| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Wanted | $909,234 | -39.8% | 388 | -5 | $2,343 | $3,956,957 | 2 | Universal Pictures International (UPI) | false | false |
| 2 | - | Get Smart | $833,655 | - | 316 | - | $2,638 | $1,055,760 | 1 | Warner Bros. | true | false |
| 3 | 2 | Un'estate al mare | $782,375 | -42.4% | 418 | -151 | $1,871 | $6,262,848 | 3 | Medusa Distribuzione | false | false |
| 4 | - | Funny Games | $639,990 | - | 204 | - | $3,137 | $639,990 | 1 | Lucky Red | true | false |
| 5 | 4 | The Incredible Hulk | $311,241 | -31.9% | 235 | -106 | $1,324 | $5,875,275 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | 6 | Fist of the North Star: The Legends of the True Savior: Legend of Raoh-Chapter of Death in Love 2008 Re-release | $160,655 | -8.5% | 56 | +22 | $2,868 | $503,957 | 2 | Mikado Film | false | false |
| 7 | 5 | Boogeyman 2 | $100,856 | -49.3% | 152 | -35 | $663 | $429,806 | 2 | Eagle Pictures | false | false |
| 8 | 7 | Street Kings | $74,966 | -54% | 101 | -108 | $742 | $856,206 | 3 | 20th Century Fox International | false | false |
| 9 | 8 | The Happening | $61,016 | -52.8% | 56 | -58 | $1,089 | $3,808,702 | 5 | 20th Century Fox International | false | false |
| 10 | 11 | Gomorrah | $60,801 | -14.2% | 54 | -17 | $1,125 | $15,410,626 | 9 | 01 Distribution | false | false |
| 11 | 10 | Il Divo | $55,008 | -26.2% | 42 | -23 | $1,309 | $6,799,092 | 7 | Lucky Red | false | false |
| 12 | 13 | Go Go Tales | $47,641 | +1% | 28 | +1 | $1,701 | $315,188 | 4 | Mediafilm | false | false |
| 13 | 9 | Made of Honor | $38,953 | -51.7% | 44 | -58 | $885 | $2,702,641 | 5 | Sony Pictures Releasing | false | false |
| 14 | 14 | Impy's Island | $27,598 | -19.1% | 70 | -22 | $394 | $141,536 | 3 | Mediafilm | false | false |
| 15 | 12 | Indiana Jones and the Kingdom of the Crystal Skull | $27,597 | -48.2% | 25 | -33 | $1,103 | $17,997,049 | 8 | Universal Pictures International (UPI) | false | false |
| 16 | 17 | Don't Waste Your Time, Johnny! | $23,769 | -0.1% | 6 | - | $3,961 | $641,607 | 33 | Medusa Distribuzione | false | false |
| 17 | 15 | Once | $22,538 | -23.5% | 22 | -2 | $1,024 | $594,998 | 7 | Sacher Distribuzione | false | false |
| 18 | 3 | Sex and the City | $21,270 | -95.8% | 27 | -34 | $787 | $10,522,405 | 7 | 01 Distribution | false | false |
| 19 | 22 | Il peso dell'aria | $15,117 | +25.2% | 5 | +1 | $3,023 | $40,167 | 2 | - | false | false |
| 20 | 18 | The Year My Parents Went on Vacation | $14,622 | -27.9% | 12 | -4 | $1,218 | $314,765 | 6 | Lucky Red | false | false |
| 21 | - | Prom Night | $13,917 | - | 11 | - | $1,265 | $13,917 | 1 | Sony Pictures Releasing | true | false |
| 22 | 19 | 12 | $12,684 | -37.2% | 12 | -4 | $1,057 | $86,468 | 3 | 01 Distribution | false | false |
| 23 | - | Joshua | $11,419 | - | 9 | - | $1,268 | $11,419 | 1 | 20th Century Fox International | true | false |
| 24 | 20 | The Rest of the Night 2008 Re-release | $11,348 | -39.8% | 14 | -9 | $810 | $264,956 | 5 | 01 Distribution | false | false |
| 25 | 21 | Things We Lost in the Fire | $7,610 | -45.9% | 9 | -12 | $845 | $397,049 | 5 | Teodora Film | false | false |
| 26 | 26 | The Darjeeling Limited | $7,253 | -12.6% | 6 | -2 | $1,208 | $1,093,054 | 11 | 20th Century Fox International | false | false |
| 27 | 29 | Woman's Hearts | $5,523 | -12.1% | 6 | +2 | $920 | $57,314 | 5 | N/A | false | false |
| 28 | 27 | The Kite Runner | $5,298 | -25.5% | 7 | +2 | $756 | $12,779,935 | 16 | Filmauro | false | false |
| 29 | 16 | Man About Town | $5,094 | -80% | 14 | -37 | $363 | $44,230 | 2 | Warner Bros. | false | false |
| 30 | - | The Girl by the Lake | $4,880 | - | 3 | - | $1,626 | $4,739,885 | 44 | Medusa Distribuzione | false | false |
| 31 | 38 | The Night of the Sunflowers | $4,572 | +16.2% | 4 | -2 | $1,143 | $59,585 | 5 | Istituto Luce | false | false |
| 32 | - | Mongol: The Rise of Genghis Khan | $4,297 | - | 7 | - | $613 | $1,316,344 | 10 | BIM Distribuzione | false | false |
| 33 | 42 | No Country for Old Men | $4,168 | +18.4% | 3 | +1 | $1,389 | $9,078,262 | 21 | Universal Pictures International (UPI) | false | false |
| 34 | 40 | Quiet Chaos | $4,089 | +9.4% | 4 | -1 | $1,022 | $8,459,130 | 23 | 01 Distribution | false | false |
| 35 | - | What Happens in Vegas | $4,074 | - | 2 | - | $2,037 | $5,188,588 | 10 | 20th Century Fox International | false | false |
| 36 | 28 | Tutta la vita davanti | $3,865 | -42.5% | 3 | -1 | $1,288 | $6,123,537 | 16 | Medusa Distribuzione | false | false |
| 37 | 23 | Non pensarci | $3,679 | -66.4% | 3 | -3 | $1,226 | $2,228,990 | 15 | 01 Distribution | false | false |
| 38 | 30 | In Bruges | $3,325 | -42.9% | 4 | -2 | $831 | $715,487 | 9 | Mikado Film | false | false |
| 39 | - | Iron Man | $3,242 | - | 6 | - | $540 | $11,051,501 | 11 | Universal Pictures International (UPI) | false | false |
| 40 | - | Alexandra | $3,234 | - | 4 | - | $808 | $64,069 | 7 | N/A | false | false |
| 41 | - | Juno | $3,084 | - | 3 | - | $1,028 | $3,071,983 | 15 | 20th Century Fox International | false | false |
| 42 | - | Amore, bugie & calcetto | $3,032 | - | 4 | - | $758 | $2,230,578 | 15 | Warner Bros. | false | false |
| 43 | 44 | Elite Squad | $2,826 | -6.7% | 4 | -1 | $706 | $224,593 | 6 | Mikado Film | false | false |
| 44 | 33 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $2,810 | -41.9% | 3 | -4 | $936 | $48,507 | 4 | Walt Disney Pictures | false | false |
| 45 | 45 | The Wind Blows Round | $2,731 | -8.8% | 1 | - | $2,731 | $682,876 | 63 | Aranciafilm | false | false |
| 46 | 34 | Lower City 2008 Re-release | $2,678 | -42.8% | 5 | - | $535 | $8,826 | 2 | - | false | false |
| 47 | 25 | Ho ammazzato Berlusconi | $2,637 | -68.7% | 1 | -3 | $2,637 | $61,853 | 4 | Independent Films | false | false |
| 48 | - | Chiamami Salomè | $2,428 | - | 2 | - | $1,214 | $57,999 | 10 | Mediaplex | false | false |
| 49 | - | The Fox and the Child | $2,246 | - | 4 | - | $561 | $2,393,674 | 17 | Lucky Red | false | false |
