| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Notte prima degli esami - Oggi | $5,995,980 | - | 604 | - | $9,927 | $7,615,046 | 1 | 01 Distribution | true | false |
| 2 | 1 | Night at the Museum | $1,715,948 | -46.2% | 364 | -99 | $4,714 | $12,099,205 | 3 | 20th Century Fox International | false | false |
| 3 | 2 | Hannibal Rising | $1,556,857 | -45.5% | 358 | -7 | $4,348 | $5,538,909 | 2 | Filmauro | false | false |
| 4 | 3 | The Holiday | $1,263,272 | -36.5% | 319 | +3 | $3,960 | $3,984,339 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | Manual of Love 2 | $536,864 | -54.7% | 186 | +159 | $2,886 | $24,514,778 | 5 | Filmauro | false | false |
| 6 | 6 | Arthur and the Invisibles | $507,543 | -45.4% | 320 | -25 | $1,586 | $1,661,314 | 2 | 01 Distribution | false | false |
| 7 | 5 | A Dinner for Them to Meet | $479,896 | -49.1% | 205 | -55 | $2,340 | $3,545,555 | 3 | Medusa Distribuzione | false | false |
| 8 | 7 | The Pursuit of Happyness | $376,887 | -48.2% | 138 | -60 | $2,731 | $19,787,731 | 6 | Medusa Distribuzione | false | false |
| 9 | 8 | Blood Diamond | $372,407 | -41.7% | 135 | -48 | $2,758 | $5,159,921 | 4 | Warner Bros. | false | false |
| 10 | 10 | Mi fido di te | $236,230 | -21.9% | 110 | +7 | $2,147 | $659,136 | 2 | Medusa Distribuzione | false | false |
| 11 | - | Letters from Iwo Jima | $212,740 | - | 47 | - | $4,526 | $212,740 | 1 | Warner Bros. | true | false |
| 12 | 9 | Step Up | $198,762 | -62% | 101 | -76 | $1,967 | $4,743,789 | 4 | Medusa Distribuzione | false | false |
| 13 | - | The Last King of Scotland | $172,915 | - | 49 | - | $3,528 | $172,915 | 1 | 20th Century Fox International | true | false |
| 14 | - | The Covenant | $112,936 | - | 52 | - | $2,171 | $112,936 | 1 | Sony Pictures Releasing | true | false |
| 15 | 15 | The Page Turner | $87,961 | +21.6% | 29 | +13 | $3,033 | $194,608 | 2 | Mikado Film | false | false |
| 16 | 13 | Bobby | $81,850 | -30.8% | 33 | - | $2,480 | $1,752,241 | 5 | 01 Distribution | false | false |
| 17 | 14 | Inland Empire | $75,636 | -29.5% | 26 | +2 | $2,909 | $245,799 | 2 | BIM Distribuzione | false | false |
| 18 | 11 | Breaking and Entering | $59,182 | -58.9% | 59 | -18 | $1,003 | $260,381 | 2 | Buena Vista International | false | false |
| 19 | 12 | Miss Potter | $57,563 | -55.6% | 21 | -33 | $2,741 | $603,999 | 3 | Eagle Pictures | false | false |
| 20 | 16 | The Science of Sleep | $34,365 | -44.1% | 14 | -12 | $2,454 | $760,566 | 5 | Mikado Film | false | false |
