| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Pursuit of Happyness | $111,778 | -35.9% | 50 | -1 | $2,235 | $772,143 | 3 | Sony Pictures Releasing | false | false |
| 2 | 3 | Blood Diamond | $89,199 | -9.2% | 42 | -1 | $2,123 | $730,302 | 4 | Warner Bros. | false | false |
| 3 | 2 | Epic Movie | $65,730 | -50.2% | 40 | - | $1,643 | $632,689 | 3 | 20th Century Fox International | false | false |
| 4 | - | The Last King of Scotland | $46,243 | - | 20 | - | $2,312 | $46,243 | 1 | 20th Century Fox International | true | false |
| 5 | 4 | Rocky Balboa | $42,992 | -54.9% | 40 | - | $1,074 | $190,155 | 2 | 20th Century Fox International | false | false |
| 6 | 8 | Stranger Than Fiction | $42,253 | -23% | 21 | +1 | $2,012 | $127,312 | 2 | Roadshow Films | false | false |
| 7 | 7 | Casino Royale | $38,466 | -30.2% | 52 | -7 | $739 | $3,950,291 | 10 | Sony Pictures Releasing | false | false |
| 8 | 9 | The Queen | $38,284 | -28% | 18 | -34 | $2,126 | $1,352,684 | 8 | Icon Film Distribution | false | false |
| 9 | 12 | The History Boys | $35,841 | -18% | 10 | +1 | $3,584 | $157,795 | 3 | 20th Century Fox International | false | false |
| 10 | 14 | Babel | $31,811 | +1.6% | 17 | +3 | $1,871 | $379,464 | 6 | United International Pictures | false | false |
| 11 | 11 | Dreamgirls | $29,054 | -33.7% | 33 | -1 | $880 | $412,407 | 4 | Paramount Pictures International | false | false |
| 12 | 13 | Apocalypto | $27,687 | -32.8% | 30 | -4 | $922 | $606,380 | 5 | Hoyts Distribution | false | false |
| 13 | 5 | Happy Feet | $27,428 | -67.4% | 71 | -1 | $386 | $2,845,254 | 7 | Roadshow Films | false | false |
| 14 | 15 | A Prairie Home Companion | $24,929 | -5.6% | 27 | +3 | $923 | $68,078 | 2 | - | false | false |
| 15 | 6 | Open Season | $22,707 | -71.6% | 63 | -2 | $360 | $904,304 | 5 | Sony Pictures Releasing | false | false |
| 16 | 16 | Borat | $18,905 | -25.7% | 35 | -2 | $540 | $2,294,630 | 12 | 20th Century Fox International | false | false |
| 17 | 10 | Night at the Museum | $18,275 | -63.6% | 50 | -4 | $365 | $1,777,843 | 7 | 20th Century Fox International | false | false |
| 18 | - | Little Miss Sunshine | $14,011 | - | 24 | - | $583 | $704,816 | 18 | 20th Century Fox International | false | false |
| 19 | 20 | Volver | $10,934 | -18.2% | 19 | +4 | $575 | $93,621 | 4 | Dendy Films | false | false |
| 20 | 17 | The Valet | $10,814 | -52.9% | 18 | +1 | $600 | $429,761 | 8 | Rialto Distribution | false | false |
