| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Dark Knight | $1,529,617 | -50.8% | 610 | -6 | $2,507 | $8,523,853 | 2 | Warner Bros. | false | false |
| 2 | 2 | Hellboy II: The Golden Army | $307,780 | -38.9% | 257 | -75 | $1,197 | $3,783,229 | 3 | Universal Pictures International (UPI) | false | false |
| 3 | 3 | Get Smart | $181,972 | -30.4% | 160 | -56 | $1,137 | $2,724,405 | 4 | Warner Bros. | false | false |
| 4 | 4 | Wanted | $157,349 | -31.1% | 162 | -35 | $971 | $5,563,269 | 5 | Universal Pictures International (UPI) | false | false |
| 5 | 5 | Un'estate al mare | $116,178 | -38.1% | 144 | -26 | $806 | $7,467,061 | 6 | Medusa Distribuzione | false | false |
| 6 | - | Untraceable | $100,617 | - | 55 | - | $1,829 | $100,617 | 1 | 01 Distribution | true | false |
| 7 | - | Andersen. Zhizn bez lyubvi | $97,266 | - | 17 | - | $5,721 | $97,266 | 1 | Medusa Distribuzione | true | false |
| 8 | 6 | Funny Games | $89,175 | -43.6% | 139 | -44 | $641 | $1,882,939 | 4 | Lucky Red | false | false |
| 9 | - | The Love Guru | $42,595 | - | 48 | - | $887 | $42,595 | 1 | Universal Pictures International (UPI) | true | false |
| 10 | - | Silk | $39,588 | - | 9 | - | $4,398 | $1,569,835 | 41 | Medusa Distribuzione | false | false |
| 11 | 8 | Gracie | $34,301 | -54.4% | 47 | -48 | $729 | $384,165 | 3 | Moviemax | false | false |
| 12 | 11 | Fist of the North Star: The Legends of the True Savior: Legend of Raoh-Chapter of Death in Love 2008 Re-release | $30,986 | -20% | 55 | - | $563 | $847,595 | 5 | Mikado Film | false | false |
| 13 | 7 | The Deaths of Ian Stone | $25,169 | -79.5% | 42 | -50 | $599 | $594,715 | 3 | Medusa Distribuzione | false | false |
| 14 | 12 | Gomorrah | $22,853 | -27.5% | 28 | - | $816 | $15,378,596 | 12 | 01 Distribution | false | false |
| 15 | 14 | Il Divo | $20,723 | -23.2% | 23 | -1 | $901 | $6,863,513 | 10 | Lucky Red | false | false |
| 16 | 16 | Once | $17,658 | +42.1% | 12 | +4 | $1,471 | $667,807 | 10 | Sacher Distribuzione | false | false |
| 17 | 15 | Black House 2008 Re-release | $15,452 | -12.5% | 19 | +1 | $813 | $41,543 | 2 | Ripley's Film | false | false |
| 18 | 13 | The Incredible Hulk | $13,877 | -54.2% | 32 | -26 | $433 | $6,165,769 | 7 | Universal Pictures International (UPI) | false | false |
| 19 | 27 | Indiana Jones and the Kingdom of the Crystal Skull | $11,866 | +152.8% | 9 | - | $1,318 | $17,792,961 | 11 | Universal Pictures International (UPI) | false | false |
| 20 | 19 | The Kite Runner | $8,982 | +0.9% | 8 | +1 | $1,122 | $12,648,488 | 19 | Filmauro | false | false |
| 21 | - | Grace Is Gone | $8,727 | - | 11 | - | $793 | $8,727 | 1 | 01 Distribution | true | false |
| 22 | 42 | No Country for Old Men | $8,294 | +273.8% | 8 | +5 | $1,036 | $8,979,650 | 24 | Universal Pictures International (UPI) | false | false |
| 23 | - | Don't Waste Your Time, Johnny! | $7,188 | - | 3 | - | $2,396 | $654,055 | 36 | Medusa Distribuzione | false | false |
| 24 | 18 | The Year My Parents Went on Vacation | $6,929 | -25.9% | 6 | -1 | $1,154 | $361,221 | 9 | Lucky Red | false | false |
| 25 | 17 | War | $6,137 | -45.2% | 15 | -18 | $409 | $100,103 | 3 | 01 Distribution | false | false |
| 26 | - | Invincible 2008 Re-release | $5,301 | - | 3 | - | $1,767 | $9,673 | 2 | Ripley's Film | false | false |
| 27 | 20 | Caramel | $5,283 | -36.5% | 2 | -6 | $2,641 | $2,258,708 | 33 | Archibald | false | false |
| 28 | 40 | In Bruges | $5,273 | +130.8% | 8 | +4 | $659 | $717,737 | 12 | Mikado Film | false | false |
| 29 | 33 | Impy's Island | $5,272 | +62.5% | 23 | +11 | $229 | $170,252 | 6 | Mediafilm | false | false |
| 30 | 22 | The Rest of the Night 2008 Re-release | $4,923 | -26% | 4 | -3 | $1,230 | $290,951 | 8 | 01 Distribution | false | false |
| 31 | 28 | The Early Bird Catches the Worm | $4,781 | +2.1% | 1 | - | $4,781 | $1,507,509 | 23 | Medusa Distribuzione | false | false |
| 32 | - | The Comebacks | $4,286 | - | 11 | - | $389 | $4,286 | 1 | 20th Century Fox International | true | false |
| 33 | 32 | The Wind Blows Round | $4,227 | +14.9% | 3 | - | $1,409 | $688,209 | 66 | Aranciafilm | false | false |
| 34 | - | The Girl by the Lake | $4,223 | - | 9 | - | $469 | $4,643,501 | 47 | Medusa Distribuzione | false | false |
| 35 | 31 | Things We Lost in the Fire | $3,949 | +4.7% | 7 | +4 | $564 | $412,377 | 8 | Teodora Film | false | false |
| 36 | - | Sex and the City | $3,524 | - | 7 | - | $503 | $10,411,005 | 10 | 01 Distribution | false | false |
| 37 | 44 | Leatherheads | $3,490 | +66.2% | 4 | +2 | $872 | $3,557,685 | 17 | Universal Pictures International (UPI) | false | false |
| 38 | 25 | Tutta la vita davanti | $3,393 | -39.2% | 6 | -3 | $565 | $6,012,007 | 19 | Medusa Distribuzione | false | false |
| 39 | 30 | The Darjeeling Limited | $3,331 | -22% | 4 | - | $832 | $1,107,072 | 14 | 20th Century Fox International | false | false |
| 40 | 46 | Non pensarci | $3,152 | +59.9% | 5 | +1 | $630 | $2,193,605 | 18 | 01 Distribution | false | false |
| 41 | - | Irina Palm | $2,889 | - | 3 | - | $963 | $2,588,050 | 35 | Teodora Film | false | false |
| 42 | 26 | 12 | $2,756 | -48.5% | 6 | -3 | $459 | $116,636 | 6 | 01 Distribution | false | false |
| 43 | 48 | Iron Man | $2,552 | +45.9% | 2 | -3 | $1,276 | $10,809,921 | 14 | Universal Pictures International (UPI) | false | false |
| 44 | 36 | Across the Universe | $2,491 | -11.8% | 2 | - | $1,245 | $1,227,260 | 37 | Sony Pictures Releasing | false | false |
| 45 | 35 | Mongol: The Rise of Genghis Khan | $2,437 | -15.4% | 5 | +1 | $487 | $1,312,287 | 13 | BIM Distribuzione | false | false |
| 46 | - | The Bucket List | $2,286 | - | 2 | - | $1,143 | $2,820,300 | 28 | Warner Bros. | false | false |
| 47 | 43 | Grande, grosso e... Verdone | $2,267 | +4.5% | 3 | - | $755 | $20,124,960 | 22 | Filmauro | false | false |
| 48 | - | American Gangster | $2,203 | - | 4 | - | $550 | $15,520,131 | 29 | Universal Pictures International (UPI) | false | false |
| 49 | 29 | Juno | $2,121 | -53% | 5 | - | $424 | $3,012,357 | 18 | 20th Century Fox International | false | false |
| 50 | - | The Zone | $2,044 | - | 2 | - | $1,022 | $312,516 | 18 | Sacher Distribuzione | false | false |
