| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Incredible Hulk | $3,695,772 | -41.7% | 483 | -1 | $7,651 | $12,458,200 | 2 | Universal Pictures International (UPI) | false | false |
| 2 | 3 | Indiana Jones and the Kingdom of the Crystal Skull | $2,879,712 | -15.9% | 493 | -10 | $5,841 | $74,716,067 | 5 | Paramount Pictures International | false | false |
| 3 | 2 | Sex and the City | $2,391,446 | -31.3% | 465 | -5 | $5,142 | $45,720,765 | 4 | Entertainment Film Distributors | false | false |
| 4 | - | Adulthood | $2,377,161 | - | 157 | - | $15,141 | $2,377,161 | 1 | Pathé | true | false |
| 5 | 4 | The Happening | $1,648,803 | -48.1% | 393 | +3 | $4,195 | $6,421,395 | 2 | 20th Century Fox International | false | false |
| 6 | 5 | Superhero Movie | $992,353 | -1.1% | 362 | -31 | $2,741 | $4,731,183 | 3 | Momentum Pictures | false | false |
| 7 | - | Teeth | $465,543 | - | 188 | - | $2,476 | $465,543 | 1 | Momentum Pictures | true | false |
| 8 | 6 | Gone Baby Gone | $394,394 | -17.8% | 148 | -66 | $2,664 | $2,529,390 | 3 | Walt Disney Pictures | false | false |
| 9 | - | The Edge of Love | $357,244 | - | 52 | - | $6,870 | $357,244 | 1 | Lionsgate Films | true | false |
| 10 | - | The Ruins | $243,989 | - | 168 | - | $1,452 | $243,989 | 1 | Paramount Pictures International | true | false |
| 11 | 7 | Prom Night | $219,192 | -53.8% | 184 | -87 | $1,191 | $2,525,693 | 3 | Sony Pictures Releasing | false | false |
| 12 | 9 | Iron Man | $215,786 | -13.7% | 168 | -76 | $1,284 | $33,859,897 | 8 | Paramount Pictures International | false | false |
| 13 | 14 | Nim's Island | $183,785 | +40.6% | 205 | -63 | $896 | $7,489,143 | 8 | Universal Pictures International (UPI) | false | false |
| 14 | 8 | What Happens in Vegas | $166,464 | -35.6% | 87 | -79 | $1,913 | $15,491,000 | 7 | 20th Century Fox International | false | false |
| 15 | 10 | Mongol: The Rise of Genghis Khan | $163,439 | -34.6% | 70 | -10 | $2,334 | $1,202,519 | 3 | The Works UK Distribution | false | false |
| 16 | 12 | Priceless | $157,855 | -35.4% | 63 | +2 | $2,505 | $560,383 | 2 | Icon Film Distribution | false | false |
| 17 | - | The Escapist | $157,209 | - | 67 | - | $2,346 | $157,209 | 1 | Vertigo Films | true | false |
| 18 | 13 | Mere Baap Pehle Aap | $108,372 | -45.7% | 31 | - | $3,495 | $410,579 | 2 | - | false | false |
| 19 | 11 | Dasavatharam | $88,311 | -64.2% | 19 | - | $4,647 | $426,770 | 2 | Ayngaran International | false | false |
| 20 | 15 | In Search of a Midnight Kiss | $66,166 | -35.7% | 23 | -5 | $2,876 | $251,448 | 2 | Vertigo Films | false | false |
| 21 | - | The Secret of the Grain | $62,849 | - | 11 | - | $5,713 | $62,849 | 1 | Artificial Eye | true | false |
| 22 | 18 | Underdog | $56,772 | +199.7% | 64 | +29 | $887 | $2,950,443 | 21 | Walt Disney Pictures | false | false |
| 23 | 16 | Sarkar Raj | $32,501 | -67.6% | 29 | -19 | $1,120 | $693,584 | 3 | Eros Worldwide | false | false |
| 24 | 17 | Harold & Kumar Escape from Guantanamo Bay | $22,355 | -63.4% | 21 | -43 | $1,064 | $1,359,602 | 4 | Entertainment Film Distributors | false | false |
| 25 | - | De Taali | $21,085 | - | 7 | - | $3,012 | $21,085 | 1 | - | true | false |
| 26 | 20 | Speed Racer | $20,506 | +15.7% | 46 | -29 | $445 | $3,195,774 | 7 | Warner Bros. | false | false |
| 27 | 21 | Caramel | $16,171 | +5.4% | 13 | +1 | $1,243 | $864,787 | 6 | Momentum Pictures | false | false |
| 28 | - | Killer of Sheep 2008 Re-release | $12,001 | - | 2 | - | $6,000 | $12,001 | 1 | British Film Institute (BFI) | true | false |
| 29 | 19 | Persepolis | $11,452 | -37.7% | 9 | -1 | $1,272 | $1,686,784 | 9 | Optimum Releasing | false | false |
| 30 | 24 | Happy-Go-Lucky | $8,038 | -20.5% | 8 | -3 | $1,004 | $3,103,821 | 10 | Momentum Pictures | false | false |
| 31 | 22 | Forgetting Sarah Marshall | $7,355 | -41.8% | 9 | -6 | $817 | $14,994,283 | 9 | Universal Pictures International (UPI) | false | false |
| 32 | 28 | The Game Plan | $5,715 | -8% | 12 | -4 | $476 | $8,395,217 | 16 | Walt Disney Pictures | false | false |
| 33 | - | Honeydripper | $5,059 | - | 4 | - | $1,264 | $156,798 | 7 | Axiom Films | false | false |
| 34 | 27 | Made of Honor | $4,918 | -22.9% | 2 | -1 | $2,459 | $4,699,956 | 8 | Sony Pictures Releasing | false | false |
| 35 | 26 | Let's Get Lost | $4,526 | -49.9% | 7 | -1 | $646 | $73,149 | 3 | - | false | false |
| 36 | 23 | Jules and Jim 2008 Re-release | $4,190 | -64.6% | 2 | -4 | $2,095 | $148,151 | 4 | British Film Institute (BFI) | false | false |
| 37 | 33 | U2 3D | $3,913 | +50.3% | 3 | +1 | $1,304 | $1,432,256 | 18 | Revolver Entertainment | false | false |
| 38 | 30 | California Dreamin' | $3,487 | -13.1% | 5 | +4 | $697 | $55,506 | 4 | Artificial Eye | false | false |
| 39 | 25 | The Passionate Friends | $3,435 | -64.8% | 1 | -12 | $3,435 | $27,540 | 3 | British Film Institute (BFI) | false | false |
| 40 | 29 | Heartbeat Detector | $3,343 | -45% | 4 | -1 | $835 | $145,529 | 6 | Trinity Filmed Entertainment | false | false |
| 41 | 62 | The Orphanage | $3,028 | +7,664.1% | 2 | +1 | $1,514 | $3,469,953 | 14 | Optimum Releasing | false | false |
| 42 | - | Her Name Is Sabine | $2,343 | - | 1 | - | $2,343 | $2,343 | 1 | ICA Films | true | false |
| 43 | 39 | Welcome to the Sticks | $2,179 | +19.3% | 3 | +1 | $726 | $212,888 | 12 | Pathé | false | false |
| 44 | 32 | Smart People | $2,098 | -44.2% | 4 | -3 | $524 | $400,097 | 6 | Icon Film Distribution | false | false |
| 45 | 40 | Lars and the Real Girl | $2,041 | +17.2% | 2 | - | $1,020 | $875,399 | 14 | Verve Pictures | false | false |
| 46 | 52 | Private Property | $1,831 | +167.3% | 3 | +1 | $610 | $59,925 | 10 | Soda Pictures | false | false |
| 47 | 31 | The Diving Bell and the Butterfly | $1,689 | -57.5% | 2 | -1 | $844 | $1,777,566 | 20 | Pathé | false | false |
| 48 | 41 | Shotgun Stories | $1,571 | -8.8% | 5 | +1 | $314 | $33,742 | 5 | Vertigo Films | false | false |
| 49 | 56 | The Last Mistress | $1,529 | +272% | 2 | +1 | $764 | $81,968 | 11 | Artificial Eye | false | false |
| 50 | 58 | The Bank Job | $1,492 | +638.6% | 1 | - | $1,492 | $8,068,923 | 17 | Lionsgate Films | false | false |
| 51 | 44 | Cassandra's Dream | $1,450 | +19.1% | 1 | -1 | $1,450 | $221,015 | 5 | Optimum Releasing | false | false |
| 52 | 37 | Taxi to the Dark Side | $796 | -63.1% | 1 | - | $796 | $6,958 | 2 | Revolver Entertainment | false | false |
| 53 | 36 | XXY | $437 | -81.3% | 1 | -1 | $437 | $117,446 | 7 | Peccadillo Pictures | false | false |
| 54 | 47 | Son of Rambow | $375 | -62.3% | 2 | -1 | $187 | $8,250,735 | 12 | Optimum Releasing | false | false |
| 55 | 54 | Manufactured Landscapes | $316 | -46.4% | 2 | +1 | $158 | $41,509 | 7 | British Film Institute (BFI) | false | false |
| 56 | 48 | Where in the World Is Osama Bin Laden? | $298 | -67.8% | 2 | -1 | $149 | $140,573 | 7 | Optimum Releasing | false | false |
| 57 | 42 | You, the Living | $269 | -84.2% | 1 | -2 | $269 | $198,467 | 13 | Artificial Eye | false | false |
| 58 | 45 | Irina Palm | $148 | -86.9% | 1 | -1 | $148 | $2,066 | 2 | Soda Pictures | false | false |
| 59 | 61 | The Air I Breathe | $130 | +233.3% | 1 | - | $130 | $7,058 | 6 | Pathé | false | false |
| 60 | 38 | My Brother is an Only Child | $40 | -98.1% | 1 | -3 | $40 | $648,813 | 12 | Revolver Entertainment | false | false |
| 61 | 50 | Charlie Bartlett | $40 | -95.5% | 1 | -1 | $40 | $388,748 | 6 | Verve Pictures | false | false |
