| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Epic Movie | $864,711 | -59.6% | 206 | -1 | $4,197 | $3,849,948 | 2 | 20th Century Fox International | false | false |
| 2 | 4 | Miss Potter | $799,339 | -28.6% | 240 | - | $3,330 | $2,554,950 | 2 | Icon Film Distribution | false | false |
| 3 | 2 | Deja Vu | $775,085 | -45% | 271 | -29 | $2,860 | $5,608,501 | 3 | Buena Vista International | false | false |
| 4 | 3 | The Pursuit of Happyness | $734,088 | -44.2% | 220 | -2 | $3,336 | $9,013,507 | 4 | Sony Pictures Releasing | false | false |
| 5 | - | Stranger Than Fiction | $598,525 | - | 124 | - | $4,826 | $631,150 | 1 | Roadshow Films | true | false |
| 6 | 7 | Dreamgirls | $460,479 | -29.3% | 169 | +30 | $2,724 | $2,846,647 | 3 | Paramount Pictures International | false | false |
| 7 | 8 | The Queen | $349,093 | -36.6% | 129 | - | $2,706 | $5,468,495 | 6 | Icon Film Distribution | false | false |
| 8 | 9 | Casino Royale | $348,908 | -28.3% | 159 | -42 | $2,194 | $24,178,884 | 9 | Sony Pictures Releasing | false | false |
| 9 | 6 | Night at the Museum | $333,224 | -61.3% | 245 | -34 | $1,360 | $18,066,933 | 6 | 20th Century Fox International | false | false |
| 10 | 10 | Blood Diamond | $329,431 | -30.2% | 144 | -26 | $2,287 | $5,581,163 | 5 | Warner Bros. | false | false |
| 11 | 5 | Happy Feet | $323,284 | -63.3% | 270 | -36 | $1,197 | $23,874,674 | 6 | Roadshow Films | false | false |
| 12 | 11 | Babel | $259,906 | -36.7% | 70 | +4 | $3,712 | $4,023,763 | 6 | United International Pictures | false | false |
| 13 | - | The Last King of Scotland | $244,957 | - | 58 | - | $4,223 | $297,082 | 1 | 20th Century Fox International | true | false |
| 14 | 15 | Pan's Labyrinth | $158,311 | -18% | 29 | +7 | $5,459 | $795,208 | 4 | Hopscotch Films | false | false |
| 15 | - | Perfume: The Story of a Murderer | $136,007 | - | 46 | - | $2,956 | $179,972 | 1 | Hoyts Distribution | true | false |
| 16 | 13 | Apocalypto | $126,105 | -51.8% | 102 | -55 | $1,236 | $2,385,979 | 4 | Icon Film Distribution | false | false |
| 17 | 14 | The Holiday | $115,866 | -50.2% | 112 | -49 | $1,034 | $9,726,086 | 8 | Universal Pictures | false | false |
| 18 | 12 | Flushed Away | $90,424 | -71.4% | 152 | -55 | $594 | $7,158,574 | 7 | United International Pictures | false | false |
| 19 | 17 | Breaking and Entering | $64,604 | -42.3% | 27 | +1 | $2,392 | $266,267 | 2 | Buena Vista International | false | false |
| 20 | - | Little Miss Sunshine | $47,874 | - | 28 | - | $1,709 | $5,162,889 | 17 | 20th Century Fox International | false | false |
