| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | 10,000 BC | $26,650 | -58.8% | 7 | - | $3,807 | $105,862 | 2 | N/A | false | false |
| 2 | 2 | Horton Hears a Who! | $8,275 | -54.5% | 8 | - | $1,034 | $59,860 | 3 | N/A | false | false |
| 3 | - | Saw IV | $5,679 | - | 5 | - | $1,135 | $5,679 | 1 | N/A | true | false |
| 4 | 3 | An American Haunting | $4,923 | -34.6% | 2 | - | $2,461 | $13,740 | 2 | N/A | false | false |
| 5 | 4 | Meet the Spartans | $3,810 | -31.8% | 4 | - | $952 | $45,343 | 4 | N/A | false | false |
| 6 | - | American Gangster | $2,621 | - | 2 | - | $1,310 | $2,621 | 1 | N/A | true | false |
| 7 | 6 | Love in the Time of Cholera | $2,124 | -38.3% | 3 | -1 | $708 | $69,844 | 6 | N/A | false | false |
| 8 | 5 | One Missed Call | $1,904 | -50.6% | 1 | -2 | $1,904 | $47,424 | 5 | N/A | false | false |
| 9 | 7 | The Bucket List | $1,208 | -59.9% | 2 | - | $604 | $62,767 | 8 | N/A | false | false |
| 10 | 9 | The Borgia | $971 | -44.2% | 2 | - | $485 | $11,026 | 4 | N/A | false | false |
| 11 | 10 | The Assassination of Jesse James by the Coward Robert Ford | $684 | -50.1% | 2 | - | $342 | $6,007 | 3 | N/A | false | false |
| 12 | 8 | The Game Plan | $585 | -72% | 1 | - | $585 | $84,283 | 9 | N/A | false | false |
