| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Indiana Jones and the Kingdom of the Crystal Skull | $101,000,000 | $100,137,835 | -$862,165 | -0.9% | 4,260 | $126,000,000 | $125,178,907 | 1 | Paramount Pictures | - |
| 2 | 2 | - | The Chronicles of Narnia: Prince Caspian | $23,032,000 | $22,794,989 | -$237,011 | -1% | 3,929 | $91,077,000 | $90,839,999 | 2 | Walt Disney Studios Motion Pictures | - |
| 3 | 3 | - | Iron Man | $20,147,000 | $20,447,253 | +$300,253 | +1.5% | 3,915 | $252,314,000 | $252,614,669 | 4 | Paramount Pictures | - |
| 4 | 4 | - | What Happens in Vegas | $9,000,000 | $9,116,935 | +$116,935 | +1.3% | 3,188 | $54,246,000 | $54,362,827 | 3 | Twentieth Century Fox | - |
| 5 | 5 | - | Speed Racer | $4,000,000 | $3,942,756 | -$57,244 | -1.4% | 3,112 | $36,213,000 | $36,152,093 | 3 | Warner Bros. | - |
| 6 | 7 | +1 | Made of Honor | $3,400,000 | $3,350,618 | -$49,382 | -1.5% | 2,393 | $39,061,000 | $39,011,917 | 4 | Sony Pictures Releasing | - |
| 7 | 6 | -1 | Baby Mama | $3,323,000 | $3,355,690 | +$32,690 | +1% | 2,158 | $52,131,000 | $52,163,835 | 5 | Universal Pictures | - |
| 8 | 8 | - | Forgetting Sarah Marshall | $1,666,000 | $1,770,450 | +$104,450 | +6.3% | 1,073 | $58,195,000 | $58,299,420 | 6 | Universal Pictures | - |
| 9 | 9 | - | Harold & Kumar Escape from Guantanamo Bay | $915,000 | $927,336 | +$12,336 | +1.3% | 750 | $35,908,000 | $35,916,292 | 5 | Warner Bros. | - |
| 10 | 10 | - | The Visitor | $781,000 | $724,183 | -$56,817 | -7.3% | 270 | $4,432,000 | $4,375,408 | 7 | Overture Films | - |
| 11 | 13 | +2 | Then She Found Me | $398,819 | - | - | - | 150 | $2,077,029 | - | 5 | THINKFilm | - |
| 12 | 12 | - | The Forbidden Kingdom | $355,000 | $418,600 | +$63,600 | +17.9% | 487 | $51,158,000 | $51,221,203 | 6 | Lionsgate | - |
| 13 | 14 | +1 | Young@Heart | $320,000 | $321,695 | +$1,695 | +0.5% | 212 | $2,404,000 | $2,406,172 | 7 | Fox Searchlight Pictures | - |
| 14 | 18 | +4 | Son of Rambow | $235,000 | $241,335 | +$6,335 | +2.7% | 152 | $851,000 | $857,248 | 4 | Paramount Vantage | - |
| 15 | 25 | +10 | The Counterfeiters | $110,000 | $102,199 | -$7,801 | -7.1% | 107 | $5,021,000 | $5,012,534 | 14 | Sony Pictures Classics | - |
| 16 | 23 | +7 | Before the Rains | $108,000 | $106,641 | -$1,359 | -1.3% | 41 | $321,000 | $319,873 | 3 | Roadside Attractions | - |
| 17 | 24 | +7 | 10,000 BC | $104,000 | $104,783 | +$783 | +0.8% | 187 | $94,520,000 | $94,522,170 | 12 | Warner Bros. | - |
| 18 | 30 | +12 | Reprise | $92,600 | $84,521 | -$8,079 | -8.7% | 14 | $166,000 | $158,202 | 2 | Miramax | - |
| 19 | 28 | +9 | Leatherheads | $90,000 | $90,090 | +$90 | +0.1% | 182 | $31,095,000 | $31,095,490 | 8 | Universal Pictures | - |
| 20 | 29 | +9 | Superhero Movie | $84,000 | $86,773 | +$2,773 | +3.3% | 153 | $25,505,000 | $25,507,610 | 9 | Metro-Goldwyn-Mayer (MGM) | - |
| 21 | 37 | +16 | The Bank Job | $50,000 | $52,165 | +$2,165 | +4.3% | 122 | $29,937,000 | $29,939,217 | 12 | Lionsgate | - |
| 22 | 42 | +20 | The Children of Huang Shi | $47,900 | $42,755 | -$5,145 | -10.7% | 7 | $47,900 | $42,755 | 1 | Sony Pictures Classics | - |
| 23 | 40 | +17 | The Fall | $47,250 | $49,526 | +$2,276 | +4.8% | 20 | $260,000 | $261,777 | 3 | Roadside Attractions | - |
| 24 | 45 | +21 | War, Inc. | $36,500 | $35,336 | -$1,164 | -3.2% | 2 | $36,500 | $35,336 | 1 | First Look International | - |
| 25 | 47 | +22 | Expelled: No Intelligence Allowed | $30,300 | $35,109 | +$4,809 | +15.9% | 83 | $7,582,000 | $7,586,866 | 6 | Rocky Mountain Pictures | - |
