| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Indiana Jones and the Kingdom of the Crystal Skull | $28,325 | -43.7% | 9 | - | $3,147 | $138,253 | 2 | - | false | false |
| 2 | 2 | What Happens in Vegas | $6,873 | +2.1% | 5 | - | $1,374 | $55,757 | 4 | Tuck | false | false |
| 3 | 3 | 21 | $1,754 | +32.8% | 5 | - | $350 | $33,853 | 6 | Tuck | false | false |
| 4 | 4 | Iron Man | $1,519 | +20.4% | 4 | - | $379 | $33,522 | 5 | - | false | false |
| 5 | 13 | Horton Hears a Who! | $906 | +198% | 6 | - | $151 | $67,817 | 12 | Tuck | false | false |
| 6 | 8 | Obituary for Escobar | $630 | +51.8% | 17 | - | $37 | $534,929 | 13 | Cinears | false | false |
| 7 | 5 | Speed Racer | $516 | +1.8% | 4 | - | $129 | $5,090 | 4 | Tuck | false | false |
| 8 | 7 | Fool's Gold | $484 | -3% | 5 | - | $96 | $57,620 | 9 | Tuck | false | false |
| 9 | 10 | Vantage Point | $474 | +21.5% | 4 | - | $118 | $15,742 | 7 | Tuck | false | false |
| 10 | 11 | Step Up 2: The Streets | $387 | +6% | 3 | - | $129 | $14,895 | 7 | Mirius | false | false |
| 11 | 17 | The Bucket List | $362 | +93.6% | 2 | - | $181 | $43,991 | 10 | Tuck | false | false |
| 12 | 14 | Tears for Sale | $285 | -3.4% | 20 | - | $14 | $594,964 | 19 | Mirius | false | false |
| 13 | 21 | Street Kings | $267 | +145% | 3 | - | $89 | $15,660 | 8 | Tuck | false | false |
| 14 | 16 | The Spiderwick Chronicles | $257 | +20.1% | 6 | - | $42 | $20,813 | 8 | - | false | false |
| 15 | 20 | The Water Horse | $189 | +65.8% | 4 | - | $47 | $13,590 | 11 | Tuck | false | false |
| 16 | 18 | Love in the Time of Cholera | $185 | +7.6% | 3 | - | $61 | $40,496 | 14 | Mirius | false | false |
| 17 | 9 | Paper Prince | $169 | -58.3% | 4 | - | $42 | $12,346 | 9 | Art Vista | false | false |
| 18 | 27 | 27 Dresses | $150 | +138.1% | 5 | - | $30 | $42,338 | 16 | Tuck | false | false |
| 19 | - | P.S. I Love You | $148 | - | 2 | - | $74 | $30,377 | 25 | Mirius | false | false |
| 20 | 33 | Shadows | $77 | +120% | 2 | - | $38 | $7,104 | 8 | Mirius | false | false |
| 21 | - | Sweeney Todd: The Demon Barber of Fleet Street | $75 | - | 2 | - | $37 | $41,171 | 14 | Tuck | false | false |
| 22 | 30 | Lust, Caution | $75 | +63% | 1 | - | $75 | $23,084 | 14 | N/A | false | false |
| 23 | 36 | Cloverfield | $62 | +169.6% | 1 | -1 | $62 | $21,904 | 17 | - | false | false |
| 24 | - | Alvin and the Chipmunks | $61 | - | 4 | - | $15 | $50,786 | 22 | Tuck | false | false |
| 25 | 28 | No Country for Old Men | $49 | -5.8% | 2 | - | $24 | $44,453 | 14 | - | false | false |
| 26 | 24 | Sukiyaki Western Django | $46 | -38.7% | 1 | - | $46 | $6,709 | 10 | N/A | false | false |
| 27 | 23 | Aliens vs. Predator: Requiem | $35 | -60.7% | 4 | - | $8 | $48,224 | 24 | Tuck | false | false |
| 28 | - | Hitman | $26 | - | 3 | - | $8 | $31,180 | 27 | Tuck | false | false |
| 29 | 32 | Jumper | $16 | -57.9% | 5 | - | $3 | $69,373 | 17 | Tuck | false | false |
| 30 | 38 | Eastern Promises | $15 | +25% | 1 | - | $15 | $13,626 | 12 | N/A | false | false |
| 31 | 37 | The Darjeeling Limited | $11 | -35.3% | 1 | - | $11 | $19,009 | 11 | Tuck | false | false |
| 32 | 40 | Goodbye Bafana | $9 | +50% | 2 | - | $4 | $611 | 5 | N/A | false | false |
