| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Night at the Museum | $499,588 | - | 100 | - | $4,995 | $527,099 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Blood Diamond | $227,734 | -34.8% | 80 | +1 | $2,846 | $2,415,096 | 4 | Warner Bros. | false | false |
| 3 | - | The Good Shepherd | $165,808 | - | 58 | - | $2,858 | $172,382 | 1 | Benelux Film Distributors | true | false |
| 4 | 2 | The Pursuit of Happyness | $143,142 | -38% | 33 | - | $4,337 | $829,450 | 3 | Sony Pictures Releasing | false | false |
| 5 | 3 | The Prestige | $132,547 | -31.8% | 30 | - | $4,418 | $403,357 | 2 | Warner Bros. | false | false |
| 6 | - | Ernst, Bobbie en de geslepen Onix | $122,970 | - | 107 | - | $1,149 | $183,107 | 1 | Independent Films | true | false |
| 7 | - | Barnyard | $83,926 | - | 72 | - | $1,165 | $113,936 | 1 | Universal Pictures International (UPI) | true | false |
| 8 | 4 | Smokin' Aces | $70,395 | -51.2% | 40 | - | $1,759 | $578,113 | 3 | Universal Pictures International (UPI) | false | false |
| 9 | 5 | Casino Royale | $64,011 | -45.8% | 70 | -20 | $914 | $10,414,082 | 13 | Sony Pictures Releasing | false | false |
| 10 | 10 | The Last King of Scotland | $60,944 | <0.1% | 15 | - | $4,062 | $150,208 | 2 | 20th Century Fox International | false | false |
| 11 | 19 | The Queen | $55,232 | +40.6% | 23 | -1 | $2,401 | $1,059,736 | 12 | A-Film Distribution | false | false |
| 12 | 9 | Babel | $52,046 | -25.3% | 32 | -4 | $1,626 | $1,907,901 | 16 | Independent Films | false | false |
| 13 | 6 | Arthur and the Invisibles | $44,502 | -57.9% | 86 | - | $517 | $325,952 | 3 | Independent Films | false | false |
| 14 | 7 | Happy Feet | $35,563 | -64.5% | 99 | -21 | $359 | $6,908,705 | 11 | Warner Bros. | false | false |
| 15 | 18 | Perfume: The Story of a Murderer | $31,076 | -21.7% | 28 | -11 | $1,109 | $1,743,404 | 11 | RCV Film Distribution | false | false |
| 16 | 16 | Little Children | $30,298 | -25.3% | 16 | -1 | $1,893 | $259,400 | 4 | A-Film Distribution | false | false |
| 17 | 8 | The Holiday | $29,733 | -59.2% | 52 | -28 | $571 | $4,721,119 | 10 | United International Pictures | false | false |
| 18 | 11 | Miss Potter | $28,986 | -48.3% | 50 | -1 | $579 | $147,130 | 2 | RCV Film Distribution | false | false |
| 19 | 20 | Black Book | $26,521 | -27.8% | 40 | -6 | $663 | $9,734,514 | 23 | A-Film Distribution | false | false |
| 20 | - | Letters from Iwo Jima | $22,590 | - | 20 | - | $1,129 | $22,590 | 1 | Warner Bros. | true | false |
