| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Epic Movie | $19,200,000 | $18,612,544 | -$587,456 | -3.1% | 2,801 | $19,200,000 | $18,612,544 | 1 | Twentieth Century Fox | - |
| 2 | 2 | - | Smokin' Aces | $14,262,000 | $14,638,755 | +$376,755 | +2.6% | 2,218 | $14,262,000 | $14,638,755 | 1 | Universal Pictures | - |
| 3 | 3 | - | Night at the Museum | $9,450,000 | $9,557,664 | +$107,664 | +1.1% | 3,241 | $216,738,000 | $216,845,623 | 6 | Twentieth Century Fox | - |
| 4 | 5 | +1 | Catch and Release | $8,000,000 | $7,658,898 | -$341,102 | -4.3% | 1,622 | $8,000,000 | $7,658,898 | 1 | Sony Pictures Releasing | - |
| 5 | 4 | -1 | Stomp the Yard | $7,800,000 | $7,685,565 | -$114,435 | -1.5% | 2,115 | $50,653,000 | $50,538,842 | 3 | Screen Gems | - |
| 6 | 6 | - | Dreamgirls | $6,618,000 | $6,741,985 | +$123,985 | +1.9% | 2,785 | $86,651,000 | $86,775,468 | 7 | DreamWorks | - |
| 7 | 7 | - | The Pursuit of Happyness | $5,000,000 | $4,983,325 | -$16,675 | -0.3% | 2,688 | $152,947,000 | $152,929,867 | 7 | Sony Pictures Releasing | - |
| 8 | 8 | - | Pan's Labyrinth | $4,505,000 | $4,774,578 | +$269,578 | +6% | 823 | $16,253,000 | $16,523,021 | 5 | Picturehouse | - |
| 9 | 9 | - | The Queen | $4,000,000 | - | - | - | 1,830 | $41,241,000 | - | 18 | Miramax | - |
| 10 | 10 | - | The Hitcher | $3,598,000 | - | - | - | 2,836 | $13,398,000 | - | 2 | Rogue Pictures | - |
| 11 | 11 | - | Freedom Writers | $3,487,000 | $3,514,548 | +$27,548 | +0.8% | 2,273 | $31,285,000 | $31,312,123 | 4 | Paramount Pictures | - |
| 12 | 12 | - | The Departed | $3,045,000 | $3,365,481 | +$320,481 | +10.5% | 1,453 | $124,917,000 | $125,237,852 | 17 | Warner Bros. | - |
| 13 | 14 | +1 | Babel | $2,581,000 | $2,561,053 | -$19,947 | -0.8% | 1,090 | $27,246,000 | $27,226,241 | 14 | Paramount Vantage | - |
| 14 | 13 | -1 | Notes on a Scandal | $2,550,000 | $2,603,703 | +$53,703 | +2.1% | 641 | $9,033,000 | $9,087,135 | 5 | Fox Searchlight Pictures | - |
| 15 | 16 | +1 | Blood and Chocolate | $2,103,000 | $2,074,300 | -$28,700 | -1.4% | 1,200 | $2,103,000 | $2,074,300 | 1 | Metro-Goldwyn-Mayer (MGM) | - |
| 16 | 15 | -1 | Children of Men | $2,022,000 | $2,183,195 | +$161,195 | +8% | 1,273 | $30,749,000 | $30,909,838 | 5 | Universal Pictures | - |
| 17 | 17 | - | Letters from Iwo Jima | $1,710,000 | $1,867,326 | +$157,326 | +9.2% | 415 | $4,915,000 | $5,072,065 | 6 | Warner Bros. | - |
| 18 | 19 | +1 | The Last King of Scotland | $1,650,000 | $1,674,900 | +$24,900 | +1.5% | 501 | $7,714,000 | $7,739,235 | 18 | Fox Searchlight Pictures | - |
| 19 | 20 | +1 | Charlotte's Web | $1,428,000 | $1,496,105 | +$68,105 | +4.8% | 1,345 | $78,794,000 | $78,862,500 | 7 | Paramount Pictures | - |
| 20 | 21 | +1 | Blood Diamond | $1,200,000 | $1,222,485 | +$22,485 | +1.9% | 690 | $52,618,000 | $52,640,838 | 8 | Warner Bros. | - |
| 21 | 23 | +2 | Volver | $1,151,000 | - | - | - | 689 | $8,900,000 | - | 13 | Sony Pictures Classics | - |
| 22 | 22 | - | Alpha Dog | $1,040,000 | $1,165,725 | +$125,725 | +12.1% | 1,005 | $13,920,000 | $14,045,245 | 3 | Universal Pictures | - |
| 23 | 25 | +2 | Happy Feet | $900,000 | $920,214 | +$20,214 | +2.2% | 650 | $191,907,000 | $191,927,188 | 11 | Warner Bros. | - |
| 24 | 26 | +2 | We Are Marshall | $830,000 | $786,362 | -$43,638 | -5.3% | 940 | $42,269,000 | $42,224,971 | 6 | Warner Bros. | - |
| 25 | 27 | +2 | The Good Shepherd | $669,000 | $725,610 | +$56,610 | +8.5% | 722 | $58,908,000 | $58,964,680 | 6 | Universal Pictures | - |
| 26 | 28 | +2 | The Painted Veil | $660,000 | $695,073 | +$35,073 | +5.3% | 287 | $4,830,000 | $4,864,513 | 6 | Warner Independent Pictures (WIP) | - |
| 27 | 29 | +2 | Casino Royale | $600,000 | $609,192 | +$9,192 | +1.5% | 364 | $165,311,000 | $165,320,608 | 11 | Sony Pictures Releasing | - |
| 28 | 32 | +4 | Happily N'Ever After | $505,000 | $549,141 | +$44,141 | +8.7% | 660 | $14,805,000 | $14,798,151 | 4 | Lionsgate | - |
| 29 | 33 | +4 | Venus | $336,000 | $343,941 | +$7,941 | +2.4% | 59 | $707,000 | $715,173 | 6 | Miramax | - |
| 30 | 35 | +5 | Apocalypto | $211,000 | $228,685 | +$17,685 | +8.4% | 175 | $50,205,000 | $50,222,634 | 8 | Walt Disney Studios Motion Pictures | - |
| 31 | 42 | +11 | Seraphim Falls | $162,000 | $155,560 | -$6,440 | -4% | 52 | $162,000 | $155,560 | 1 | IDP Distribution | - |
| 32 | 45 | +13 | Curse of the Golden Flower | $135,000 | $135,548 | +$548 | +0.4% | 91 | $6,243,000 | $6,243,989 | 6 | Sony Pictures Classics | - |
| 33 | 57 | +24 | The Italian | $28,300 | $27,823 | -$477 | -1.7% | 8 | $61,200 | $60,774 | 2 | Sony Pictures Classics | - |
| 34 | 62 | +28 | Breaking and Entering | $20,700 | $21,160 | +$460 | +2.2% | 2 | $20,700 | $21,160 | 7 | The Weinstein Company | - |
