| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Indiana Jones and the Kingdom of the Crystal Skull | $898,345 | - | 85 | - | $10,568 | $898,345 | 1 | United International Pictures | true | false |
| 2 | 1 | Speed Racer | $240,847 | -40.2% | 91 | +6 | $2,646 | $1,443,900 | 3 | Warner Bros. | false | false |
| 3 | 3 | What Happens in Vegas | $123,859 | -20.6% | 30 | - | $4,128 | $316,168 | 2 | 20th Century Fox International | false | false |
| 4 | 2 | Iron Man | $96,872 | -48.7% | 81 | +6 | $1,195 | $1,377,866 | 4 | United International Pictures | false | false |
| 5 | 4 | Death at a Funeral | $95,570 | -14.6% | 33 | - | $2,896 | $1,641,964 | 12 | - | false | false |
| 6 | 7 | The Counterfeiters | $76,682 | -5.7% | 22 | +9 | $3,485 | $182,120 | 2 | Alfa Films | false | false |
| 7 | 5 | The Oxford Murders | $69,307 | -29% | 23 | - | $3,013 | $336,933 | 3 | Pachamama Cine | false | false |
| 8 | - | The Unknown Woman | $62,318 | - | 19 | - | $3,279 | $62,318 | 1 | Impacto Cine | true | false |
| 9 | 8 | Awake | $55,529 | -29.7% | 31 | - | $1,791 | $155,086 | 2 | Distribution Company | false | false |
| 10 | 6 | The Nest | $55,243 | -42.1% | 38 | - | $1,453 | $853,012 | 5 | Distribution Company | false | false |
| 11 | 9 | 21 | $37,304 | -28.3% | 37 | +1 | $1,008 | $669,818 | 6 | Sony Pictures Releasing | false | false |
| 12 | 10 | Shutter | $32,708 | -24.6% | 27 | - | $1,211 | $403,892 | 6 | 20th Century Fox International | false | false |
| 13 | 11 | Lamb of God | $16,225 | -49% | 10 | -3 | $1,622 | $117,746 | 3 | Alfa Films | false | false |
| 14 | 12 | Street Kings | $12,875 | -52.2% | 30 | - | $429 | $217,955 | 5 | 20th Century Fox International | false | false |
| 15 | 14 | Mrs Palfrey at the Claremont 2008 Re-release | $12,641 | -23.9% | 3 | - | $4,213 | $33,555 | 2 | Primer Plano Film Group | false | false |
| 16 | 16 | Conversations with My Gardener | $10,694 | -26% | 8 | -1 | $1,336 | $159,358 | 5 | Alfa Films | false | false |
| 17 | 15 | Yo soy sola | $6,244 | -59% | 6 | -4 | $1,040 | $26,404 | 2 | Alfa Films | false | false |
| 18 | 17 | Two Days in Paris | $5,532 | -41.7% | 8 | -1 | $691 | $347,410 | 9 | Impacto Cine | false | false |
| 19 | 20 | Horton Hears a Who! | $5,165 | -42.9% | 12 | -13 | $430 | $1,188,300 | 11 | 20th Century Fox International | false | false |
| 20 | 22 | We Own the Night | $5,120 | -28.5% | 8 | +1 | $640 | $73,403 | 4 | CDI Films | false | false |
| 21 | 18 | The Savages | $4,704 | -49.4% | 7 | -3 | $672 | $103,172 | 4 | 20th Century Fox International | false | false |
| 22 | 24 | P.S. I Love You | $4,125 | -18.3% | 9 | -2 | $458 | $441,442 | 13 | Alfa Films | false | false |
| 23 | 19 | The Orphanage | $3,593 | -60.9% | 13 | -4 | $276 | $719,133 | 11 | CDI Films | false | false |
| 24 | 13 | Untraceable | $3,392 | -81.2% | 6 | -23 | $565 | $184,135 | 5 | Sony Pictures Releasing | false | false |
| 25 | 29 | Evening | $3,357 | -4.8% | 9 | -2 | $373 | $181,411 | 7 | Impacto Cine | false | false |
| 26 | 37 | Caramel | $3,150 | +54.9% | 6 | - | $525 | $214,645 | 9 | Alfa Films | false | false |
| 27 | 27 | Persepolis | $2,813 | -30.1% | 4 | - | $703 | $40,757 | 5 | Sony Pictures Releasing | false | false |
| 28 | 35 | S.O.S. Ex | $2,475 | +2.7% | 3 | - | $825 | $5,726 | 2 | N/A | false | false |
| 29 | 21 | In the Valley of Elah | $2,300 | -72.4% | 5 | -8 | $460 | $282,184 | 8 | Alfa Films | false | false |
| 30 | 23 | Lust, Caution | $2,293 | -54.6% | 5 | -6 | $458 | $57,077 | 4 | Distribution Company | false | false |
| 31 | 25 | Jumper | $2,220 | -56% | 18 | -8 | $123 | $571,816 | 8 | 20th Century Fox International | false | false |
| 32 | 31 | The Game Plan | $1,424 | -47.9% | 10 | -13 | $142 | $1,447,249 | 15 | Walt Disney Pictures | false | false |
| 33 | 28 | Elizabeth: The Golden Age | $1,350 | -64.3% | 3 | -1 | $450 | $107,391 | 11 | United International Pictures | false | false |
| 34 | 26 | El desierto negro | $943 | -80.7% | 2 | - | $471 | $6,326 | 2 | N/A | false | false |
| 35 | 33 | Mr. Woodcock | $930 | -64.4% | 6 | -1 | $155 | $99,848 | 8 | Distribution Company | false | false |
| 36 | 34 | The Hunting Party | $882 | -63.6% | 6 | -4 | $147 | $306,200 | 10 | Distribution Company | false | false |
| 37 | 30 | 10,000 BC | $718 | -76% | 5 | -11 | $143 | $2,185,927 | 12 | Warner Bros. | false | false |
| 38 | 38 | No Country for Old Men | $689 | -63.8% | 5 | -13 | $137 | $955,870 | 12 | Walt Disney Pictures | false | false |
| 39 | 32 | The Spiderwick Chronicles | $682 | -75% | 7 | -12 | $97 | $658,052 | 10 | United International Pictures | false | false |
| 40 | 45 | Silk | $615 | -30.7% | 2 | - | $307 | $10,837 | 3 | Distribution Company | false | false |
| 41 | 41 | The Ugly Duckling and Me! | $478 | -61.5% | 5 | -5 | $95 | $74,426 | 10 | - | false | false |
| 42 | 52 | King of California | $436 | +146.3% | 2 | -1 | $218 | $64,329 | 7 | Distribution Company | false | false |
| 43 | 40 | Diary of the Dead | $265 | -79% | 2 | -2 | $132 | $288,929 | 10 | Pachamama Cine | false | false |
| 44 | 43 | Rancho aparte | $252 | -75.4% | 1 | -1 | $252 | $138,524 | 9 | - | false | false |
| 45 | 49 | There Will Be Blood | $205 | -3.3% | 1 | -1 | $205 | $502,428 | 14 | Walt Disney Pictures | false | false |
| 46 | 50 | Alvin and the Chipmunks | $187 | -10.1% | 3 | - | $62 | $796,358 | 21 | 20th Century Fox International | false | false |
| 47 | 44 | The Eye | $162 | -82.1% | 2 | -2 | $81 | $229,916 | 13 | United International Pictures | false | false |
| 48 | 53 | Juno | $101 | -39.9% | 1 | -1 | $101 | $462,549 | 15 | Alfa Films | false | false |
| 49 | 64 | Underdog | $90 | +291.3% | 2 | +1 | $45 | $848,915 | 34 | Walt Disney Pictures | false | false |
| 50 | 47 | The Water Horse | $75 | -74.7% | 1 | -1 | $75 | $590,676 | 16 | Sony Pictures Releasing | false | false |
| 51 | 48 | The Golden Compass | $72 | -66.4% | 1 | -2 | $72 | $1,387,437 | 24 | Distribution Company | false | false |
| 52 | 63 | Atonement | $51 | +59.4% | 1 | - | $51 | $503,445 | 16 | United International Pictures | false | false |
| 53 | 55 | Enchanted | $38 | -50% | 1 | -1 | $38 | $2,792,691 | 21 | Walt Disney Pictures | false | false |
| 54 | 60 | National Treasure: Book of Secrets | $13 | -70.5% | 1 | - | $13 | $1,660,784 | 19 | Walt Disney Pictures | false | false |
| 55 | 56 | Rain | $9 | -87.1% | 1 | -3 | $9 | $158,635 | 10 | Walt Disney Pictures | false | false |
