| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Horton Hears a Who! | $147,272 | - | 86 | - | $1,712 | $510,381 | 2 | NuMetro Distribution | false | false |
| 2 | - | The Game Plan | $120,542 | - | 55 | - | $2,191 | $841,691 | 3 | Ster-Kinekor Pictures | false | false |
| 3 | - | Vantage Point | $114,942 | - | 45 | - | $2,554 | $115,868 | 1 | United International Pictures | true | false |
| 4 | - | Step Up 2: The Streets | $111,743 | - | 52 | - | $2,148 | $1,037,166 | 4 | NuMetro Distribution | false | false |
| 5 | - | 10,000 BC | $65,720 | - | 55 | - | $1,194 | $566,744 | 3 | NuMetro Distribution | false | false |
| 6 | - | The Nanny Diaries | $61,948 | - | 40 | - | $1,548 | $213,126 | 2 | Ster-Kinekor Pictures | false | false |
| 7 | - | Fool's Gold | $61,414 | - | 55 | - | $1,116 | $793,425 | 5 | NuMetro Distribution | false | false |
| 8 | - | Why Did I Get Married? | $36,159 | - | 25 | - | $1,446 | $518,928 | 6 | Ster-Kinekor Pictures | false | false |
| 9 | - | Juno | $33,773 | - | 32 | - | $1,055 | $322,437 | 4 | NuMetro Distribution | false | false |
| 10 | - | The Spiderwick Chronicles | $33,637 | - | 49 | - | $686 | $285,413 | 3 | United International Pictures | false | false |
| 11 | - | One Missed Call | $16,825 | - | 20 | - | $841 | $195,536 | 4 | NuMetro Distribution | false | false |
| 12 | - | Sydney White | $13,448 | - | 23 | - | $584 | $374,413 | 6 | NuMetro Distribution | false | false |
| 13 | - | Scoop | $12,371 | - | 10 | - | $1,237 | $12,371 | 1 | Ster-Kinekor Pictures | true | false |
| 14 | - | No Country for Old Men | $11,649 | - | 11 | - | $1,059 | $178,808 | 6 | United International Pictures | false | false |
| 15 | - | Jumper | $11,130 | - | 21 | - | $530 | $875,373 | 8 | NuMetro Distribution | false | false |
| 16 | - | The Kite Runner | $10,366 | - | 8 | - | $1,295 | $237,579 | 8 | United International Pictures | false | false |
| 17 | - | Race | $9,531 | - | 9 | - | $1,059 | $89,307 | 3 | Ster-Kinekor Pictures | false | false |
| 18 | - | Planet Terror | $8,017 | - | 13 | - | $616 | $13,539 | 1 | Ster-Kinekor Pictures | true | false |
| 19 | - | Grace Is Gone | $7,275 | - | 10 | - | $727 | $31,984 | 2 | Ster-Kinekor Pictures | false | false |
| 20 | - | The Water Horse | $6,456 | - | 14 | - | $461 | $249,589 | 5 | United International Pictures | false | false |
| 21 | - | Atonement | $6,441 | - | 10 | - | $644 | $374,352 | 10 | United International Pictures | false | false |
| 22 | - | Charlie Wilson's War | $3,022 | - | 5 | - | $604 | $150,749 | 5 | United International Pictures | false | false |
| 23 | - | Love in the Time of Cholera | $2,155 | - | 6 | - | $359 | $66,636 | 4 | United International Pictures | false | false |
| 24 | - | Walk Hard: The Dewey Cox Story | $1,273 | - | 5 | - | $254 | $6,850 | 2 | United International Pictures | false | false |
| 25 | - | Good Luck Chuck | $544 | - | 4 | - | $136 | $398,066 | 11 | United International Pictures | false | false |
| 26 | - | Things We Lost in the Fire | $124 | - | 1 | - | $124 | $19,203 | 7 | United International Pictures | false | false |
