| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | National Treasure: Book of Secrets | $35,632,000 | $35,672,708 | +$40,708 | +0.1% | 3,832 | $124,035,000 | $124,075,411 | 2 | Walt Disney Studios Motion Pictures | - |
| 2 | 2 | - | Alvin and the Chipmunks | $30,000,000 | $29,029,898 | -$970,102 | -3.2% | 3,484 | $142,375,000 | $141,404,467 | 3 | Twentieth Century Fox | - |
| 3 | 3 | - | I Am Legend | $27,500,000 | $27,414,467 | -$85,533 | -0.3% | 3,636 | $194,575,000 | $194,489,704 | 3 | Warner Bros. | - |
| 4 | 4 | - | Charlie Wilson's War | $11,768,000 | $12,012,360 | +$244,360 | +2.1% | 2,575 | $34,506,000 | $34,750,790 | 2 | Universal Pictures | - |
| 5 | 5 | - | Juno | $10,300,000 | $10,634,576 | +$334,576 | +3.2% | 1,019 | $25,681,000 | $26,015,794 | 4 | Fox Searchlight Pictures | - |
| 6 | 6 | - | Aliens vs. Predator: Requiem | $10,050,000 | $10,059,425 | +$9,425 | <0.1% | 2,611 | $26,880,000 | $26,889,442 | 1 | Twentieth Century Fox | - |
| 7 | 8 | +1 | The Water Horse | $9,200,000 | $9,186,054 | -$13,946 | -0.2% | 2,772 | $16,821,000 | $16,797,265 | 1 | Revolution Studios | - |
| 8 | 7 | -1 | P.S. I Love You | $9,100,000 | $9,289,337 | +$189,337 | +2.1% | 2,464 | $23,398,000 | $23,586,893 | 2 | Warner Bros. | - |
| 9 | 9 | - | Sweeney Todd: The Demon Barber of Fleet Street | $8,000,000 | $8,194,360 | +$194,360 | +2.4% | 1,249 | $26,719,000 | $26,913,596 | 2 | DreamWorks | - |
| 10 | 10 | - | Enchanted | $6,500,000 | $6,431,622 | -$68,378 | -1.1% | 2,262 | $110,650,000 | $110,580,392 | 6 | Walt Disney Studios Motion Pictures | - |
| 11 | 11 | - | The Great Debaters | $6,304,000 | $6,005,180 | -$298,820 | -4.7% | 1,171 | $13,548,000 | $13,256,188 | 1 | Metro-Goldwyn-Mayer (MGM) | - |
| 12 | 12 | - | The Golden Compass | $4,360,000 | - | - | - | 1,935 | $58,869,000 | - | 4 | New Line Cinema | - |
| 13 | 13 | - | Walk Hard: The Dewey Cox Story | $3,700,000 | $3,853,916 | +$153,916 | +4.2% | 2,650 | $12,252,000 | $12,423,244 | 2 | Sony Pictures Releasing | - |
| 14 | 14 | - | Atonement | $3,085,000 | $3,123,028 | +$38,028 | +1.2% | 310 | $11,199,000 | $11,237,143 | 4 | Focus Features | - |
| 15 | 15 | - | No Country for Old Men | $2,215,000 | - | - | - | 960 | $41,065,000 | - | 8 | Miramax | - |
| 16 | 16 | - | The Kite Runner | $1,844,000 | $1,845,396 | +$1,396 | <0.1% | 377 | $5,395,000 | $5,396,683 | 3 | Paramount Vantage | - |
| 17 | 19 | +2 | This Christmas | $520,000 | $393,150 | -$126,850 | -24.4% | 341 | $48,952,000 | $48,781,228 | 6 | Screen Gems | - |
| 18 | 18 | - | The Savages | $515,000 | $522,952 | +$7,952 | +1.5% | 111 | $1,683,000 | $1,690,511 | 5 | Fox Searchlight Pictures | - |
| 19 | 21 | +2 | The Bucket List | $323,000 | $335,837 | +$12,837 | +4% | 16 | $618,000 | $631,725 | 1 | Warner Bros. | - |
| 20 | 23 | +3 | American Gangster | $301,000 | $294,715 | -$6,285 | -2.1% | 307 | $129,025,000 | $129,018,725 | 9 | Universal Pictures | - |
| 21 | 25 | +4 | The Diving Bell and the Butterfly | $260,000 | $273,246 | +$13,246 | +5.1% | 44 | $870,000 | $882,696 | 5 | Miramax | - |
| 22 | 27 | +5 | The Orphanage | $230,000 | $233,323 | +$3,323 | +1.4% | 19 | $230,000 | $233,323 | 1 | Picturehouse | - |
| 23 | 32 | +9 | There Will Be Blood | $186,000 | $190,739 | +$4,739 | +2.5% | 2 | $310,000 | $314,917 | 1 | Paramount Vantage | - |
| 24 | 35 | +11 | Before the Devil Knows You're Dead | $128,000 | $133,870 | +$5,870 | +4.6% | 101 | $6,418,000 | $6,424,171 | 10 | THINKFilm | - |
| 25 | 37 | +12 | I'm Not There | $110,000 | $117,143 | +$7,143 | +6.5% | 93 | $3,080,000 | $3,087,475 | 6 | The Weinstein Company | - |
| 26 | 39 | +13 | Persepolis | $91,100 | $88,826 | -$2,274 | -2.5% | 7 | $167,000 | $163,372 | 1 | Sony Pictures Classics | - |
| 27 | 43 | +16 | Awake | $65,000 | $66,120 | +$1,120 | +1.7% | 88 | $14,074,000 | $14,055,487 | 5 | Metro-Goldwyn-Mayer (MGM) | - |
| 28 | 47 | +19 | Lars and the Real Girl | $43,000 | $43,192 | +$192 | +0.4% | 40 | $5,691,000 | $5,687,152 | 12 | Metro-Goldwyn-Mayer (MGM) | - |
| 29 | 50 | +21 | Youth Without Youth | $30,100 | $29,874 | -$226 | -0.8% | 18 | $129,000 | $128,979 | 3 | Sony Pictures Classics | - |
| 30 | 51 | +21 | Starting Out in the Evening | $29,100 | $29,653 | +$553 | +1.9% | 18 | $465,000 | $465,767 | 6 | Roadside Attractions | - |
| 31 | 53 | +22 | The Mist | $27,000 | $25,188 | -$1,812 | -6.7% | 71 | $25,301,000 | $25,296,735 | 6 | Metro-Goldwyn-Mayer (MGM) | - |
| 32 | 57 | +25 | Lust, Caution | $18,700 | $20,626 | +$1,926 | +10.3% | 19 | $4,515,000 | $4,523,146 | 14 | Focus Features | - |
| 33 | 58 | +25 | Steep | $16,800 | $16,105 | -$695 | -4.1% | 14 | $54,300 | $55,771 | 2 | Sony Pictures Classics | - |
| 34 | 54 | +20 | Bella | $12,500 | $24,044 | +$11,544 | +92.4% | 39 | $7,604,000 | $7,600,666 | 10 | Roadside Attractions | - |
| 35 | 63 | +28 | Control | $6,400 | $5,821 | -$579 | -9% | 12 | $833,000 | $832,504 | 12 | The Weinstein Company | - |
| 36 | 67 | +31 | Lions for Lambs | $3,000 | $2,847 | -$153 | -5.1% | 12 | $14,937,000 | $14,934,551 | 8 | United Artists | - |
| 37 | 71 | +34 | Blonde Ambition | $2,300 | $2,083 | -$217 | -9.4% | 8 | $4,900 | $4,658 | 2 | First Look International | - |
| 38 | 85 | +47 | Death at a Funeral | $1,000 | $552 | -$448 | -44.8% | 4 | $8,580,000 | $8,579,573 | 20 | Metro-Goldwyn-Mayer (MGM) | - |
