| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | The Messengers | $14,500,000 | $14,713,321 | +$213,321 | +1.5% | 2,528 | $14,500,000 | $14,713,321 | 1 | Screen Gems | - |
| 2 | 2 | - | Because I Said So | $13,022,000 | $13,122,865 | +$100,865 | +0.8% | 2,526 | $13,022,000 | $13,122,865 | 1 | Universal Pictures | - |
| 3 | 3 | - | Epic Movie | $8,225,000 | $8,411,993 | +$186,993 | +2.3% | 2,840 | $29,369,000 | $29,555,556 | 2 | Twentieth Century Fox | - |
| 4 | 4 | - | Night at the Museum | $6,750,000 | $6,385,843 | -$364,157 | -5.4% | 3,003 | $225,365,000 | $225,001,335 | 7 | Twentieth Century Fox | - |
| 5 | 5 | - | Smokin' Aces | $6,324,000 | $6,113,345 | -$210,655 | -3.3% | 2,219 | $24,955,000 | $24,744,300 | 2 | Universal Pictures | - |
| 6 | 6 | - | Stomp the Yard | $4,200,000 | $4,055,791 | -$144,209 | -3.4% | 2,169 | $56,001,000 | $55,857,184 | 4 | Screen Gems | - |
| 7 | 7 | - | Dreamgirls | $4,048,000 | $4,000,521 | -$47,479 | -1.2% | 2,797 | $92,795,000 | $92,748,249 | 8 | DreamWorks | - |
| 8 | 8 | - | Pan's Labyrinth | $3,663,000 | $3,682,699 | +$19,699 | +0.5% | 1,082 | $21,696,000 | $21,715,849 | 6 | Picturehouse | - |
| 9 | 9 | - | The Pursuit of Happyness | $3,100,000 | $2,966,454 | -$133,546 | -4.3% | 2,233 | $157,351,000 | $157,217,102 | 8 | Sony Pictures Releasing | - |
| 10 | 10 | - | The Queen | $2,710,000 | - | - | - | 1,850 | $45,522,000 | - | 19 | Miramax | - |
| 11 | 11 | - | Catch and Release | $2,700,000 | $2,576,948 | -$123,052 | -4.6% | 1,622 | $12,011,000 | $11,887,958 | 2 | Sony Pictures Releasing | - |
| 12 | 12 | - | The Departed | $2,325,000 | $2,287,463 | -$37,537 | -1.6% | 1,453 | $128,621,000 | $128,583,307 | 18 | Warner Bros. | - |
| 13 | 13 | - | Freedom Writers | $1,908,000 | $1,860,547 | -$47,453 | -2.5% | 1,915 | $34,197,000 | $34,150,008 | 5 | Paramount Pictures | - |
| 14 | 14 | - | Notes on a Scandal | $1,775,000 | $1,750,593 | -$24,407 | -1.4% | 682 | $11,773,000 | $11,748,839 | 6 | Fox Searchlight Pictures | - |
| 15 | 16 | +1 | Letters from Iwo Jima | $1,745,000 | $1,696,356 | -$48,644 | -2.8% | 720 | $7,527,000 | $7,478,563 | 7 | Warner Bros. | - |
| 16 | 15 | -1 | Babel | $1,730,000 | $1,701,657 | -$28,343 | -1.6% | 1,090 | $29,744,000 | $29,715,747 | 15 | Paramount Vantage | - |
| 17 | 17 | - | The Last King of Scotland | $1,285,000 | $1,268,117 | -$16,883 | -1.3% | 528 | $9,641,000 | $9,624,115 | 19 | Fox Searchlight Pictures | - |
| 18 | 19 | +1 | Children of Men | $1,181,000 | $1,123,360 | -$57,640 | -4.9% | 826 | $32,785,000 | $32,726,893 | 6 | Universal Pictures | - |
| 19 | 18 | -1 | The Hitcher | $1,165,000 | - | - | - | 1,496 | $15,594,000 | - | 3 | Rogue Pictures | - |
| 20 | 23 | +3 | Charlotte's Web | $909,000 | $868,517 | -$40,483 | -4.5% | 1,058 | $80,092,000 | $80,053,644 | 8 | Paramount Pictures | - |
| 21 | 21 | - | Volver | $885,000 | - | - | - | 587 | $10,226,000 | - | 14 | Sony Pictures Classics | - |
| 22 | 22 | - | Blood Diamond | $880,000 | $871,401 | -$8,599 | -1% | 635 | $53,967,000 | $53,958,457 | 9 | Warner Bros. | - |
| 23 | 24 | +1 | Blood and Chocolate | $611,000 | $605,157 | -$5,843 | -1% | 1,200 | $3,125,000 | $3,119,191 | 2 | Metro-Goldwyn-Mayer (MGM) | - |
| 24 | 25 | +1 | Happy Feet | $555,000 | $591,291 | +$36,291 | +6.5% | 575 | $192,672,000 | $192,708,687 | 12 | Warner Bros. | - |
| 25 | 29 | +4 | Venus | $380,000 | $374,736 | -$5,264 | -1.4% | 96 | $1,232,000 | $1,226,956 | 7 | Miramax | - |
| 26 | 32 | +6 | Alpha Dog | $350,000 | $350,105 | +$105 | <0.1% | 446 | $14,833,000 | $14,832,545 | 4 | Universal Pictures | - |
| 27 | 34 | +7 | The Good Shepherd | $302,000 | $277,920 | -$24,080 | -8% | 341 | $59,486,000 | $59,462,475 | 7 | Universal Pictures | - |
| 28 | 35 | +7 | Happily N'Ever After | $266,000 | $276,317 | +$10,317 | +3.9% | 423 | $15,177,000 | $15,187,341 | 5 | Lionsgate | - |
| 29 | 46 | +17 | Factory Girl | $95,300 | $87,477 | -$7,823 | -8.2% | 3 | $95,300 | $87,477 | 6 | Metro-Goldwyn-Mayer (MGM) | - |
| 30 | 49 | +19 | Curse of the Golden Flower | $79,900 | $66,822 | -$13,078 | -16.4% | 55 | $6,379,000 | $6,366,049 | 7 | Sony Pictures Classics | - |
| 31 | 54 | +23 | The Italian | $42,200 | $38,151 | -$4,049 | -9.6% | 16 | $113,000 | $109,355 | 3 | Sony Pictures Classics | - |
| 32 | 63 | +31 | Breaking and Entering | $15,400 | $14,306 | -$1,094 | -7.1% | 2 | $47,600 | $46,462 | 8 | The Weinstein Company | - |
| 33 | 68 | +35 | An Unreasonable Man | $11,200 | $9,813 | -$1,387 | -12.4% | 1 | $18,700 | $17,324 | 1 | IFC Films | - |
