| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Night at the Museum | $37,800,000 | $36,766,905 | -$1,033,095 | -2.7% | 3,768 | $116,855,000 | $115,822,154 | 2 | Twentieth Century Fox | - |
| 2 | 2 | - | The Pursuit of Happyness | $19,300,000 | $19,362,441 | +$62,441 | +0.3% | 2,870 | $98,346,000 | $98,411,670 | 3 | Sony Pictures Releasing | - |
| 3 | 3 | - | Dreamgirls | $15,500,000 | $14,100,050 | -$1,399,950 | -9% | 852 | $38,464,000 | $37,064,395 | 3 | DreamWorks | - |
| 4 | 4 | - | Charlotte's Web | $12,000,000 | $11,674,784 | -$325,216 | -2.7% | 3,745 | $52,858,000 | $52,532,601 | 3 | Paramount Pictures | - |
| 5 | 6 | +1 | Rocky Balboa | $11,350,000 | $10,572,458 | -$777,542 | -6.9% | 3,019 | $48,822,000 | $47,940,632 | 2 | Metro-Goldwyn-Mayer (MGM) | - |
| 6 | 5 | -1 | The Good Shepherd | $11,245,000 | $11,000,510 | -$244,490 | -2.2% | 2,218 | $35,311,000 | $35,066,495 | 2 | Universal Pictures | - |
| 7 | 7 | - | Eragon | $8,475,000 | $8,206,585 | -$268,415 | -3.2% | 2,985 | $56,689,000 | $56,420,434 | 3 | Twentieth Century Fox | - |
| 8 | 8 | - | We Are Marshall | $8,025,000 | $8,089,931 | +$64,931 | +0.8% | 2,606 | $25,063,000 | $25,128,312 | 2 | Warner Bros. | - |
| 9 | 9 | - | Happy Feet | $7,835,000 | $7,650,181 | -$184,819 | -2.4% | 2,565 | $176,152,000 | $175,967,627 | 7 | Warner Bros. | - |
| 10 | 10 | - | The Holiday | $6,780,000 | $6,718,286 | -$61,714 | -0.9% | 2,698 | $50,011,000 | $50,029,085 | 4 | Sony Pictures Releasing | - |
| 11 | 11 | - | Blood Diamond | $5,000,000 | $4,895,871 | -$104,129 | -2.1% | 1,920 | $35,831,000 | $35,726,534 | 4 | Warner Bros. | - |
| 12 | 12 | - | Casino Royale | $4,500,000 | $4,601,492 | +$101,492 | +2.3% | 1,543 | $153,425,000 | $153,531,944 | 7 | Sony Pictures Releasing | - |
| 13 | 13 | - | Black Christmas | $4,120,000 | $3,723,364 | -$396,636 | -9.6% | 1,544 | $11,272,000 | $10,917,918 | 1 | Metro-Goldwyn-Mayer (MGM) | - |
| 14 | 14 | - | Apocalypto | $3,402,000 | $3,264,798 | -$137,202 | -4% | 2,023 | $42,792,000 | $42,654,236 | 4 | Walt Disney Studios Motion Pictures | - |
| 15 | 15 | - | The Nativity Story | $1,506,818 | - | - | - | 1,824 | $36,276,572 | - | 5 | New Line Cinema | - |
| 16 | 16 | - | Unaccompanied Minors | $995,000 | $966,870 | -$28,130 | -2.8% | 1,021 | $15,022,000 | $14,993,733 | 4 | Warner Bros. | - |
| 17 | 20 | +3 | Borat | $900,000 | $570,744 | -$329,256 | -36.6% | 399 | $125,931,000 | $125,601,414 | 9 | Twentieth Century Fox | - |
| 18 | 17 | -1 | The Queen | $872,000 | - | - | - | 302 | $28,135,000 | - | 14 | Miramax | - |
| 19 | 18 | -1 | Deja Vu | $815,000 | $777,278 | -$37,722 | -4.6% | 655 | $61,612,000 | $61,574,479 | 6 | Walt Disney Studios Motion Pictures | - |
| 20 | 19 | -1 | Volver | $765,000 | $619,913 | -$145,087 | -19% | 117 | $5,006,000 | $4,753,067 | 9 | Sony Pictures Classics | - |
| 21 | 21 | - | Pan's Labyrinth | $595,000 | $568,641 | -$26,359 | -4.4% | 17 | $595,000 | $568,641 | 1 | Picturehouse | - |
| 22 | 22 | - | Children of Men | $532,000 | $501,003 | -$30,997 | -5.8% | 16 | $1,114,000 | $1,082,804 | 1 | Universal Pictures | - |
| 23 | 24 | +1 | Babel | $523,000 | $478,624 | -$44,376 | -8.5% | 233 | $19,869,000 | $19,825,138 | 10 | Paramount Vantage | - |
| 24 | 23 | -1 | The Santa Clause 3: The Escape Clause | $506,000 | $489,964 | -$16,036 | -3.2% | 611 | $83,566,000 | $83,549,047 | 9 | Walt Disney Studios Motion Pictures | - |
| 25 | 25 | - | Curse of the Golden Flower | $502,000 | $448,268 | -$53,732 | -10.7% | 60 | $1,574,000 | $1,520,292 | 2 | Sony Pictures Classics | - |
| 26 | 26 | - | Notes on a Scandal | $408,000 | $414,487 | +$6,487 | +1.6% | 22 | $607,000 | $613,344 | 1 | Fox Searchlight Pictures | - |
| 27 | 37 | +10 | The Good German | $120,000 | $116,119 | -$3,881 | -3.2% | 19 | $463,000 | $458,653 | 3 | Warner Bros. | - |
| 28 | 38 | +10 | Letters from Iwo Jima | $92,000 | $87,932 | -$4,068 | -4.4% | 5 | $320,000 | $316,369 | 2 | Warner Bros. | - |
| 29 | 48 | +19 | Perfume: The Story of a Murderer | $39,000 | $37,079 | -$1,921 | -4.9% | 3 | $74,000 | $57,449 | 1 | DreamWorks | - |
| 30 | 49 | +19 | Venus | $33,000 | $34,329 | +$1,329 | +4% | 3 | $112,000 | $113,518 | 2 | Miramax | - |
| 31 | 67 | +36 | Miss Potter | $9,100 | $9,653 | +$553 | +6.1% | 2 | $9,100 | $9,653 | 1 | Metro-Goldwyn-Mayer (MGM) | - |
| 32 | 70 | +38 | The Dead Girl | $6,700 | $6,613 | -$87 | -1.3% | 2 | $6,700 | $6,613 | 1 | First Look International | - |
