| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Sex and the City | $55,740,000 | $57,038,404 | +$1,298,404 | +2.3% | 3,285 | $55,740,000 | $57,038,404 | 1 | Warner Bros. | - |
| 2 | 2 | - | Indiana Jones and the Kingdom of the Crystal Skull | $46,000,000 | $44,754,615 | -$1,245,385 | -2.7% | 4,264 | $216,881,000 | $215,635,899 | 2 | Paramount Pictures | - |
| 3 | 3 | - | The Strangers | $20,707,000 | $20,997,985 | +$290,985 | +1.4% | 2,466 | $20,707,000 | $20,997,985 | 1 | Rogue Pictures | - |
| 4 | 4 | - | Iron Man | $14,000,000 | $13,541,264 | -$458,736 | -3.3% | 3,650 | $276,625,000 | $276,166,336 | 5 | Paramount Pictures | - |
| 5 | 5 | - | The Chronicles of Narnia: Prince Caspian | $13,016,000 | $12,704,545 | -$311,455 | -2.4% | 3,801 | $115,674,000 | $115,362,725 | 3 | Walt Disney Studios Motion Pictures | - |
| 6 | 6 | - | What Happens in Vegas | $6,850,000 | $6,681,097 | -$168,903 | -2.5% | 3,086 | $66,074,000 | $65,904,971 | 4 | Twentieth Century Fox | - |
| 7 | 8 | +1 | Baby Mama | $2,221,000 | $2,194,320 | -$26,680 | -1.2% | 1,784 | $56,145,000 | $56,117,805 | 6 | Universal Pictures | - |
| 8 | 7 | -1 | Speed Racer | $2,140,000 | $2,259,031 | +$119,031 | +5.6% | 2,070 | $40,558,000 | $40,677,371 | 4 | Warner Bros. | - |
| 9 | 9 | - | Made of Honor | $2,000,000 | $1,913,035 | -$86,965 | -4.3% | 1,905 | $42,965,000 | $42,878,354 | 5 | Sony Pictures Releasing | - |
| 10 | 10 | - | Forgetting Sarah Marshall | $1,044,000 | $1,059,840 | +$15,840 | +1.5% | 768 | $60,471,000 | $60,485,980 | 7 | Universal Pictures | - |
| 11 | 11 | - | The Visitor | $603,000 | $553,704 | -$49,296 | -8.2% | 270 | $5,372,000 | $5,322,550 | 8 | Overture Films | - |
| 12 | 12 | - | Harold & Kumar Escape from Guantanamo Bay | $475,000 | $487,021 | +$12,021 | +2.5% | 474 | $36,955,000 | $36,967,086 | 6 | Warner Bros. | - |
| 13 | 13 | - | Horton Hears a Who! | $385,000 | $367,734 | -$17,266 | -4.5% | 428 | $152,589,000 | $152,571,420 | 12 | Twentieth Century Fox | - |
| 14 | 14 | - | The Fall | $361,000 | $345,466 | -$15,534 | -4.3% | 109 | $662,000 | $646,692 | 4 | Roadside Attractions | - |
| 15 | 16 | +1 | Then She Found Me | $272,000 | $244,812 | -$27,188 | -10% | 150 | $2,546,000 | $2,519,002 | 6 | THINKFilm | - |
| 16 | 15 | -1 | The Forbidden Kingdom | $247,000 | $247,656 | +$656 | +0.3% | 262 | $51,730,000 | $51,730,925 | 7 | Lionsgate | - |
| 17 | 17 | - | Nim's Island | $242,000 | $230,671 | -$11,329 | -4.7% | 350 | $46,120,000 | $46,109,150 | 9 | Twentieth Century Fox | - |
| 18 | 18 | - | Young@Heart | $222,000 | $220,190 | -$1,810 | -0.8% | 197 | $2,842,000 | $2,840,511 | 8 | Fox Searchlight Pictures | - |
| 19 | 21 | +2 | Son of Rambow | $171,000 | $165,570 | -$5,430 | -3.2% | 139 | $1,181,000 | $1,175,679 | 5 | Paramount Vantage | - |
| 20 | 24 | +4 | Roman de gare | $105,000 | $104,267 | -$733 | -0.7% | 35 | $849,000 | $848,202 | 6 | The Samuel Goldwyn Company | - |
| 21 | 27 | +6 | The Counterfeiters | $90,500 | $80,161 | -$10,339 | -11.4% | 97 | $5,165,000 | $5,154,980 | 15 | Sony Pictures Classics | - |
| 22 | 26 | +4 | Superhero Movie | $78,000 | $82,780 | +$4,780 | +6.1% | 157 | $25,634,000 | $25,638,520 | 10 | Metro-Goldwyn-Mayer (MGM) | - |
| 23 | 31 | +8 | Before the Rains | $68,800 | $64,932 | -$3,868 | -5.6% | 44 | $449,000 | $445,280 | 4 | Roadside Attractions | - |
| 24 | 33 | +9 | Leatherheads | $58,000 | $60,015 | +$2,015 | +3.5% | 138 | $31,197,000 | $31,199,215 | 9 | Universal Pictures | - |
| 25 | 35 | +10 | Reprise | $57,000 | $50,720 | -$6,280 | -11% | 14 | $260,000 | $253,785 | 3 | Miramax | - |
| 26 | 36 | +10 | The Children of Huang Shi | $50,500 | $45,392 | -$5,108 | -10.1% | 17 | $116,000 | $111,137 | 2 | Sony Pictures Classics | - |
| 27 | 34 | +7 | The Bank Job | $48,000 | $52,959 | +$4,959 | +10.3% | 130 | $30,024,000 | $30,028,592 | 13 | Lionsgate | - |
| 28 | 37 | +9 | Priceless | $42,800 | $45,116 | +$2,316 | +5.4% | 35 | $1,636,000 | $1,638,226 | 10 | The Samuel Goldwyn Company | - |
| 29 | 41 | +12 | The Foot Fist Way | $36,000 | $36,391 | +$391 | +1.1% | 4 | $36,000 | $36,391 | 1 | Paramount Vantage | - |
| 30 | 47 | +17 | Fugitive Pieces | $28,900 | $31,386 | +$2,486 | +8.6% | 26 | $446,000 | $449,048 | 5 | The Samuel Goldwyn Company | - |
| 31 | 56 | +25 | My Blueberry Nights | $27,200 | $23,248 | -$3,952 | -14.5% | 46 | $771,000 | $766,989 | 9 | The Weinstein Company | - |
| 32 | 58 | +26 | War, Inc. | $24,200 | $19,970 | -$4,230 | -17.5% | 2 | $78,700 | $74,474 | 2 | First Look International | - |
| 33 | 59 | +26 | Under the Same Moon | $17,200 | $18,618 | +$1,418 | +8.2% | 41 | $12,460,000 | $12,461,368 | 11 | The Weinstein Company | - |
| 34 | 68 | +34 | The Year My Parents Went on Vacation | $11,300 | $10,672 | -$628 | -5.6% | 5 | $747,000 | $746,551 | 16 | City Lights Pictures | - |
| 35 | 72 | +37 | Stuck | $10,200 | $8,844 | -$1,356 | -13.3% | 2 | $10,200 | $8,844 | 1 | THINKFilm | - |
| 36 | 80 | +44 | The Unknown Woman | $6,000 | $5,701 | -$299 | -5% | 1 | $91,900 | $91,614 | 1 | Outsider Pictures | - |
| 37 | 84 | +47 | Trying to Get Good: The Jazz Odyssey of Jack Sheldon | $4,950 | $4,792 | -$158 | -3.2% | 1 | $4,950 | $4,792 | 1 | Reel Source | - |
