| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | 300 | $628,082 | - | 39 | - | $16,104 | $697,894 | 1 | Warner Bros. | true | false |
| 2 | - | Norbit | $374,754 | - | 33 | - | $11,356 | $453,131 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | - | Hunting and Gathering | $131,028 | - | 13 | - | $10,079 | $131,028 | 1 | Alternative Films | true | false |
| 4 | 1 | Night at the Museum | $110,432 | -44.5% | 71 | -5 | $1,555 | $3,301,915 | 6 | 20th Century Fox International | false | false |
| 5 | - | Breaking and Entering | $92,970 | - | 20 | - | $4,648 | $115,028 | 1 | Buena Vista International | true | false |
| 6 | 2 | Apocalypto | $91,765 | -47.5% | 39 | -14 | $2,352 | $594,743 | 3 | AF-Media | false | false |
| 7 | 3 | Firmin | $82,976 | -39.8% | 23 | -2 | $3,607 | $1,597,636 | 6 | N/A | false | false |
| 8 | 4 | The Number 23 | $72,201 | -38.9% | 23 | - | $3,139 | $647,728 | 4 | Paradiso Entertainment | false | false |
| 9 | - | With Friends Like These | $67,934 | - | 14 | - | $4,852 | $79,558 | 1 | Kinepolis Film Distribution (KFD) | true | false |
| 10 | 6 | La Vie En Rose | $63,494 | -36.7% | 25 | - | $2,539 | $1,327,253 | 6 | Cinéart | false | false |
| 11 | 5 | Taxi 4 | $52,984 | -51.4% | 35 | -7 | $1,513 | $2,419,374 | 6 | Belga Films | false | false |
| 12 | 10 | The Lives of Others | $52,334 | -18% | 14 | +1 | $3,738 | $741,699 | 8 | ABC Distribution | false | false |
| 13 | 7 | Freedom Writers | $46,339 | -47.6% | 13 | -2 | $3,564 | $152,381 | 2 | Universal Pictures International (UPI) | false | false |
| 14 | 9 | Barnyard | $39,677 | -40% | 31 | - | $1,279 | $551,943 | 5 | Universal Pictures International (UPI) | false | false |
| 15 | 8 | Ghost Rider | $37,291 | -53.2% | 28 | -2 | $1,331 | $893,481 | 5 | Sony Pictures Releasing | false | false |
| 16 | 15 | Crank | $36,329 | -34.8% | 10 | +1 | $3,632 | $101,434 | 2 | Paradiso Entertainment | false | false |
| 17 | 14 | Dance with Him | $34,940 | -37.6% | 11 | - | $3,176 | $167,054 | 3 | Victory Productions | false | false |
| 18 | 12 | Charlotte's Web | $33,939 | -43.3% | 54 | -4 | $628 | $1,076,209 | 7 | Universal Pictures International (UPI) | false | false |
| 19 | 13 | The Departed | $33,429 | -40.6% | 10 | -8 | $3,342 | $3,596,866 | 13 | Warner Bros. | false | false |
| 20 | 16 | Man of the Year | $25,164 | -53.9% | 11 | - | $2,287 | $98,814 | 2 | Benelux Film Distributors | false | false |
