| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | The Dark Knight | $26,030,000 | $26,117,030 | +$87,030 | +0.3% | 4,025 | $441,541,000 | $441,628,497 | 4 | Warner Bros. | - |
| 2 | 2 | - | Pineapple Express | $22,400,000 | $23,245,025 | +$845,025 | +3.8% | 3,072 | $40,474,000 | $41,318,736 | 1 | Sony Pictures Releasing | - |
| 3 | 3 | - | The Mummy: Tomb of the Dragon Emperor | $16,113,000 | $16,490,970 | +$377,970 | +2.3% | 3,778 | $70,671,000 | $71,048,920 | 2 | Universal Pictures | - |
| 4 | 4 | - | The Sisterhood of the Traveling Pants 2 | $10,770,000 | $10,678,430 | -$91,570 | -0.9% | 2,707 | $19,712,000 | $19,620,128 | 1 | Warner Bros. | - |
| 5 | 5 | - | Step Brothers | $8,900,000 | $9,128,662 | +$228,662 | +2.6% | 3,182 | $80,903,000 | $81,132,136 | 3 | Sony Pictures Releasing | - |
| 6 | 6 | - | Mamma Mia! | $8,081,000 | $8,208,580 | +$127,580 | +1.6% | 3,194 | - | $104,144,505 | 4 | Universal Pictures | - |
| 7 | 7 | - | Journey to the Center of the Earth | $4,855,000 | $4,871,478 | +$16,478 | +0.3% | 1,970 | $81,759,000 | $81,775,323 | 5 | Warner Bros. | - |
| 8 | 8 | - | Hancock | $3,300,000 | $3,317,450 | +$17,450 | +0.5% | 2,258 | $221,709,000 | $221,726,791 | 6 | Sony Pictures Releasing | - |
| 9 | 10 | +1 | Swing Vote | $3,106,000 | $3,125,290 | +$19,290 | +0.6% | 2,213 | $12,002,000 | $12,020,828 | 2 | Walt Disney Studios Motion Pictures | - |
| 10 | 9 | -1 | WALL·E | $3,045,000 | $3,140,083 | +$95,083 | +3.1% | 2,144 | $210,112,000 | $210,206,582 | 7 | Walt Disney Studios Motion Pictures | - |
| 11 | 11 | - | Space Chimps | $1,650,000 | $1,767,277 | +$117,277 | +7.1% | 1,631 | $25,447,000 | $25,564,347 | 4 | Twentieth Century Fox | - |
| 12 | 13 | +1 | Hellboy II: The Golden Army | $1,254,000 | $1,254,895 | +$895 | <0.1% | 1,015 | $73,538,000 | $73,539,575 | 5 | Universal Pictures | - |
| 13 | 12 | -1 | The X Files: I Want to Believe | $1,175,000 | $1,290,738 | +$115,738 | +9.9% | 1,695 | $19,635,000 | $19,750,553 | 3 | Twentieth Century Fox | - |
| 14 | 15 | +1 | Brideshead Revisited | $1,059,000 | $1,062,247 | +$3,247 | +0.3% | 349 | $3,344,000 | $3,346,544 | 3 | Miramax | - |
| 15 | 16 | +1 | Wanted | $748,000 | $735,090 | -$12,910 | -1.7% | 642 | $132,616,000 | $132,603,470 | 7 | Universal Pictures | - |
| 16 | 17 | +1 | Get Smart | $490,000 | $496,419 | +$6,419 | +1.3% | 432 | $127,471,000 | $127,477,637 | 8 | Warner Bros. | - |
| 17 | 18 | +1 | Kung Fu Panda | $432,000 | $473,427 | +$41,427 | +9.6% | 408 | $211,315,000 | $211,355,837 | 10 | DreamWorks | - |
| 18 | 19 | +1 | Iron Man | $406,000 | $426,502 | +$20,502 | +5% | 345 | $316,448,000 | $316,468,817 | 15 | Paramount Pictures | - |
| 19 | 20 | +1 | Tell No One | $375,000 | $355,311 | -$19,689 | -5.3% | 102 | $2,878,000 | $2,860,789 | 6 | Music Box Films | - |
| 20 | 22 | +2 | Bottle Shock | $295,000 | $278,075 | -$16,925 | -5.7% | 48 | $365,000 | $347,137 | 1 | Freestyle Releasing | - |
| 21 | 21 | - | The Incredible Hulk | $287,000 | $308,790 | +$21,790 | +7.6% | 332 | $133,823,000 | $133,844,335 | 9 | Universal Pictures | - |
| 22 | 23 | +1 | Man on Wire | $270,000 | $274,040 | +$4,040 | +1.5% | 59 | $432,000 | $435,943 | 3 | Magnolia Pictures | - |
| 23 | 25 | +2 | Indiana Jones and the Kingdom of the Crystal Skull | $231,000 | $234,531 | +$3,531 | +1.5% | 262 | $314,746,000 | $314,749,809 | 12 | Paramount Pictures | - |
| 24 | 26 | +2 | Beer for My Horses | $226,000 | $209,253 | -$16,747 | -7.4% | 91 | $226,000 | $209,253 | 1 | Roadside Attractions | - |
| 25 | 31 | +6 | American Teen | $137,000 | $138,203 | +$1,203 | +0.9% | 76 | $465,000 | $466,362 | 3 | Paramount Vantage | - |
| 26 | 34 | +8 | Elegy | $102,000 | $104,168 | +$2,168 | +2.1% | 6 | $102,000 | $104,168 | 1 | The Samuel Goldwyn Company | - |
| 27 | 36 | +9 | The Wackness | $101,000 | $84,666 | -$16,334 | -16.2% | 97 | $1,656,000 | $1,639,697 | 6 | Sony Pictures Classics | - |
| 28 | 35 | +7 | Hell Ride | $83,500 | $100,164 | +$16,664 | +20% | 82 | $83,500 | $100,164 | 1 | Third Rail Releasing | - |
| 29 | 39 | +10 | Transsiberian | $72,700 | $69,650 | -$3,050 | -4.2% | 14 | $207,000 | $203,938 | 4 | First Look International | - |
| 30 | 41 | +11 | Frozen River | $56,500 | $55,522 | -$978 | -1.7% | 7 | $169,000 | $168,015 | 2 | Sony Pictures Classics | - |
| 31 | 46 | +15 | Encounters at the End of the World | $42,200 | $40,783 | -$1,417 | -3.4% | 36 | $725,000 | $723,966 | 9 | THINKFilm | - |
| 32 | 55 | +23 | Boy A | $27,700 | $25,561 | -$2,139 | -7.7% | 10 | $63,800 | $61,628 | 3 | The Weinstein Company | - |
| 33 | 58 | +25 | Before the Rains | $19,700 | $18,465 | -$1,235 | -6.3% | 27 | $991,000 | $989,486 | 14 | Roadside Attractions | - |
| 34 | 63 | +29 | The Midnight Meat Train | $14,700 | $15,042 | +$342 | +2.3% | 79 | $73,200 | $73,548 | 2 | Lionsgate | - |
| 35 | 71 | +36 | Patti Smith: Dream of Life | $8,080 | $9,993 | +$1,913 | +23.7% | 1 | $14,200 | $15,141 | 1 | Palm Pictures | - |
| 36 | 75 | +39 | The Fall | $6,750 | $7,891 | +$1,141 | +16.9% | 20 | $2,203,000 | $2,203,525 | 14 | Roadside Attractions | - |
