| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | The Bucket List | $19,540,000 | $19,392,416 | -$147,584 | -0.8% | 2,911 | $20,964,000 | $20,816,129 | 3 | Warner Bros. | - |
| 2 | 2 | - | First Sunday | $19,000,000 | $17,714,821 | -$1,285,179 | -6.8% | 2,213 | $19,000,000 | $17,714,821 | 1 | Screen Gems | - |
| 3 | 3 | - | Juno | $14,000,000 | $13,612,682 | -$387,318 | -2.8% | 2,448 | $71,250,000 | $70,862,478 | 6 | Fox Searchlight Pictures | - |
| 4 | 4 | - | National Treasure: Book of Secrets | $11,482,000 | $11,302,002 | -$179,998 | -1.6% | 3,377 | $187,295,000 | $187,114,947 | 4 | Walt Disney Studios Motion Pictures | - |
| 5 | 5 | - | Alvin and the Chipmunks | $9,100,000 | $9,302,895 | +$202,895 | +2.2% | 3,384 | $187,740,000 | $187,943,374 | 5 | Twentieth Century Fox | - |
| 6 | 6 | - | I Am Legend | $8,130,000 | $8,179,610 | +$49,610 | +0.6% | 3,353 | $240,234,000 | $240,283,451 | 5 | Warner Bros. | - |
| 7 | 7 | - | One Missed Call | $6,130,000 | $5,981,373 | -$148,627 | -2.4% | 2,240 | $20,642,000 | $20,493,337 | 2 | Warner Bros. | - |
| 8 | 8 | - | P.S. I Love You | $5,005,000 | $4,827,212 | -$177,788 | -3.6% | 2,323 | $47,008,000 | $46,830,324 | 4 | Warner Bros. | - |
| 9 | 9 | - | The Pirates Who Don't Do Anything: A VeggieTales Movie | $4,419,000 | $4,251,320 | -$167,680 | -3.8% | 1,337 | $4,419,000 | $4,251,320 | 1 | Universal Pictures | - |
| 10 | 10 | - | Atonement | $4,300,000 | $4,221,866 | -$78,134 | -1.8% | 950 | $25,208,000 | $25,130,656 | 6 | Focus Features | - |
| 11 | 11 | - | Charlie Wilson's War | $4,274,000 | $4,129,720 | -$144,280 | -3.4% | 2,408 | $59,498,000 | $59,353,790 | 4 | Universal Pictures | - |
| 12 | 12 | - | Sweeney Todd: The Demon Barber of Fleet Street | $3,402,000 | $3,385,171 | -$16,829 | -0.5% | 1,323 | $44,070,000 | $44,053,400 | 4 | DreamWorks | - |
| 13 | 13 | - | The Water Horse | $3,300,000 | $3,332,323 | +$32,323 | +1% | 2,506 | $35,175,000 | $35,206,965 | 3 | Revolution Studios | - |
| 14 | 14 | - | In the Name of the King: A Dungeon Siege Tale | $3,265,000 | - | - | - | 1,632 | $3,265,000 | - | 1 | Freestyle Releasing | - |
| 15 | 15 | - | The Great Debaters | $2,411,000 | $2,345,375 | -$65,625 | -2.7% | 1,290 | $25,699,000 | $25,633,630 | 3 | Metro-Goldwyn-Mayer (MGM) | - |
| 16 | 16 | - | The Orphanage | $2,044,000 | $2,015,605 | -$28,395 | -1.4% | 707 | $3,187,000 | $3,159,345 | 3 | Picturehouse | - |
| 17 | 17 | - | There Will Be Blood | $1,940,000 | $1,860,333 | -$79,667 | -4.1% | 129 | $4,358,000 | $4,277,973 | 3 | Paramount Vantage | - |
| 18 | 18 | - | Enchanted | $1,703,000 | $1,805,534 | +$102,534 | +6% | 1,201 | $122,290,000 | $122,392,372 | 8 | Walt Disney Studios Motion Pictures | - |
| 19 | 20 | +1 | The Kite Runner | $1,671,000 | $1,604,411 | -$66,589 | -4% | 715 | $11,005,000 | $10,938,680 | 5 | Paramount Vantage | - |
| 20 | 19 | -1 | Aliens vs. Predator: Requiem | $1,500,000 | $1,803,056 | +$303,056 | +20.2% | 1,378 | $40,081,000 | $40,383,929 | 3 | Twentieth Century Fox | - |
| 21 | 21 | - | No Country for Old Men | $1,284,000 | - | - | - | 657 | $46,835,000 | - | 10 | Miramax | - |
| 22 | 22 | - | The Golden Compass | $1,155,000 | - | - | - | 816 | $67,576,000 | - | 6 | New Line Cinema | - |
| 23 | 23 | - | The Diving Bell and the Butterfly | $375,000 | $347,440 | -$27,560 | -7.3% | 75 | $1,991,000 | $1,963,252 | 7 | Miramax | - |
| 24 | 24 | - | The Savages | $301,000 | $305,157 | +$4,157 | +1.4% | 92 | $3,004,000 | $3,008,480 | 7 | Fox Searchlight Pictures | - |
| 25 | 28 | +3 | Persepolis | $195,000 | $186,734 | -$8,266 | -4.2% | 18 | $548,000 | $540,085 | 3 | Sony Pictures Classics | - |
| 26 | 29 | +3 | American Gangster | $179,000 | $174,825 | -$4,175 | -2.3% | 282 | $129,772,000 | $129,767,770 | 11 | Universal Pictures | - |
| 27 | 37 | +10 | Before the Devil Knows You're Dead | $95,200 | $93,891 | -$1,309 | -1.4% | 95 | $6,807,000 | $6,806,048 | 12 | THINKFilm | - |
| 28 | 38 | +10 | I'm Not There | $77,000 | $82,723 | +$5,723 | +7.4% | 62 | $3,430,000 | $3,436,301 | 8 | The Weinstein Company | - |
| 29 | 47 | +18 | Lars and the Real Girl | $29,000 | $26,591 | -$2,409 | -8.3% | 36 | $5,805,000 | $5,802,820 | 14 | Metro-Goldwyn-Mayer (MGM) | - |
| 30 | 46 | +16 | Awake | $25,000 | $29,334 | +$4,334 | +17.3% | 41 | $14,180,000 | $14,183,857 | 7 | Metro-Goldwyn-Mayer (MGM) | - |
| 31 | 50 | +19 | Starting Out in the Evening | $24,500 | $23,707 | -$793 | -3.2% | 16 | $570,000 | $568,917 | 8 | Roadside Attractions | - |
| 32 | 51 | +19 | The Mist | $22,000 | $21,441 | -$559 | -2.5% | 49 | $25,366,000 | $25,365,040 | 8 | Metro-Goldwyn-Mayer (MGM) | - |
| 33 | 53 | +20 | Nanking | $18,700 | $19,331 | +$631 | +3.4% | 3 | $44,800 | $45,543 | 5 | THINKFilm | - |
| 34 | 60 | +26 | Bella | $14,400 | $13,792 | -$608 | -4.2% | 34 | $7,661,000 | $7,659,947 | 12 | Roadside Attractions | - |
| 35 | 61 | +26 | Lust, Caution | $14,400 | $10,988 | -$3,412 | -23.7% | 9 | $4,589,000 | $4,586,070 | 16 | Focus Features | - |
| 36 | 93 | +57 | Lions for Lambs | $700 | $526 | -$174 | -24.9% | 4 | $14,940,000 | $14,939,738 | 10 | United Artists | - |
