| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Iron Man | $50,500,000 | $51,190,629 | +$690,629 | +1.4% | 4,111 | $177,134,000 | $177,825,024 | 2 | Paramount Pictures | - |
| 2 | 3 | +1 | Speed Racer | $20,210,000 | $18,561,337 | -$1,648,663 | -8.2% | 3,606 | $20,210,000 | $18,561,337 | 1 | Warner Bros. | - |
| 3 | 2 | -1 | What Happens in Vegas | $20,000,000 | $20,172,474 | +$172,474 | +0.9% | 3,215 | $20,000,000 | $20,172,474 | 1 | Twentieth Century Fox | - |
| 4 | 4 | - | Made of Honor | $7,600,000 | $8,116,323 | +$516,323 | +6.8% | 2,734 | $26,275,000 | $26,791,494 | 2 | Sony Pictures Releasing | - |
| 5 | 5 | - | Baby Mama | $5,766,000 | $6,225,790 | +$459,790 | +8% | 2,627 | $40,377,000 | $40,836,370 | 3 | Universal Pictures | - |
| 6 | 6 | - | Forgetting Sarah Marshall | $3,778,000 | $3,837,240 | +$59,240 | +1.6% | 2,376 | $50,772,000 | $50,781,745 | 4 | Universal Pictures | - |
| 7 | 7 | - | Harold & Kumar Escape from Guantanamo Bay | $3,155,000 | $3,106,424 | -$48,576 | -1.5% | 2,264 | $30,716,000 | $30,667,308 | 3 | Warner Bros. | - |
| 8 | 8 | - | The Forbidden Kingdom | $1,900,000 | $2,169,323 | +$269,323 | +14.2% | 1,724 | $48,261,000 | $48,530,104 | 4 | Lionsgate | - |
| 9 | 9 | - | Nim's Island | $1,325,000 | $1,463,622 | +$138,622 | +10.5% | 1,601 | $44,257,000 | $44,395,857 | 6 | Twentieth Century Fox | - |
| 10 | 10 | - | Redbelt | $1,140,000 | - | - | - | 1,379 | $1,237,000 | - | 2 | Sony Pictures Classics | - |
| 11 | 11 | - | Prom Night | $1,050,000 | $1,012,986 | -$37,014 | -3.5% | 1,465 | $42,822,000 | $42,785,107 | 5 | Screen Gems | - |
| 12 | 12 | - | 21 | $835,000 | $851,385 | +$16,385 | +2% | 978 | $80,418,000 | $80,434,035 | 7 | Sony Pictures Releasing | - |
| 13 | 13 | - | The Visitor | $764,000 | $729,212 | -$34,788 | -4.6% | 217 | $2,510,000 | $2,475,492 | 5 | Overture Films | - |
| 14 | 14 | - | Horton Hears a Who! | $575,000 | $605,347 | +$30,347 | +5.3% | 770 | $150,669,000 | $150,699,120 | 9 | Twentieth Century Fox | - |
| 15 | 17 | +2 | Then She Found Me | $489,000 | - | - | - | 153 | $912,000 | - | 3 | THINKFilm | - |
| 16 | 15 | -1 | 88 Minutes | $485,000 | $534,104 | +$49,104 | +10.1% | 625 | $16,411,000 | $16,460,014 | 4 | Sony Pictures Releasing | - |
| 17 | 18 | +1 | Young@Heart | $355,000 | $388,928 | +$33,928 | +9.6% | 145 | $1,411,000 | $1,444,646 | 5 | Fox Searchlight Pictures | - |
| 18 | 21 | +3 | Expelled: No Intelligence Allowed | $302,000 | $328,836 | +$26,836 | +8.9% | 402 | $7,208,000 | $7,235,324 | 4 | Rocky Mountain Pictures | - |
| 19 | 23 | +4 | Leatherheads | $212,000 | $239,445 | +$27,445 | +12.9% | 424 | $30,703,000 | $30,730,820 | 6 | Universal Pictures | - |
| 20 | 25 | +5 | The Counterfeiters | $165,000 | $148,775 | -$16,225 | -9.8% | 122 | $4,679,000 | $4,661,883 | 12 | Sony Pictures Classics | - |
| 21 | 24 | +3 | Son of Rambow | $138,000 | $159,834 | +$21,834 | +15.8% | 36 | $211,000 | $232,837 | 2 | Paramount Vantage | - |
| 22 | 31 | +9 | Under the Same Moon | $82,500 | $98,682 | +$16,182 | +19.6% | 138 | $12,257,000 | $12,273,323 | 8 | The Weinstein Company | - |
| 23 | 32 | +9 | Fugitive Pieces | $82,400 | $86,402 | +$4,002 | +4.9% | 38 | $216,000 | $219,576 | 2 | The Samuel Goldwyn Company | - |
| 24 | 34 | +10 | The Fall | $80,200 | $79,611 | -$589 | -0.7% | 9 | $80,200 | $79,611 | 1 | Roadside Attractions | - |
| 25 | 35 | +10 | Priceless | $76,000 | $76,895 | +$895 | +1.2% | 38 | $1,365,000 | $1,365,673 | 7 | The Samuel Goldwyn Company | - |
| 26 | 41 | +15 | Roman de gare | $64,000 | $64,516 | +$516 | +0.8% | 15 | $334,000 | $334,098 | 3 | The Samuel Goldwyn Company | - |
| 27 | 36 | +9 | Superhero Movie | $63,000 | $73,170 | +$10,170 | +16.1% | 131 | $25,370,000 | $25,380,619 | 7 | Metro-Goldwyn-Mayer (MGM) | - |
| 28 | 39 | +11 | Never Back Down | $60,000 | $69,460 | +$9,460 | +15.8% | 120 | $24,676,000 | $24,685,255 | 9 | Summit Entertainment | - |
| 29 | 52 | +23 | The Bank Job | $56,000 | $37,490 | -$18,510 | -33.1% | 64 | $29,817,000 | $29,798,098 | 10 | Lionsgate | - |
| 30 | 48 | +18 | Before the Rains | $52,300 | $48,159 | -$4,141 | -7.9% | 8 | $52,300 | $48,159 | 1 | Roadside Attractions | - |
| 31 | 45 | +14 | My Blueberry Nights | $52,200 | $56,806 | +$4,606 | +8.8% | 57 | $547,000 | $551,857 | 6 | The Weinstein Company | - |
| 32 | 46 | +14 | Miss Pettigrew Lives for a Day | $44,800 | $49,873 | +$5,073 | +11.3% | 98 | $12,224,000 | $12,229,144 | 10 | Focus Features | - |
| 33 | 51 | +18 | In Bruges | $39,800 | $39,814 | +$14 | <0.1% | 57 | $7,551,000 | $7,550,836 | 14 | Focus Features | - |
| 34 | 55 | +21 | Standard Operating Procedure | $30,800 | $26,701 | -$4,099 | -13.3% | 21 | $100,000 | $96,234 | 3 | Sony Pictures Classics | - |
| 35 | 61 | +26 | Penelope | $18,000 | $19,836 | +$1,836 | +10.2% | 44 | $9,984,000 | $9,985,759 | 11 | Summit Entertainment | - |
| 36 | 65 | +29 | Mister Lonely | $18,000 | $18,389 | +$389 | +2.2% | 5 | $41,100 | $41,520 | 2 | IFC Films | - |
| 37 | 72 | +35 | My Brother is an Only Child | $13,800 | $12,189 | -$1,611 | -11.7% | 9 | $143,000 | $141,623 | 7 | THINKFilm | - |
| 38 | 75 | +37 | The Year My Parents Went on Vacation | $10,100 | $10,176 | +$76 | +0.8% | 16 | $714,000 | $714,371 | 13 | City Lights Pictures | - |
| 39 | 91 | +52 | Where in the World Is Osama Bin Laden? | $4,800 | $5,152 | +$352 | +7.3% | 17 | $322,000 | $322,710 | 4 | The Weinstein Company | - |
| 40 | 99 | +59 | Noise | $4,050 | $3,687 | -$363 | -9% | 2 | $4,050 | $3,687 | 1 | THINKFilm | - |
| 41 | 102 | +61 | The Tracey Fragments | $3,330 | $3,002 | -$328 | -9.8% | 1 | $36,500 | $28,578 | 1 | THINKFilm | - |
