| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | The Bourne Ultimatum | $70,181,000 | $69,283,690 | -$897,310 | -1.3% | 3,660 | $70,181,000 | $69,283,690 | 1 | Universal Pictures | - |
| 2 | 2 | - | The Simpsons Movie | $25,600,000 | $25,110,873 | -$489,127 | -1.9% | 3,926 | $128,550,000 | $128,060,578 | 2 | Twentieth Century Fox | - |
| 3 | 3 | - | Underdog | $12,009,000 | $11,585,121 | -$423,879 | -3.5% | 3,013 | $12,009,000 | $11,585,121 | 1 | Walt Disney Studios Motion Pictures | - |
| 4 | 4 | - | I Now Pronounce You Chuck & Larry | $10,528,000 | $10,626,345 | +$98,345 | +0.9% | 3,289 | $91,697,000 | $91,795,450 | 3 | Universal Pictures | - |
| 5 | 6 | +1 | Hairspray | $9,320,000 | $9,225,378 | -$94,622 | -1% | 3,115 | $78,949,000 | $78,854,798 | 3 | New Line Cinema | - |
| 6 | 5 | -1 | Harry Potter and the Order of the Phoenix | $9,290,000 | $9,522,220 | +$232,220 | +2.5% | 3,125 | $260,795,000 | $261,027,397 | 4 | Warner Bros. | - |
| 7 | 7 | - | No Reservations | $6,570,000 | $6,588,375 | +$18,375 | +0.3% | 2,425 | $24,157,000 | $24,175,203 | 2 | Warner Bros. | - |
| 8 | 8 | - | Transformers | $5,950,000 | $6,021,472 | +$71,472 | +1.2% | 2,419 | $296,308,000 | $296,379,328 | 5 | DreamWorks | - |
| 9 | 9 | - | Hot Rod | $5,015,000 | $5,310,711 | +$295,711 | +5.9% | 2,607 | $5,015,000 | $5,310,711 | 1 | Paramount Pictures | - |
| 10 | 10 | - | Bratz | $4,310,000 | $4,208,455 | -$101,545 | -2.4% | 1,509 | $4,310,000 | $4,208,455 | 1 | Lionsgate | - |
| 11 | 11 | - | Ratatouille | $4,024,000 | $3,987,800 | -$36,200 | -0.9% | 1,940 | $188,282,000 | $188,246,213 | 6 | Walt Disney Studios Motion Pictures | - |
| 12 | 12 | - | El cantante | $3,254,000 | $3,202,035 | -$51,965 | -1.6% | 542 | $3,254,000 | $3,202,035 | 1 | Picturehouse | - |
| 13 | 13 | - | Live Free or Die Hard | $2,200,000 | $2,132,768 | -$67,232 | -3.1% | 1,422 | $130,246,000 | $130,178,275 | 6 | Twentieth Century Fox | - |
| 14 | 14 | - | I Know Who Killed Me | $1,150,000 | $1,165,378 | +$15,378 | +1.3% | 1,320 | $6,216,000 | $6,231,700 | 2 | Sony Pictures Releasing | - |
| 15 | 15 | - | Who's Your Caddy? | $1,100,000 | $1,092,324 | -$7,676 | -0.7% | 962 | $4,811,000 | $4,803,661 | 2 | Metro-Goldwyn-Mayer (MGM) | - |
| 16 | 16 | - | Becoming Jane | $1,010,000 | $972,066 | -$37,934 | -3.8% | 100 | $1,010,000 | $972,066 | 1 | Miramax | - |
| 17 | 17 | - | Talk to Me | $681,000 | $674,089 | -$6,911 | -1% | 187 | $2,847,000 | $2,840,675 | 4 | Focus Features | - |
| 18 | 18 | - | Rescue Dawn | $550,000 | $560,903 | +$10,903 | +2% | 505 | $4,208,000 | $4,218,459 | 5 | Metro-Goldwyn-Mayer (MGM) | - |
| 19 | 19 | - | Knocked Up | $523,000 | $503,730 | -$19,270 | -3.7% | 392 | $146,304,000 | $146,284,175 | 10 | Universal Pictures | - |
| 20 | 20 | - | Sicko | $510,000 | $503,702 | -$6,298 | -1.2% | 349 | $22,647,000 | $22,640,294 | 7 | Lionsgate | - |
| 21 | 22 | +1 | Sunshine | $450,000 | $448,386 | -$1,614 | -0.4% | 383 | $2,685,000 | $2,683,625 | 3 | Fox Searchlight Pictures | - |
| 22 | 23 | +1 | Evan Almighty | $382,000 | $374,105 | -$7,895 | -2.1% | 376 | $97,386,000 | $97,378,830 | 7 | Universal Pictures | - |
| 23 | 25 | +2 | Once | $300,000 | $284,084 | -$15,916 | -5.3% | 140 | $6,545,000 | $6,529,474 | 12 | Fox Searchlight Pictures | - |
| 24 | 29 | +5 | La Vie En Rose | $222,000 | $221,623 | -$377 | -0.2% | 125 | $8,662,000 | $8,662,108 | 9 | Picturehouse | - |
| 25 | 34 | +9 | My Best Friend | $161,000 | $143,738 | -$17,262 | -10.7% | 63 | $638,000 | $620,420 | 4 | IFC Films | - |
| 26 | 37 | +11 | The Ten | $117,500 | $121,374 | +$3,874 | +3.3% | 25 | $117,500 | $121,374 | 1 | THINKFilm | - |
| 27 | 42 | +15 | Paris, Je T'aime | $63,300 | $62,189 | -$1,111 | -1.8% | 40 | $4,859,000 | $4,857,374 | 14 | First Look International | - |
| 28 | 44 | +16 | The Call of Wild | $53,400 | $51,643 | -$1,757 | -3.3% | 28 | $95,800 | $93,972 | 2 | Paramount Vantage | - |
| 29 | 53 | +24 | You Kill Me | $42,300 | $24,267 | -$18,033 | -42.6% | 26 | $2,403,000 | $2,385,146 | 7 | IFC Films | - |
| 30 | 56 | +26 | This Is England | $19,700 | $19,000 | -$700 | -3.6% | 2 | $49,800 | $49,151 | 2 | IFC Films | - |
