 | 10 | Universal Pictures | - |
| 27 | 40 | +13 | American Teen | $103,000 | $102,542 | -$458 | -0.4% | 105 | $656,000 | $655,937 | 4 | Paramount Vantage | - |
| 28 | 41 | +13 | Transsiberian | $100,000 | $92,483 | -$7,517 | -7.5% | 32 | $337,000 | $329,312 | 5 | First Look International | - |
| 29 | 45 | +16 | Frozen River | $61,300 | $59,664 | -$1,636 | -2.7% | 15 | $256,000 | $254,777 | 3 | Sony Pictures Classics | - |
| 30 | 46 | +16 | Elegy | $54,000 | $54,539 | +$539 | +1% | 6 | $214,000 | $214,891 | 2 | The Samuel Goldwyn Company | - |
| 31 | 48 | +17 | Hell Ride | $48,900 | $44,439 | -$4,461 | -9.1% | 36 | $199,000 | $194,287 | 2 | Third Rail Releasing | - |
| 32 | 49 | +17 | The Wackness | $45,600 | $41,032 | -$4,568 | -10% | 114 | $1,744,000 | $1,739,074 | 7 | Sony Pictures Classics | - |
| 33 | 61 | +28 | A Girl Cut in Two | $19,500 | $18,658 | -$842 | -4.3% | 2 | $19,500 | $18,658 | 1 | IFC Films | - |
| 34 | 69 | +35 | Boy A | $9,670 | $10,728 | +$1,058 | +10.9% | 10 | $83,200 | $84,230 | 4 | The Weinstein Company | - |
| 35 | 79 | +44 | Patti Smith: Dream of Life | $7,000 | $6,703 | -$297 | -4.2% | 1 | $31,200 | $30,918 | 2 | Palm Pictures | - |
