| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Manual of Love 2 | $8,025,468 | - | 590 | - | $13,602 | $8,084,115 | 1 | Filmauro | true | false |
| 2 | 1 | The Pursuit of Happyness | $3,967,493 | -15.5% | 441 | +50 | $8,996 | $11,005,116 | 2 | Medusa Distribuzione | false | false |
| 3 | 2 | Rocky Balboa | $1,587,715 | -57.4% | 324 | -7 | $4,900 | $6,672,175 | 2 | 20th Century Fox International | false | false |
| 4 | 3 | Casino Royale | $1,039,873 | -52.4% | 280 | -119 | $3,713 | $9,048,512 | 3 | Sony Pictures Releasing | false | false |
| 5 | 4 | Apocalypto | $801,894 | -54.9% | 243 | -83 | $3,299 | $7,696,624 | 3 | Eagle Pictures | false | false |
| 6 | - | The Guardian | $552,315 | - | 199 | - | $2,775 | $552,315 | 1 | Eagle Pictures | true | false |
| 7 | - | Bobby | $485,266 | - | 147 | - | $3,301 | $485,266 | 1 | 01 Distribution | true | false |
| 8 | 6 | Flushed Away | $292,475 | -46.8% | 171 | -62 | $1,710 | $8,085,395 | 5 | United International Pictures | false | false |
| 9 | - | The Science of Sleep | $169,337 | - | 50 | - | $3,386 | $191,694 | 1 | Mikado Film | true | false |
| 10 | 5 | A Good Year | $163,269 | -71% | 92 | -111 | $1,774 | $6,887,179 | 6 | Medusa Distribuzione | false | false |
| 11 | 11 | The Boss of It All | $162,823 | -37% | 51 | -7 | $3,192 | $876,746 | 3 | Lucky Red | false | false |
| 12 | 9 | Eragon | $161,245 | -67.6% | 88 | -97 | $1,832 | $12,789,210 | 5 | 20th Century Fox International | false | false |
| 13 | 7 | Deja Vu | $160,179 | -69.1% | 69 | -95 | $2,321 | $9,844,813 | 6 | Buena Vista International | false | false |
| 14 | 10 | The Prestige | $151,938 | -64.5% | 62 | -83 | $2,450 | $4,990,523 | 5 | Warner Bros. | false | false |
| 15 | 17 | Lights in the Dusk | $65,644 | -30% | 27 | - | $2,431 | $200,598 | 2 | BIM Distribuzione | false | false |
| 16 | 14 | Salty Air | $54,755 | -53.9% | 36 | -13 | $1,520 | $459,506 | 3 | 01 Distribution | false | false |
| 17 | - | Little Red Flowers | $51,799 | - | 16 | - | $3,237 | $115,894 | 2 | Istituto Luce | false | false |
| 18 | 16 | My Best Friend | $47,177 | -51.8% | 22 | -16 | $2,144 | $1,854,317 | 7 | Lucky Red | false | false |
| 19 | 18 | After the Wedding | $39,559 | -46.1% | 21 | -12 | $1,883 | $502,533 | 5 | Teodora Film | false | false |
| 20 | 8 | Natale a New York | $38,133 | -92.5% | 28 | -181 | $1,361 | $30,437,121 | 6 | Filmauro | false | false |
