| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | The Simpsons Movie | $71,850,000 | $74,036,787 | +$2,186,787 | +3% | 3,922 | $71,850,000 | $74,036,787 | 1 | Twentieth Century Fox | - |
| 2 | 2 | - | I Now Pronounce You Chuck & Larry | $19,063,000 | $19,132,965 | +$69,965 | +0.4% | 3,501 | $71,610,000 | $71,680,080 | 2 | Universal Pictures | - |
| 3 | 3 | - | Harry Potter and the Order of the Phoenix | $17,065,000 | $17,733,085 | +$668,085 | +3.9% | 4,005 | $241,771,000 | $242,439,214 | 3 | Warner Bros. | - |
| 4 | 4 | - | Hairspray | $15,550,000 | - | - | - | 3,121 | $59,307,000 | - | 2 | New Line Cinema | - |
| 5 | 5 | - | No Reservations | $11,755,000 | $11,704,357 | -$50,643 | -0.4% | 2,425 | $11,755,000 | $11,704,357 | 1 | Warner Bros. | - |
| 6 | 6 | - | Transformers | $11,524,000 | $11,643,129 | +$119,129 | +1% | 3,349 | $284,558,000 | $284,677,134 | 4 | DreamWorks | - |
| 7 | 7 | - | Ratatouille | $7,234,000 | $7,455,594 | +$221,594 | +3.1% | 2,934 | $179,683,000 | $179,904,396 | 5 | Walt Disney Studios Motion Pictures | - |
| 8 | 8 | - | Live Free or Die Hard | $5,350,000 | $5,618,728 | +$268,728 | +5% | 2,271 | $125,128,000 | $125,396,389 | 5 | Twentieth Century Fox | - |
| 9 | 9 | - | I Know Who Killed Me | $3,400,000 | $3,506,291 | +$106,291 | +3.1% | 1,320 | $3,400,000 | $3,506,291 | 1 | Sony Pictures Releasing | - |
| 10 | 10 | - | Who's Your Caddy? | $2,900,000 | $2,756,661 | -$143,339 | -4.9% | 1,019 | $2,900,000 | $2,756,661 | 1 | Metro-Goldwyn-Mayer (MGM) | - |
| 11 | 11 | - | Rescue Dawn | $1,652,000 | $1,650,282 | -$1,718 | -0.1% | 500 | $2,956,000 | $2,954,746 | 4 | Metro-Goldwyn-Mayer (MGM) | - |
| 12 | 12 | - | License to Wed | $1,280,000 | $1,287,411 | +$7,411 | +0.6% | 1,610 | $41,700,000 | $41,707,459 | 4 | Warner Bros. | - |
| 13 | 13 | - | Sunshine | $1,265,000 | $1,262,996 | -$2,004 | -0.2% | 461 | $1,628,000 | $1,625,497 | 2 | Fox Searchlight Pictures | - |
| 14 | 17 | +3 | 1408 | $1,213,000 | $1,139,669 | -$73,331 | -6% | 981 | $70,000,000 | $69,926,874 | 6 | Metro-Goldwyn-Mayer (MGM) | - |
| 15 | 14 | -1 | Knocked Up | $1,196,000 | $1,227,605 | +$31,605 | +2.6% | 792 | $145,131,000 | $145,162,955 | 9 | Universal Pictures | - |
| 16 | 15 | -1 | Sicko | $1,180,000 | $1,173,740 | -$6,260 | -0.5% | 850 | $21,500,000 | $21,493,605 | 6 | Lionsgate | - |
| 17 | 16 | -1 | Evan Almighty | $1,096,000 | $1,146,335 | +$50,335 | +4.6% | 1,010 | $96,283,000 | $96,333,065 | 6 | Universal Pictures | - |
| 18 | 18 | - | Talk to Me | $803,000 | - | - | - | 115 | $1,886,000 | - | 3 | Focus Features | - |
| 19 | 23 | +4 | La Vie En Rose | $359,000 | $380,339 | +$21,339 | +5.9% | 161 | $8,218,000 | $8,239,183 | 8 | Picturehouse | - |
| 20 | 24 | +4 | Once | $340,000 | $341,716 | +$1,716 | +0.5% | 131 | $6,058,000 | $6,059,946 | 11 | Fox Searchlight Pictures | - |
| 21 | 32 | +11 | Evening | $127,000 | $125,743 | -$1,257 | -1% | 164 | $12,408,000 | $12,406,646 | 5 | Focus Features | - |
| 22 | 33 | +11 | Waitress | $120,000 | $118,262 | -$1,738 | -1.4% | 125 | $18,449,000 | $18,446,685 | 13 | Fox Searchlight Pictures | - |
| 23 | 35 | +12 | Goya's Ghosts | $110,000 | $112,083 | +$2,083 | +1.9% | 43 | $350,000 | $352,184 | 2 | The Samuel Goldwyn Company | - |
| 24 | 42 | +18 | Paris, Je T'aime | $70,700 | $70,261 | -$439 | -0.6% | 55 | $4,744,000 | $4,743,381 | 13 | First Look International | - |
| 25 | 48 | +23 | Interview | $41,800 | $40,446 | -$1,354 | -3.2% | 19 | $194,000 | $192,822 | 3 | Sony Pictures Classics | - |
| 26 | 49 | +23 | Molière | $32,900 | $32,601 | -$299 | -0.9% | 6 | $32,900 | $32,601 | 1 | Sony Pictures Classics | - |
| 27 | 50 | +23 | No End in Sight | $32,000 | $31,533 | -$467 | -1.5% | 2 | $32,000 | $31,533 | 1 | Magnolia Pictures | - |
| 28 | 55 | +27 | The Call of Wild | $20,600 | $22,607 | +$2,007 | +9.7% | 4 | $26,900 | $28,937 | 1 | Paramount Vantage | - |
