| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Enchanted | $3,293,426 | - | 404 | - | $8,152 | $3,301,356 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Winx Club: The Secret of the Lost Kingdom | $1,591,615 | -45.2% | 523 | -9 | $3,043 | $5,372,374 | 2 | 01 Distribution | false | false |
| 3 | 2 | Matrimonio alle Bahamas | $1,569,759 | -18.5% | 274 | -78 | $5,729 | $13,816,953 | 4 | Medusa Distribuzione | false | false |
| 4 | - | Hitman | $1,138,087 | - | 224 | - | $5,080 | $1,138,087 | 1 | 20th Century Fox International | true | false |
| 5 | 3 | Milan Palermo - The Return | $857,815 | -37.2% | 233 | -18 | $3,681 | $5,421,334 | 3 | Walt Disney Pictures | false | false |
| 6 | 4 | 1408 | $776,039 | -39.5% | 220 | -8 | $3,527 | $5,111,940 | 3 | Lucky Red | false | false |
| 7 | 5 | Lezioni di cioccolato | $740,945 | -11.2% | 212 | +1 | $3,495 | $3,137,242 | 3 | Universal Pictures International (UPI) | false | false |
| 8 | 6 | In the Valley of Elah | $560,675 | -18.1% | 180 | +11 | $3,114 | $1,474,683 | 2 | Mikado Film | false | false |
| 9 | 8 | August Rush | $470,558 | -21.6% | 190 | +1 | $2,476 | $1,333,150 | 2 | Medusa Distribuzione | false | false |
| 10 | 9 | The Heartbreak Kid | $367,299 | -34.9% | 103 | -32 | $3,566 | $8,456,227 | 5 | Universal Pictures International (UPI) | false | false |
| 11 | 7 | Come tu mi vuoi | $316,150 | -52.1% | 116 | -82 | $2,725 | $10,294,195 | 5 | Medusa Distribuzione | false | false |
| 12 | - | Paranoid Park | $260,698 | - | 69 | - | $3,778 | $260,698 | 1 | Lucky Red | true | false |
| 13 | 11 | The Kingdom | $232,738 | -38% | 99 | -3 | $2,350 | $764,966 | 2 | Universal Pictures International (UPI) | false | false |
| 14 | - | Irina Palm | $191,294 | - | 37 | - | $5,170 | $208,848 | 1 | Teodora Film | true | false |
| 15 | 10 | Beowulf | $174,632 | -59.1% | 85 | -67 | $2,054 | $4,974,542 | 4 | Warner Bros. | false | false |
| 16 | - | Days of Darkness | $144,714 | - | 34 | - | $4,256 | $144,714 | 1 | BIM Distribuzione | true | false |
| 17 | 12 | The Nanny Diaries | $133,288 | -58.2% | 105 | -16 | $1,269 | $545,345 | 2 | 01 Distribution | false | false |
| 18 | 16 | I Viceré | $126,498 | -8.7% | 70 | +28 | $1,807 | $2,205,747 | 5 | 01 Distribution | false | false |
| 19 | 14 | Ratatouille | $109,024 | -34.5% | 61 | -43 | $1,787 | $25,471,319 | 8 | Walt Disney Pictures | false | false |
| 20 | 15 | Across the Universe | $105,191 | -26.1% | 44 | -15 | $2,390 | $637,425 | 3 | Sony Pictures Releasing | false | false |
| 21 | 17 | Don't Waste Your Time, Johnny! | $96,174 | -29.9% | 56 | -8 | $1,717 | $299,385 | 2 | Medusa Distribuzione | false | false |
| 22 | 18 | Days and Clouds | $67,130 | -27.5% | 37 | +8 | $1,814 | $5,345,889 | 7 | Warner Bros. | false | false |
| 23 | 13 | Fred Claus | $57,358 | -69.4% | 69 | -24 | $831 | $288,393 | 2 | Warner Bros. | false | false |
| 24 | 20 | Conversations with My Gardener | $54,673 | -35.9% | 26 | -4 | $2,102 | $316,123 | 3 | BIM Distribuzione | false | false |
| 25 | 19 | Fracture | $49,495 | -44.6% | 22 | -3 | $2,249 | $3,396,075 | 6 | Eagle Pictures | false | false |
| 26 | 22 | The Hideout | $32,615 | -39.8% | 24 | -3 | $1,358 | $1,577,952 | 4 | 01 Distribution | false | false |
| 27 | 24 | Elizabeth: The Golden Age | $29,059 | -22% | 16 | -1 | $1,816 | $6,482,042 | 7 | Universal Pictures International (UPI) | false | false |
| 28 | 21 | The Edge of Heaven | $27,771 | -48.8% | 17 | -8 | $1,633 | $620,086 | 5 | BIM Distribuzione | false | false |
| 29 | - | The Tiger Brigades | $27,215 | - | 28 | - | $971 | $27,215 | 1 | Independent Films | true | false |
| 30 | 27 | The Nightmare Before Christmas 2008 3D Release | $22,147 | -19.2% | 6 | -1 | $3,691 | $62,211 | 2 | Walt Disney Pictures | false | false |
| 31 | 31 | Sleuth | $20,356 | +4.4% | 14 | +6 | $1,454 | $661,788 | 5 | Sony Pictures Releasing | false | false |
| 32 | 29 | Jellyfish | $19,993 | -16.7% | 12 | +4 | $1,666 | $197,313 | 4 | Sacher Distribuzione | false | false |
| 33 | 28 | The Right Distance | $18,532 | -24.2% | 13 | +6 | $1,425 | $1,298,505 | 8 | 01 Distribution | false | false |
| 34 | 26 | Factory Girl | $17,012 | -45.9% | 13 | -8 | $1,308 | $208,111 | 3 | Moviemax | false | false |
| 35 | 25 | The Bourne Ultimatum | $15,966 | -56.8% | 6 | -8 | $2,661 | $6,952,328 | 6 | Universal Pictures International (UPI) | false | false |
| 36 | 33 | Blade Runner The Final Cut (2007 re-release) | $9,768 | -38.6% | 5 | -1 | $1,953 | $41,382 | 2 | Warner Bros. | false | false |
| 37 | 35 | The Girl by the Lake | $8,396 | -35% | 5 | - | $1,679 | $3,702,878 | 13 | Medusa Distribuzione | false | false |
| 38 | 37 | L'abbuffata | $8,371 | -21.8% | 4 | -2 | $2,092 | $210,592 | 4 | Istituto Luce | false | false |
| 39 | 38 | Youth Without Youth | $6,448 | -36.1% | 7 | - | $921 | $905,200 | 7 | BIM Distribuzione | false | false |
| 40 | 30 | SMS - Sotto mentite spoglie | $6,290 | -70.3% | 5 | +1 | $1,258 | $7,733,366 | 9 | Medusa Distribuzione | false | false |
| 41 | 42 | Civico zero | $5,480 | +2.4% | 2 | +1 | $2,740 | $25,777 | 3 | Istituto Luce | false | false |
| 42 | 46 | Silk | $4,048 | +34.2% | 4 | -1 | $1,012 | $1,398,130 | 7 | Medusa Distribuzione | false | false |
| 43 | 23 | O Jerusalem | $3,062 | -93.8% | 4 | -12 | $765 | $208,544 | 3 | Medusa Distribuzione | false | false |
| 44 | 44 | The Wind Blows Round | $2,497 | -39.3% | 1 | -2 | $2,497 | $346,141 | 32 | Aranciafilm | false | false |
| 45 | - | It's a Free World... | $2,287 | - | 2 | - | $1,143 | $1,080,790 | 11 | BIM Distribuzione | false | false |
| 46 | - | Io non c'entro | $2,171 | - | 2 | - | $1,085 | $13,206 | 2 | Independent Films | false | false |
| 47 | - | Stardust | $2,003 | - | 3 | - | $667 | $3,233,911 | 9 | Universal Pictures International (UPI) | false | false |
| 48 | - | The Romance of Astrea and Celadon | $1,899 | - | 4 | - | $474 | $238,359 | 15 | BIM Distribuzione | false | false |
| 49 | - | 2061: Un anno eccezionale | $1,747 | - | 1 | - | $1,747 | $2,665,046 | 7 | 01 Distribution | false | false |
