| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Un'estate al mare | $2,061,872 | - | 576 | - | $3,579 | $2,061,872 | 1 | Medusa Distribuzione | true | false |
| 2 | 1 | The Incredible Hulk | $894,058 | -41.5% | 469 | -8 | $1,906 | $4,384,578 | 2 | Universal Pictures International (UPI) | false | false |
| 3 | - | Street Kings | $343,037 | - | 247 | - | $1,388 | $343,037 | 1 | 20th Century Fox International | true | false |
| 4 | 2 | The Happening | $282,068 | -23.1% | 194 | -144 | $1,453 | $3,403,126 | 3 | 20th Century Fox International | false | false |
| 5 | 3 | Made of Honor | $205,431 | -35.9% | 213 | -79 | $964 | $2,443,503 | 3 | Sony Pictures Releasing | false | false |
| 6 | 4 | Sex and the City | $128,432 | -42.4% | 139 | -124 | $923 | $10,328,866 | 5 | 01 Distribution | false | false |
| 7 | 6 | Indiana Jones and the Kingdom of the Crystal Skull | $127,443 | -30.3% | 134 | -85 | $951 | $17,859,807 | 6 | Universal Pictures International (UPI) | false | false |
| 8 | 5 | Gomorrah | $122,307 | -35.4% | 150 | -90 | $815 | $15,173,779 | 7 | 01 Distribution | false | false |
| 9 | 7 | Il Divo | $112,931 | -36.3% | 126 | -124 | $896 | $6,551,710 | 5 | Lucky Red | false | false |
| 10 | 8 | Gardener of Eden | $64,093 | -14.6% | 26 | -16 | $2,465 | $225,385 | 2 | Medusa Distribuzione | false | false |
| 11 | 13 | Go Go Tales | $63,873 | +95.3% | 43 | -67 | $1,485 | $127,235 | 2 | Mediafilm | false | false |
| 12 | - | The Ruins | $46,841 | - | 50 | - | $936 | $46,841 | 1 | Universal Pictures International (UPI) | true | false |
| 13 | - | Impy's Island | $46,295 | - | 131 | - | $353 | $46,295 | 1 | Mediafilm | true | false |
| 14 | 12 | Once | $34,640 | +3% | 29 | -2 | $1,194 | $503,895 | 5 | Sacher Distribuzione | false | false |
| 15 | 10 | Unknown | $33,873 | -14% | 22 | -2 | $1,539 | $140,520 | 2 | Eagle Pictures | false | false |
| 16 | - | 12 | $25,833 | - | 15 | - | $1,722 | $25,833 | 1 | 01 Distribution | true | false |
| 17 | 9 | Things We Lost in the Fire | $24,820 | -46.4% | 40 | -49 | $620 | $355,303 | 3 | Teodora Film | false | false |
| 18 | 17 | The Year My Parents Went on Vacation | $22,950 | +22.2% | 20 | +3 | $1,147 | $252,296 | 4 | Lucky Red | false | false |
| 19 | 11 | The Rest of the Night 2008 Re-release | $22,167 | -36.8% | 27 | -22 | $821 | $207,239 | 3 | 01 Distribution | false | false |
| 20 | 27 | Tuttifrutti | $18,752 | +221.2% | 21 | +18 | $892 | $98,926 | 7 | N/A | false | false |
| 21 | 21 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $9,821 | -19.3% | 8 | - | $1,227 | $31,393 | 2 | Walt Disney Pictures | false | false |
| 22 | 29 | Don't Waste Your Time, Johnny! | $9,490 | +82.3% | 2 | +1 | $4,745 | $558,413 | 31 | Medusa Distribuzione | false | false |
| 23 | 20 | Ho ammazzato Berlusconi | $9,234 | -30.7% | 4 | - | $2,308 | $36,946 | 2 | Independent Films | false | false |
| 24 | 24 | The Night of the Sunflowers | $8,508 | -2.2% | 11 | +2 | $773 | $43,272 | 3 | Istituto Luce | false | false |
| 25 | 18 | Savage Grace | $7,854 | -56.7% | 15 | -5 | $523 | $36,890 | 2 | BIM Distribuzione | false | false |
| 26 | 42 | Tutta la vita davanti | $7,411 | +278.1% | 7 | +2 | $1,058 | $5,955,989 | 14 | Medusa Distribuzione | false | false |
| 27 | 30 | Woman's Hearts | $7,398 | +50.9% | 6 | +1 | $1,233 | $37,481 | 3 | N/A | false | false |
| 28 | 25 | Wild Blood | $6,808 | -19.4% | 18 | -3 | $378 | $898,732 | 6 | 01 Distribution | false | false |
| 29 | 28 | In Bruges | $5,921 | +2% | 8 | +3 | $740 | $680,154 | 7 | Mikado Film | false | false |
| 30 | 32 | The Darjeeling Limited | $5,298 | +36.8% | 4 | - | $1,324 | $1,044,914 | 9 | 20th Century Fox International | false | false |
| 31 | 37 | The Wind Blows Round | $5,209 | +88.2% | 3 | +1 | $1,736 | $661,041 | 61 | Aranciafilm | false | false |
| 32 | 19 | Then She Found Me | $5,186 | -61.3% | 9 | -31 | $576 | $917,282 | 4 | Medusa Distribuzione | false | false |
| 33 | 33 | Non pensarci | $5,091 | +37.5% | 3 | - | $1,697 | $2,151,505 | 13 | 01 Distribution | false | false |
| 34 | - | Italian Dream | $4,540 | - | 7 | - | $648 | $4,540 | 1 | Lucky Red | true | false |
| 35 | 14 | Superhero Movie | $4,529 | -81.7% | 13 | -52 | $348 | $4,416,797 | 7 | Medusa Distribuzione | false | false |
| 36 | 26 | Elite Squad | $4,322 | -46.1% | 8 | -7 | $540 | $211,442 | 4 | Mikado Film | false | false |
| 37 | 16 | One Missed Call | $4,293 | -81.8% | 12 | -37 | $357 | $747,957 | 4 | Warner Bros. | false | false |
| 38 | 40 | Mongol: The Rise of Genghis Khan | $4,006 | +83.4% | 6 | +3 | $667 | $1,306,185 | 8 | BIM Distribuzione | false | false |
| 39 | 34 | Iron Man | $3,798 | +8.6% | 4 | -5 | $949 | $10,946,112 | 9 | Universal Pictures International (UPI) | false | false |
| 40 | 22 | Full of It | $2,828 | -73.8% | 9 | -16 | $314 | $89,878 | 3 | Warner Bros. | false | false |
| 41 | 15 | Feel the Noise | $2,743 | -88.4% | 9 | -53 | $304 | $244,011 | 3 | Mediafilm | false | false |
| 42 | 23 | What Happens in Vegas | $2,479 | -75% | 6 | -7 | $413 | $5,134,598 | 8 | 20th Century Fox International | false | false |
| 43 | 35 | Horton Hears a Who! | $2,443 | -27.8% | 10 | -5 | $244 | $3,531,803 | 11 | 20th Century Fox International | false | false |
| 44 | 36 | Alexandra | $1,767 | -45.4% | 4 | -1 | $441 | $52,596 | 5 | N/A | false | false |
| 45 | 46 | The Early Bird Catches the Worm | $1,677 | +72.2% | 2 | +1 | $838 | $1,504,507 | 18 | Medusa Distribuzione | false | false |
| 46 | - | The Secret of the Grain | $1,516 | - | 2 | - | $758 | $2,878,716 | 25 | Lucky Red | false | false |
| 47 | - | Days and Clouds | $1,456 | - | 4 | - | $364 | $6,001,806 | 36 | Warner Bros. | false | false |
| 48 | - | Chiamami Salomè | $1,271 | - | 1 | - | $1,271 | $52,561 | 8 | Mediaplex | false | false |
| 49 | 49 | The Other Boleyn Girl | $1,268 | +70% | 3 | - | $422 | $2,134,271 | 10 | Universal Pictures International (UPI) | false | false |
| 50 | - | The Demons of St. Petersburg | $1,262 | - | 3 | - | $420 | $1,402,002 | 10 | 01 Distribution | false | false |
