| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Iron Man | $3,752,544 | -2.8% | 496 | -3 | $7,565 | $25,428,851 | 3 | Paramount Pictures International | false | false |
| 2 | 2 | What Happens in Vegas | $2,962,017 | +20% | 405 | +7 | $7,313 | $6,871,966 | 2 | 20th Century Fox International | false | false |
| 3 | 3 | Forgetting Sarah Marshall | $1,117,171 | +9.1% | 395 | +14 | $2,828 | $12,622,585 | 4 | Universal Pictures International (UPI) | false | false |
| 4 | 5 | Nim's Island | $881,188 | +42.1% | 386 | -4 | $2,282 | $4,167,106 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | Speed Racer | $803,385 | +13.6% | 457 | +15 | $1,757 | $1,749,047 | 2 | Warner Bros. | false | false |
| 6 | 7 | Made of Honor | $557,699 | +2.4% | 324 | -23 | $1,721 | $3,805,042 | 3 | Sony Pictures Releasing | false | false |
| 7 | 6 | Doomsday | $495,633 | -18.5% | 259 | +2 | $1,913 | $1,480,340 | 2 | Universal Pictures International (UPI) | false | false |
| 8 | 8 | In Bruges | $261,845 | +29.8% | 150 | -13 | $1,745 | $8,870,900 | 11 | Universal Pictures International (UPI) | false | false |
| 9 | - | Caramel | $240,247 | - | 46 | - | $5,222 | $240,247 | 1 | Momentum Pictures | true | false |
| 10 | 9 | 21 | $190,162 | +8.6% | 130 | -47 | $1,462 | $10,625,461 | 6 | Sony Pictures Releasing | false | false |
| 11 | - | Charlie Bartlett | $190,141 | - | 202 | - | $941 | $190,141 | 1 | Verve Pictures | true | false |
| 12 | - | Smart People | $172,637 | - | 73 | - | $2,364 | $172,637 | 1 | Icon Film Distribution Australia | true | false |
| 13 | 10 | The Eye | $163,395 | -6% | 164 | -50 | $996 | $3,490,495 | 4 | Lionsgate | false | false |
| 14 | - | Shutter | $141,996 | - | 65 | - | $2,184 | $141,996 | 1 | 20th Century Fox International | true | false |
| 15 | 12 | Happy-Go-Lucky | $136,001 | +19.3% | 94 | +13 | $1,446 | $2,765,120 | 5 | Momentum Pictures | false | false |
| 16 | 13 | Persepolis | $116,568 | +10.4% | 45 | +6 | $2,590 | $1,235,729 | 4 | Optimum Releasing | false | false |
| 17 | - | Jannat: In Search of Heaven... | $96,371 | - | 21 | - | $4,589 | $96,371 | 1 | Tip Top Entertainment (TTE) | true | false |
| 18 | 11 | Bhoothnath | $90,309 | -29.3% | 34 | +1 | $2,656 | $278,083 | 2 | Eros Worldwide | false | false |
| 19 | - | Outpost | $75,656 | - | 51 | - | $1,483 | $75,656 | 1 | Vertigo Films | true | false |
| 20 | 26 | The Game Plan | $38,560 | +99.6% | 125 | +25 | $308 | $8,284,363 | 11 | Walt Disney Pictures | false | false |
| 21 | 17 | The Spiderwick Chronicles | $35,698 | -10.6% | 117 | -100 | $305 | $20,541,581 | 9 | Paramount Pictures International | false | false |
| 22 | 15 | Step Up 2: The Streets | $35,680 | -17.6% | 96 | -57 | $371 | $20,494,678 | 9 | Universal Pictures International (UPI) | false | false |
| 23 | - | Heartbeat Detector | $31,757 | - | 6 | - | $5,292 | $31,757 | 1 | Trinity Filmed Entertainment | true | false |
| 24 | 23 | Underdog | $28,996 | +32.9% | 61 | +9 | $475 | $2,776,787 | 16 | Walt Disney Pictures | false | false |
| 25 | 19 | Horton Hears a Who! | $28,754 | -8.6% | 94 | -76 | $305 | $16,611,914 | 9 | 20th Century Fox International | false | false |
| 26 | 14 | Where in the World Is Osama Bin Laden? | $27,834 | -46.3% | 33 | -5 | $843 | $113,379 | 2 | Optimum Releasing | false | false |
| 27 | 18 | Honeydripper | $25,531 | -33.4% | 17 | -1 | $1,501 | $91,321 | 2 | Axiom Films | false | false |
| 28 | 16 | Fool's Gold | $20,233 | -50.8% | 41 | -78 | $493 | $4,674,310 | 5 | Warner Bros. | false | false |
| 29 | 29 | The Oxford Murders | $18,806 | +37.3% | 20 | +7 | $940 | $415,171 | 4 | Odeon Sky Filmworks | false | false |
| 30 | 21 | Son of Rambow | $18,574 | -35.2% | 47 | -67 | $395 | $8,112,178 | 7 | Optimum Releasing | false | false |
| 31 | 24 | XXY | $17,613 | -18.1% | 8 | +1 | $2,201 | $54,653 | 2 | Peccadillo Pictures | false | false |
| 32 | 28 | A Secret | $15,496 | -0.2% | 2 | - | $7,748 | $40,565 | 2 | Arrow Films | false | false |
| 33 | 39 | The Other Boleyn Girl | $15,293 | +253.3% | 10 | +5 | $1,529 | $9,164,741 | 11 | Universal Pictures International (UPI) | false | false |
| 34 | 34 | The Orphanage | $11,698 | +90.6% | 11 | +2 | $1,063 | $3,388,947 | 9 | Optimum Releasing | false | false |
| 35 | 27 | Tashan | $11,235 | -40% | 18 | -8 | $624 | $682,463 | 4 | Yash Raj Films | false | false |
| 36 | 22 | Street Kings | $10,878 | -57.8% | 10 | -30 | $1,087 | $2,679,926 | 5 | 20th Century Fox International | false | false |
| 37 | 33 | The Diving Bell and the Butterfly | $10,745 | +55.5% | 6 | +3 | $1,790 | $1,664,702 | 15 | Pathé | false | false |
| 38 | 40 | Shine a Light | $9,239 | +115.6% | 12 | +5 | $769 | $1,261,242 | 6 | 20th Century Fox International | false | false |
| 39 | - | Some Came Running | $8,484 | - | 2 | - | $4,242 | $8,484 | 1 | British Film Institute (BFI) | true | false |
| 40 | 37 | Lars and the Real Girl | $8,429 | +72.1% | 10 | +4 | $842 | $822,905 | 9 | Verve Pictures | false | false |
| 41 | 41 | Welcome to the Sticks | $7,605 | +108.4% | 3 | - | $2,535 | $153,986 | 7 | Pathé | false | false |
| 42 | 20 | Kuruvi | $6,942 | -76.8% | 11 | -5 | $631 | $263,919 | 3 | Ayngaran International | false | false |
| 43 | - | Terror's Advocate | $5,850 | - | 2 | - | $2,925 | $5,850 | 1 | Artificial Eye | true | false |
| 44 | 30 | Manufactured Landscapes | $5,222 | -52.1% | 2 | -4 | $2,611 | $27,249 | 2 | British Film Institute (BFI) | false | false |
| 45 | 43 | The Bank Job | $4,870 | +42.3% | 2 | -1 | $2,435 | $7,960,655 | 12 | Lionsgate | false | false |
| 46 | 32 | My Brother is an Only Child | $4,774 | -44.8% | 5 | -3 | $954 | $610,487 | 7 | Revolver Entertainment | false | false |
| 47 | 45 | Leatherheads | $4,645 | +56.4% | 9 | +4 | $516 | $2,051,745 | 6 | Universal Pictures International (UPI) | false | false |
| 48 | 46 | Flashbacks of a Fool | $4,306 | +81.2% | 3 | - | $1,435 | $874,420 | 5 | Walt Disney Pictures | false | false |
| 49 | - | The Air I Breathe | $3,909 | - | 3 | - | $1,303 | $3,909 | 1 | Pathé | true | false |
| 50 | 42 | Love in the Time of Cholera | $2,667 | -26.9% | 3 | -5 | $889 | $706,809 | 9 | Momentum Pictures | false | false |
| 51 | 48 | The Ugly Duckling and Me! | $2,626 | +30.9% | 11 | -5 | $238 | $813,741 | 46 | Eclipse Pictures | false | false |
| 52 | 54 | Grindhouse | $2,037 | +53.4% | 5 | +2 | $407 | $174,432 | 8 | Momentum Pictures | false | false |
| 53 | 56 | The Conformist 2008 Re-release | $1,972 | +73.1% | 1 | -3 | $1,972 | $213,751 | 12 | British Film Institute (BFI) | false | false |
| 54 | 59 | You, the Living | $1,839 | +140.1% | 4 | +1 | $459 | $183,809 | 8 | Artificial Eye | false | false |
| 55 | 49 | Funny Games | $1,831 | -0.2% | 5 | +1 | $366 | $395,347 | 7 | Tartan | false | false |
| 56 | 35 | The Last Mistress | $1,704 | -69.8% | 3 | - | $568 | $70,209 | 6 | Artificial Eye | false | false |
| 57 | - | The Aerial | $1,522 | - | 1 | - | $1,522 | $1,522 | - | - | - | false |
| 58 | 53 | Vexille | $1,221 | -9.2% | 1 | - | $1,221 | $4,021 | 2 | Momentum Pictures | false | false |
| 59 | - | RFK Must Die: The Assassination of Bobby Kennedy | $1,141 | - | 2 | - | $570 | $1,141 | 1 | Soda Pictures | true | false |
| 60 | 60 | REC | $986 | +30.8% | 5 | +1 | $197 | $443,946 | 6 | Odeon Sky Filmworks | false | false |
| 61 | 61 | Death Note 2008 Re-release | $904 | +37.8% | 1 | - | $904 | $11,665 | 4 | Blue Dolphin Film Distribution | false | false |
| 62 | 31 | P2 | $900 | -90% | 6 | -28 | $150 | $139,178 | 3 | Tartan | false | false |
| 63 | 50 | Never Back Down | $751 | -51.3% | 4 | +1 | $187 | $4,232,733 | 7 | Momentum Pictures | false | false |
| 64 | 52 | Winter Soldier | $352 | -74.2% | 1 | - | $352 | $2,825 | 2 | Stoney Road Films | false | false |
| 65 | 58 | Mouth to Mouth 2008 Re-release | $221 | -76% | 1 | - | $221 | $1,667 | 2 | - | false | false |
| 66 | 69 | Still Life | $215 | +162.2% | 1 | - | $215 | $72,647 | 16 | British Film Institute (BFI) | false | false |
| 67 | 44 | Cashback | $182 | -93.9% | 1 | -3 | $182 | $6,103 | 2 | The Works UK Distribution | false | false |
| 68 | 70 | Flight of the Red Balloon | $76 | +33.3% | 1 | - | $76 | $88,650 | 10 | Park Circus | false | false |
| 69 | 66 | Azur & Asmar: The Princes' Quest | $47 | -77.3% | 2 | - | $23 | $68,261 | 15 | Soda Pictures | false | false |
| 70 | 62 | The 39 Steps 2008 Re-release | $39 | -92.7% | 1 | - | $39 | $47,265 | 6 | Park Circus | false | false |
| 71 | - | Away from Her | $39 | - | 1 | - | $39 | $302,013 | 14 | Metrodome Distribution | false | false |
| 72 | 64 | I'm a Cyborg, But That's OK | $39 | -86.7% | 1 | - | $39 | $21,548 | 7 | Tartan | false | false |
| 73 | 74 | 4 Months, 3 Weeks and 2 Days | $39 | - | 1 | - | $39 | $582,095 | 20 | Artificial Eye | false | false |
| 74 | 65 | The Edge of Heaven | $39 | -81.5% | 1 | - | $39 | $275,508 | 13 | Artificial Eye | false | false |
| 75 | 71 | Redacted | $35 | -10.3% | 1 | - | $35 | $38,722 | 10 | Optimum Releasing | false | false |
