| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Iron Man | $3,861,537 | -64.2% | 499 | -1 | $7,738 | $19,847,142 | 2 | Paramount Pictures International | false | false |
| 2 | - | What Happens in Vegas | $2,467,460 | - | 398 | - | $6,199 | $2,467,460 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | Forgetting Sarah Marshall | $1,024,274 | -60.9% | 381 | -10 | $2,688 | $10,917,824 | 3 | Universal Pictures International (UPI) | false | false |
| 4 | - | Speed Racer | $707,369 | - | 442 | - | $1,600 | $707,369 | 1 | Warner Bros. | true | false |
| 5 | 3 | Nim's Island | $620,248 | -61.6% | 390 | -3 | $1,590 | $3,147,720 | 2 | Universal Pictures International (UPI) | false | false |
| 6 | - | Doomsday | $608,289 | - | 257 | - | $2,366 | $608,289 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 4 | Made of Honor | $544,366 | -63.2% | 347 | -1 | $1,568 | $2,897,181 | 2 | Sony Pictures Releasing | false | false |
| 8 | 7 | In Bruges | $201,703 | -65.5% | 163 | -70 | $1,237 | $8,451,709 | 10 | Universal Pictures International (UPI) | false | false |
| 9 | 6 | 21 | $175,144 | -72.2% | 177 | -124 | $989 | $10,315,245 | 5 | Sony Pictures Releasing | false | false |
| 10 | 5 | The Eye | $173,821 | -75.9% | 214 | -141 | $812 | $3,223,159 | 3 | Lionsgate Films | false | false |
| 11 | - | Bhoothnath | $127,693 | - | 33 | - | $3,869 | $127,693 | 1 | Eros Worldwide | true | false |
| 12 | 9 | Happy-Go-Lucky | $114,032 | -67.6% | 81 | -28 | $1,407 | $2,522,586 | 4 | Momentum Pictures | false | false |
| 13 | 10 | Persepolis | $105,587 | -57.6% | 39 | -8 | $2,707 | $1,021,016 | 3 | Optimum Releasing | false | false |
| 14 | - | Where in the World Is Osama Bin Laden? | $51,866 | - | 38 | - | $1,364 | $51,866 | 1 | Optimum Releasing | true | false |
| 15 | 13 | Step Up 2: The Streets | $43,309 | -77.7% | 153 | -120 | $283 | $20,417,820 | 8 | Universal Pictures International (UPI) | false | false |
| 16 | 8 | Fool's Gold | $41,088 | -89% | 119 | -185 | $345 | $4,619,551 | 4 | Warner Bros. | false | false |
| 17 | 12 | The Spiderwick Chronicles | $39,918 | -79.5% | 217 | -134 | $183 | $20,470,471 | 8 | Paramount Pictures International | false | false |
| 18 | - | Honeydripper | $38,336 | - | 18 | - | $2,129 | $38,336 | 1 | Axiom Films | true | false |
| 19 | 17 | Horton Hears a Who! | $31,463 | -72.3% | 170 | -85 | $185 | $16,555,173 | 8 | 20th Century Fox International | false | false |
| 20 | 15 | Kuruvi | $29,971 | -80.3% | 16 | +3 | $1,873 | $246,116 | 2 | Ayngaran International | false | false |
| 21 | 11 | Son of Rambow | $28,664 | -86.2% | 114 | -138 | $251 | $8,066,347 | 6 | Optimum Releasing | false | false |
| 22 | 16 | Street Kings | $25,780 | -79.9% | 40 | -95 | $644 | $2,649,023 | 4 | 20th Century Fox International | false | false |
| 23 | 23 | Underdog | $21,819 | -47% | 52 | -7 | $419 | $2,741,881 | 15 | Walt Disney Pictures | false | false |
| 24 | - | XXY | $21,502 | - | 7 | - | $3,071 | $21,502 | 1 | Peccadillo Pictures | true | false |
| 25 | 14 | Deception | $20,488 | -87.4% | 30 | -183 | $682 | $1,019,414 | 3 | Entertainment Film Distributors | false | false |
| 26 | 27 | The Game Plan | $19,322 | -6.9% | 100 | +34 | $193 | $8,231,727 | 10 | Walt Disney Pictures | false | false |
| 27 | 18 | Tashan | $18,718 | -83.1% | 26 | -17 | $719 | $658,584 | 3 | Yash Raj Films | false | false |
| 28 | - | A Secret | $15,534 | - | 2 | - | $7,767 | $15,534 | 1 | Arrow Films | true | false |
| 29 | 19 | The Oxford Murders | $13,698 | -82.6% | 13 | -38 | $1,053 | $384,186 | 3 | - | false | false |
| 30 | - | Manufactured Landscapes | $10,908 | - | 6 | - | $1,818 | $10,908 | 1 | British Film Institute (BFI) | true | false |
| 31 | 20 | P2 | $8,971 | -87.6% | 34 | -90 | $263 | $133,624 | 2 | Tartan | false | false |
| 32 | 31 | My Brother is an Only Child | $8,648 | -24% | 8 | - | $1,081 | $595,607 | 6 | Revolver Entertainment | false | false |
| 33 | 40 | The Diving Bell and the Butterfly | $6,910 | +10.8% | 3 | -6 | $2,303 | $1,643,557 | 14 | Pathé | false | false |
| 34 | 26 | The Orphanage | $6,136 | -71.3% | 9 | -8 | $681 | $3,364,493 | 8 | Optimum Releasing | false | false |
| 35 | 51 | The Last Mistress | $5,646 | +87.7% | 3 | +2 | $1,882 | $63,505 | 5 | Artificial Eye | false | false |
| 36 | 28 | U2 3D | $5,532 | -72.3% | 1 | -2 | $5,532 | $1,379,646 | 12 | Revolver Entertainment | false | false |
| 37 | 42 | Lars and the Real Girl | $4,897 | -1.1% | 6 | -2 | $816 | $809,711 | 8 | Verve Pictures | false | false |
| 38 | 24 | Mr. White Mr. Black | $4,618 | -84.5% | 8 | -3 | $577 | $51,321 | 2 | Eros Worldwide | false | false |
| 39 | 35 | The Other Boleyn Girl | $4,329 | -50% | 5 | -1 | $865 | $9,121,008 | 10 | Universal Pictures International (UPI) | false | false |
| 40 | 22 | Shine a Light | $4,286 | -89.9% | 7 | -1 | $612 | $1,244,452 | 5 | 20th Century Fox International | false | false |
| 41 | 32 | Welcome to the Sticks | $3,649 | -63.2% | 3 | -2 | $1,216 | $143,530 | 6 | Pathé | false | false |
| 42 | 48 | Love in the Time of Cholera | $3,647 | +3.6% | 8 | +5 | $455 | $699,598 | 8 | Momentum Pictures | false | false |
| 43 | 41 | The Bank Job | $3,423 | -42.7% | 3 | -3 | $1,141 | $7,940,965 | 11 | Lionsgate Films | false | false |
| 44 | - | Cashback | $2,987 | - | 4 | - | $746 | $2,987 | 1 | The Works UK Distribution | true | false |
| 45 | 33 | Leatherheads | $2,969 | -69.7% | 5 | -7 | $593 | $2,038,363 | 5 | Universal Pictures International (UPI) | false | false |
| 46 | 30 | Flashbacks of a Fool | $2,377 | -79.5% | 3 | -12 | $792 | $866,361 | 4 | Walt Disney Pictures | false | false |
| 47 | 36 | There Will Be Blood | $2,159 | -74.9% | 1 | -4 | $2,159 | $9,189,480 | 14 | Walt Disney Pictures | false | false |
| 48 | 59 | The Ugly Duckling and Me! | $2,006 | +53% | 16 | +7 | $125 | $809,848 | 45 | Eclipse Pictures | false | false |
| 49 | 55 | Funny Games | $1,834 | +9.1% | 4 | +1 | $458 | $390,098 | 6 | Tartan | false | false |
| 50 | 45 | Never Back Down | $1,543 | -61.8% | 3 | -16 | $514 | $4,225,106 | 6 | Momentum Pictures | false | false |
| 51 | - | I Served the King of England | $1,407 | - | 1 | - | $1,407 | $1,407 | 1 | Arrow Films | true | false |
| 52 | - | Winter Soldier | $1,364 | - | 1 | - | $1,364 | $1,364 | 1 | - | true | false |
| 53 | - | Vexille | $1,344 | - | 1 | - | $1,344 | $1,344 | 1 | Momentum Pictures | true | false |
| 54 | 47 | Grindhouse | $1,328 | -65.1% | 3 | -3 | $442 | $168,779 | 7 | Momentum Pictures | false | false |
| 55 | 38 | Drillbit Taylor | $1,248 | -84.6% | 12 | -12 | $104 | $4,452,750 | 7 | Paramount Pictures International | false | false |
| 56 | 65 | The Conformist 2008 Re-release | $1,139 | +189.1% | 4 | +3 | $284 | $209,322 | 11 | British Film Institute (BFI) | false | false |
| 57 | 44 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $953 | -77.7% | 4 | -4 | $238 | $1,548,002 | 9 | Walt Disney Pictures | false | false |
| 58 | - | Mouth to Mouth 2008 Re-release | $920 | - | 1 | - | $920 | $920 | 1 | Periscoop Film | true | false |
| 59 | 46 | You, the Living | $766 | -79.9% | 3 | -1 | $255 | $179,562 | 7 | Artificial Eye | false | false |
| 60 | 50 | REC | $754 | -77.2% | 4 | -5 | $188 | $442,268 | 5 | - | false | false |
| 61 | 56 | Death Note 2008 Re-release | $656 | -59.6% | 1 | - | $656 | $10,020 | 3 | - | false | false |
| 62 | 58 | The 39 Steps 2008 Re-release | $531 | -64% | 1 | - | $531 | $45,763 | 5 | Park Circus | false | false |
| 63 | 39 | Private Property | $377 | -94.2% | 1 | -2 | $377 | $41,901 | 4 | Soda Pictures | false | false |
| 64 | 70 | I'm a Cyborg, But That's OK | $293 | +651.3% | 1 | - | $293 | $21,307 | 6 | Tartan | false | false |
| 65 | 64 | The Edge of Heaven | $211 | -52.6% | 1 | -1 | $211 | $274,683 | 12 | Artificial Eye | false | false |
| 66 | 60 | Azur & Asmar: The Princes' Quest | $207 | -79.8% | 2 | -3 | $103 | $68,045 | 14 | Soda Pictures | false | false |
| 67 | 25 | A Deal Is a Deal | $143 | -99.5% | 2 | -107 | $71 | $606,968 | 3 | Worldwide Bonus Entertainment | false | false |
| 68 | 71 | My Blueberry Nights | $88 | +125.6% | 1 | - | $88 | $549,127 | 12 | Optimum Releasing | false | false |
| 69 | 61 | Still Life | $82 | -90.8% | 1 | - | $82 | $71,584 | 15 | British Film Institute (BFI) | false | false |
| 70 | 52 | Flight of the Red Balloon | $57 | -97.7% | 1 | -3 | $57 | $88,351 | 9 | Park Circus | false | false |
| 71 | 68 | Redacted | $39 | - | 1 | - | $39 | $38,631 | 9 | Optimum Releasing | false | false |
| 72 | 62 | Beaufort | $39 | -94.7% | 1 | -2 | $39 | $24,688 | 7 | Trinity Filmed Entertainment | false | false |
| 73 | 63 | Mister Lonely | $39 | -94.6% | 1 | - | $39 | $27,240 | 9 | Tartan | false | false |
| 74 | - | 4 Months, 3 Weeks and 2 Days | $39 | - | 1 | - | $39 | $580,139 | 19 | Artificial Eye | false | false |
