| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Ghost Rider | $44,500,000 | $45,388,836 | +$888,836 | +2% | 3,619 | $44,500,000 | $45,388,836 | 1 | Sony Pictures Releasing | - |
| 2 | 2 | - | Bridge to Terabithia | $22,075,000 | $22,564,612 | +$489,612 | +2.2% | 3,139 | $22,075,000 | $22,564,612 | 1 | Walt Disney Studios Motion Pictures | - |
| 3 | 3 | - | Norbit | $16,802,000 | $16,775,831 | -$26,169 | -0.2% | 3,138 | $58,884,000 | $58,858,009 | 2 | DreamWorks | - |
| 4 | 4 | - | Music and Lyrics | $14,000,000 | $13,623,630 | -$376,370 | -2.7% | 2,955 | $19,529,000 | $19,152,249 | 1 | Warner Bros. | - |
| 5 | 5 | - | Daddy's Little Girls | $12,100,000 | $11,210,754 | -$889,246 | -7.3% | 2,111 | $17,793,000 | $16,904,003 | 1 | Lionsgate | - |
| 6 | 6 | - | Breach | $10,371,000 | $10,504,990 | +$133,990 | +1.3% | 1,489 | $10,371,000 | $10,504,990 | 1 | Universal Pictures | - |
| 7 | 7 | - | Hannibal Rising | $5,465,000 | $5,418,106 | -$46,894 | -0.9% | 3,003 | $22,127,000 | $22,080,446 | 2 | - | - |
| 8 | 8 | - | Because I Said So | $4,990,000 | $5,099,910 | +$109,910 | +2.2% | 2,446 | $33,248,000 | $33,357,575 | 3 | Universal Pictures | - |
| 9 | 9 | - | The Messengers | $3,800,000 | $3,763,570 | -$36,430 | -1% | 2,183 | $30,509,000 | $30,472,075 | 3 | Screen Gems | - |
| 10 | 10 | - | Night at the Museum | $3,700,000 | $3,704,724 | +$4,724 | +0.1% | 2,042 | $237,333,000 | $237,338,322 | 9 | Twentieth Century Fox | - |
| 11 | 11 | - | Pan's Labyrinth | $2,155,000 | $2,214,586 | +$59,586 | +2.8% | 905 | $30,001,000 | $30,061,211 | 8 | Picturehouse | - |
| 12 | 13 | +1 | Smokin' Aces | $1,428,000 | $1,488,895 | +$60,895 | +4.3% | 1,107 | $34,079,000 | $34,139,651 | 4 | Universal Pictures | - |
| 13 | 15 | +2 | The Queen | $1,258,000 | - | - | - | 807 | $51,000,000 | - | 21 | Miramax | - |
| 14 | 12 | -2 | Dreamgirls | $1,178,000 | $1,591,017 | +$413,017 | +35.1% | 1,037 | $99,222,000 | $99,634,994 | 10 | DreamWorks | - |
| 15 | 16 | +1 | Letters from Iwo Jima | $955,000 | $1,022,590 | +$67,590 | +7.1% | 651 | $11,494,000 | $11,561,827 | 9 | Warner Bros. | - |
| 16 | 18 | +2 | Notes on a Scandal | $840,000 | $851,430 | +$11,430 | +1.4% | 413 | $15,236,000 | $15,248,330 | 8 | - | - |
| 17 | 17 | - | The Last King of Scotland | $835,000 | $884,895 | +$49,895 | +6% | 384 | $12,706,000 | $12,756,249 | 21 | - | - |
| 18 | 21 | +3 | Babel | $583,000 | $589,971 | +$6,971 | +1.2% | 305 | $33,095,000 | $33,102,076 | 17 | Paramount Vantage | - |
| 19 | 23 | +4 | Factory Girl | $506,000 | $516,190 | +$10,190 | +2% | 336 | $899,000 | $909,138 | 8 | - | - |
| 20 | 27 | +7 | Children of Men | $426,000 | $364,350 | -$61,650 | -14.5% | 210 | $34,600,000 | $34,538,503 | 8 | Universal Pictures | - |
| 21 | 24 | +3 | Blood Diamond | $405,000 | $385,811 | -$19,189 | -4.7% | 225 | $55,797,000 | $55,778,161 | 11 | Warner Bros. | - |
| 22 | 25 | +3 | Volver | $403,000 | $375,264 | -$27,736 | -6.9% | 195 | $11,542,000 | $11,514,374 | 16 | Sony Pictures Classics | - |
| 23 | 28 | +5 | The Lives of Others | $366,000 | $350,878 | -$15,122 | -4.1% | 32 | $677,000 | $661,685 | 2 | Sony Pictures Classics | - |
| 24 | 26 | +2 | Venus | $356,000 | $374,272 | +$18,272 | +5.1% | 157 | $2,339,000 | $2,358,046 | 9 | Miramax | - |
| 25 | 29 | +4 | The Departed | $350,000 | $347,060 | -$2,940 | -0.8% | 320 | $131,441,000 | $131,438,233 | 20 | Warner Bros. | - |
| 26 | 33 | +7 | Happy Feet | $295,000 | $289,956 | -$5,044 | -1.7% | 305 | $193,806,000 | $193,800,551 | 14 | Warner Bros. | - |
| 27 | 34 | +7 | Charlotte's Web | $233,000 | $235,608 | +$2,608 | +1.1% | 350 | $81,334,000 | $81,336,628 | 10 | Paramount Pictures | - |
| 28 | 41 | +13 | Freedom Writers | $149,000 | $145,729 | -$3,271 | -2.2% | 232 | $36,239,000 | $36,235,753 | 7 | Paramount Pictures | - |
| 29 | 51 | +22 | The Good Shepherd | $55,000 | $45,210 | -$9,790 | -17.8% | 80 | $59,841,000 | $59,831,045 | 9 | Universal Pictures | - |
| 30 | 52 | +22 | Perfume: The Story of a Murderer | $42,000 | $38,297 | -$3,703 | -8.8% | 26 | $2,169,000 | $2,165,741 | 8 | DreamWorks | - |
| 31 | 53 | +22 | Alpha Dog | $41,000 | $36,565 | -$4,435 | -10.8% | 69 | $15,227,000 | $15,222,770 | 6 | Universal Pictures | - |
| 32 | 56 | +24 | Orchestra Seats | $30,500 | $29,377 | -$1,123 | -3.7% | 2 | $30,500 | $29,377 | 1 | THINKFilm | - |
