| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Borat | $3,032,917 | - | 407 | - | $7,451 | $3,032,917 | 1 | 20th Century Fox International | true | false |
| 2 | 2 | Saturn in Opposition | $1,708,147 | -43.7% | 399 | +20 | $4,281 | $5,944,644 | 2 | Medusa Distribuzione | false | false |
| 3 | 1 | Notte prima degli esami - Oggi | $1,173,861 | -62.1% | 391 | -198 | $3,002 | $14,517,043 | 3 | 01 Distribution | false | false |
| 4 | 3 | Music and Lyrics | $962,162 | -42.4% | 326 | +1 | $2,951 | $3,141,904 | 2 | Warner Bros. | false | false |
| 5 | 4 | Night at the Museum | $475,621 | -57.3% | 195 | -68 | $2,439 | $14,385,586 | 5 | 20th Century Fox International | false | false |
| 6 | 5 | Alpha Dog | $473,048 | -44.7% | 190 | +5 | $2,489 | $1,651,955 | 2 | Moviemax | false | false |
| 7 | - | One Out of Two | $406,843 | - | 176 | - | $2,311 | $406,843 | 1 | 01 Distribution | true | false |
| 8 | 6 | Hannibal Rising | $264,368 | -64.8% | 131 | -97 | $2,018 | $7,392,170 | 4 | Filmauro | false | false |
| 9 | 7 | The Holiday | $245,742 | -61.1% | 133 | -91 | $1,847 | $5,529,869 | 4 | Universal Pictures International (UPI) | false | false |
| 10 | 8 | Notes on a Scandal | $244,237 | -42.2% | 93 | -1 | $2,626 | $838,065 | 2 | 20th Century Fox International | false | false |
| 11 | - | The Departed | $215,046 | - | 123 | - | $1,748 | $12,059,061 | 19 | Medusa Distribuzione | false | false |
| 12 | - | The Good German | $214,177 | - | 79 | - | $2,711 | $214,177 | 1 | Warner Bros. | true | false |
| 13 | 9 | Barnyard | $194,195 | -51.8% | 150 | - | $1,294 | $663,424 | 2 | Universal Pictures International (UPI) | false | false |
| 14 | 10 | Arthur and the Invisibles | $113,331 | -59% | 142 | -34 | $798 | $2,236,465 | 4 | 01 Distribution | false | false |
| 15 | 13 | The Painted Veil | $101,831 | -32.6% | 59 | -6 | $1,725 | $322,302 | 2 | Eagle Pictures | false | false |
| 16 | 17 | The Last King of Scotland | $89,755 | -14.7% | 47 | -1 | $1,909 | $509,472 | 3 | 20th Century Fox International | false | false |
| 17 | 11 | Letters from Iwo Jima | $89,040 | -51.7% | 40 | -15 | $2,226 | $645,252 | 3 | Warner Bros. | false | false |
| 18 | 12 | Blood Diamond | $49,188 | -67.7% | 41 | -30 | $1,199 | $5,538,210 | 6 | Warner Bros. | false | false |
| 19 | 14 | A Dinner for Them to Meet | $47,358 | -64% | 38 | -36 | $1,246 | $3,882,314 | 5 | Medusa Distribuzione | false | false |
| 20 | 15 | The Pursuit of Happyness | $42,515 | -67.3% | 23 | -41 | $1,848 | $20,205,370 | 8 | Medusa Distribuzione | false | false |
