| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Norbit | $33,740,000 | $34,195,434 | +$455,434 | +1.3% | 3,136 | $33,740,000 | $34,195,434 | 1 | DreamWorks | - |
| 2 | 2 | - | Hannibal Rising | $13,350,000 | $13,051,650 | -$298,350 | -2.2% | 3,003 | $13,350,000 | $13,051,650 | 1 | Metro-Goldwyn-Mayer (MGM) | - |
| 3 | 3 | - | Because I Said So | $9,041,000 | $9,221,130 | +$180,130 | +2% | 2,529 | $25,626,000 | $25,805,720 | 2 | Universal Pictures | - |
| 4 | 4 | - | The Messengers | $7,200,000 | $7,218,187 | +$18,187 | +0.3% | 2,529 | $24,724,000 | $24,742,205 | 2 | Screen Gems | - |
| 5 | 5 | - | Night at the Museum | $5,750,000 | $5,754,359 | +$4,359 | <0.1% | 2,702 | $232,146,000 | $232,150,355 | 8 | Twentieth Century Fox | - |
| 6 | 6 | - | Epic Movie | $4,450,000 | $4,570,090 | +$120,090 | +2.7% | 2,806 | $35,474,000 | $35,594,259 | 3 | Twentieth Century Fox | - |
| 7 | 7 | - | Smokin' Aces | $3,793,000 | $4,113,020 | +$320,020 | +8.4% | 2,199 | $30,854,000 | $31,174,140 | 3 | Universal Pictures | - |
| 8 | 8 | - | Pan's Labyrinth | $3,549,000 | $3,577,283 | +$28,283 | +0.8% | 1,143 | $26,591,000 | $26,619,057 | 7 | Picturehouse | - |
| 9 | 9 | - | Dreamgirls | $3,093,000 | $2,980,967 | -$112,033 | -3.6% | 2,284 | $97,119,000 | $97,006,872 | 9 | DreamWorks | - |
| 10 | 10 | - | The Queen | $2,510,000 | - | - | - | 1,564 | $49,035,000 | - | 20 | Miramax | - |
| 11 | 11 | - | Stomp the Yard | $2,400,000 | $2,358,159 | -$41,841 | -1.7% | 2,045 | $59,123,000 | $59,080,670 | 5 | Screen Gems | - |
| 12 | 12 | - | The Pursuit of Happyness | $2,400,000 | $2,353,543 | -$46,457 | -1.9% | 1,777 | $160,537,000 | $160,490,618 | 9 | Sony Pictures Releasing | - |
| 13 | 13 | - | Catch and Release | $1,800,000 | $1,760,183 | -$39,817 | -2.2% | 1,561 | $14,447,000 | $14,406,807 | 3 | Sony Pictures Releasing | - |
| 14 | 15 | +1 | Babel | $1,751,000 | $1,677,367 | -$73,633 | -4.2% | 919 | $32,093,000 | $32,019,555 | 16 | Paramount Vantage | - |
| 15 | 14 | -1 | Letters from Iwo Jima | $1,665,000 | $1,729,451 | +$64,451 | +3.9% | 781 | $9,870,000 | $9,935,921 | 8 | Warner Bros. | - |
| 16 | 16 | - | Notes on a Scandal | $1,575,000 | $1,542,843 | -$32,157 | -2% | 649 | $13,958,000 | $13,926,668 | 7 | Fox Searchlight Pictures | - |
| 17 | 18 | +1 | The Last King of Scotland | $1,350,000 | $1,340,740 | -$9,260 | -0.7% | 540 | $11,458,000 | $11,449,370 | 20 | Fox Searchlight Pictures | - |
| 18 | 17 | -1 | The Departed | $1,345,000 | $1,342,338 | -$2,662 | -0.2% | 766 | $130,748,000 | $130,744,874 | 19 | Warner Bros. | - |
| 19 | 19 | - | Freedom Writers | $1,032,000 | $1,018,435 | -$13,565 | -1.3% | 1,125 | $35,765,000 | $35,751,265 | 6 | Paramount Pictures | - |
| 20 | 20 | - | Children of Men | $863,000 | $809,190 | -$53,810 | -6.2% | 486 | $33,978,000 | $33,924,363 | 7 | Universal Pictures | - |
| 21 | 21 | - | Blood Diamond | $785,000 | $784,416 | -$584 | <0.1% | 451 | $55,105,000 | $55,104,016 | 10 | Warner Bros. | - |
| 22 | 22 | - | Arthur and the Invisibles | $675,000 | $721,512 | +$46,512 | +6.9% | 890 | $13,654,000 | $13,700,322 | 7 | Metro-Goldwyn-Mayer (MGM) | - |
| 23 | 23 | - | Charlotte's Web | $638,000 | $673,043 | +$35,043 | +5.5% | 820 | $80,922,000 | $80,957,299 | 9 | Paramount Pictures | - |
| 24 | 24 | - | Volver | $636,000 | $579,982 | -$56,018 | -8.8% | 301 | $11,002,000 | $10,946,263 | 15 | Sony Pictures Classics | - |
| 25 | 26 | +1 | The Painted Veil | $530,000 | $506,600 | -$23,400 | -4.4% | 275 | $6,400,000 | $6,376,914 | 8 | Warner Independent Pictures (WIP) | - |
| 26 | 25 | -1 | Happy Feet | $500,000 | $533,160 | +$33,160 | +6.6% | 483 | $193,350,000 | $193,383,272 | 13 | Warner Bros. | - |
| 27 | 27 | - | Venus | $490,000 | $470,071 | -$19,929 | -4.1% | 132 | $1,857,000 | $1,837,193 | 8 | Miramax | - |
| 28 | 28 | - | The Hitcher | $334,000 | $331,362 | -$2,638 | -0.8% | 580 | $16,240,000 | $16,237,220 | 4 | Rogue Pictures | - |
| 29 | 33 | +4 | The Last Sin Eater | $245,000 | - | - | - | 429 | $245,000 | - | 1 | The Bigger Picture | - |
| 30 | 32 | +2 | Happily N'Ever After | $230,000 | $250,491 | +$20,491 | +8.9% | 307 | $15,500,000 | $15,519,841 | 6 | Lionsgate | - |
| 31 | 35 | +4 | The Lives of Others | $223,000 | - | - | - | 9 | $230,000 | - | 1 | Sony Pictures Classics | - |
| 32 | 39 | +7 | The Good Shepherd | $187,000 | $171,925 | -$15,075 | -8.1% | 206 | $59,747,000 | $59,731,690 | 8 | Universal Pictures | - |
| 33 | 38 | +5 | Factory Girl | $184,000 | $195,698 | +$11,698 | +6.4% | 18 | $310,000 | $321,913 | 7 | Metro-Goldwyn-Mayer (MGM) | - |
| 34 | 44 | +10 | Alpha Dog | $131,000 | $140,140 | +$9,140 | +7% | 196 | $15,124,000 | $15,133,185 | 5 | Universal Pictures | - |
| 35 | 47 | +12 | Breaking and Entering | $89,900 | $90,031 | +$131 | +0.1% | 22 | $143,000 | $142,937 | 9 | The Weinstein Company | - |
