| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Hannibal Rising | $1,716,848 | - | 325 | - | $5,282 | $1,716,848 | 1 | - | true | false |
| 2 | - | Norbit | $1,239,824 | - | 248 | - | $4,999 | $1,239,824 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 1 | Epic Movie | $1,086,092 | -38.4% | 300 | +2 | $3,620 | $3,121,183 | 2 | 20th Century Fox International | false | false |
| 4 | 3 | The Painted Veil | $688,329 | -19.1% | 205 | - | $3,357 | $1,854,303 | 2 | - | false | false |
| 5 | 2 | Bridge to Terabithia | $661,074 | -40.6% | 305 | - | $2,167 | $3,970,508 | 3 | DeAPlaneta | false | false |
| 6 | - | Lola, la película | $586,271 | - | 326 | - | $1,798 | $586,271 | 1 | DeAPlaneta | true | false |
| 7 | 5 | The Lives of Others | $406,864 | -9.6% | 98 | +1 | $4,151 | $2,724,825 | 5 | Alta Films | false | false |
| 8 | 4 | Blood Diamond | $388,185 | -25.8% | 264 | -52 | $1,470 | $8,473,589 | 6 | Warner Bros. | false | false |
| 9 | - | Goal II: Living the Dream | $275,554 | - | 103 | - | $2,675 | $275,554 | 1 | Buena Vista International | true | false |
| 10 | 11 | The Last King of Scotland | $205,997 | -25.7% | 107 | -3 | $1,925 | $1,825,388 | 4 | 20th Century Fox International | false | false |
| 11 | 6 | Ghost Rider | $193,049 | -51.8% | 224 | -106 | $861 | $7,348,531 | 5 | Sony Pictures Releasing | false | false |
| 12 | 10 | The Pursuit of Happyness | $179,265 | -40.2% | 184 | -73 | $974 | $8,621,163 | 7 | Sony Pictures Releasing | false | false |
| 13 | 8 | Bordertown | $165,528 | -48% | 168 | -82 | $985 | $2,599,152 | 4 | TriPictures | false | false |
| 14 | 9 | Theresa: The Body of Christ | $164,458 | -45.9% | 100 | - | $1,644 | $582,893 | 2 | Azteca Films | false | false |
| 15 | 16 | The Good German | $158,322 | -26.4% | 71 | +1 | $2,229 | $913,564 | 3 | Warner Bros. | false | false |
| 16 | 15 | The Departed | $157,694 | -29.6% | 97 | -27 | $1,625 | $13,491,819 | 21 | Warner Bros. | false | false |
| 17 | 14 | Night at the Museum | $149,070 | -38.8% | 184 | -70 | $810 | $16,659,393 | 8 | 20th Century Fox International | false | false |
| 18 | - | The Contestant | $126,201 | - | 94 | - | $1,342 | $126,201 | 1 | Filmax | true | false |
| 19 | 7 | Captivity | $99,130 | -69.4% | 184 | -12 | $538 | $503,764 | 2 | New World Pictures | false | false |
| 20 | 13 | The Host | $92,442 | -63.5% | 133 | -35 | $695 | $1,046,578 | 3 | Notro Films | false | false |
