| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Happy Feet | $2,767,880 | - | 480 | - | $5,766 | $4,610,514 | 1 | Warner Bros. | true | false |
| 2 | 1 | Deja Vu | $2,087,436 | -15.4% | 408 | -24 | $5,116 | $6,314,529 | 2 | Buena Vista International | false | false |
| 3 | 2 | Flushed Away | $1,830,875 | -10.3% | 439 | -2 | $4,170 | $5,385,033 | 2 | United International Pictures | false | false |
| 4 | 3 | Casino Royale | $1,555,961 | -22.7% | 478 | -19 | $3,255 | $9,722,873 | 3 | Sony Pictures Releasing | false | false |
| 5 | - | The Holiday | $1,546,147 | - | 295 | - | $5,241 | $2,602,332 | 1 | United International Pictures | true | false |
| 6 | 4 | Perfume: The Story of a Murderer | $1,296,523 | -16% | 308 | -1 | $4,209 | $6,940,443 | 3 | Filmax | false | false |
| 7 | 5 | The Illusionist | $1,233,570 | +23.7% | 206 | +1 | $5,988 | $6,635,344 | 4 | - | false | false |
| 8 | 6 | Isi/Disi: Alto voltaje | $604,440 | -23.1% | 297 | -4 | $2,035 | $1,963,204 | 2 | Azteca Films | false | false |
| 9 | 7 | Summer Rain | $534,949 | -28.4% | 289 | - | $1,851 | $1,808,414 | 2 | 20th Century Fox International | false | false |
| 10 | 10 | The Departed | $262,167 | -15% | 127 | -159 | $2,064 | $11,362,028 | 7 | Warner Bros. | false | false |
| 11 | 13 | The Nativity Story | $258,599 | +3.4% | 220 | +1 | $1,175 | $719,832 | 2 | TriPictures | false | false |
| 12 | 8 | Open Season | $227,398 | -36.2% | 286 | -50 | $795 | $5,213,071 | 5 | Sony Pictures Releasing | false | false |
| 13 | 12 | Scoop | $226,113 | -21.6% | 109 | -14 | $2,074 | $6,913,906 | 7 | On Pictures | false | false |
| 14 | 9 | Borat | $164,986 | -47.8% | 164 | -89 | $1,006 | $2,826,970 | 4 | 20th Century Fox International | false | false |
| 15 | 11 | Saw III | $161,490 | -46.7% | 153 | -84 | $1,055 | $6,740,743 | 5 | Buena Vista International | false | false |
| 16 | 14 | The Queen | $97,154 | -23.8% | 54 | -21 | $1,799 | $1,985,677 | 5 | Vértigo Films | false | false |
| 17 | 16 | Little Miss Sunshine | $89,481 | +14.4% | 34 | -3 | $2,631 | $2,616,378 | 8 | 20th Century Fox International | false | false |
| 18 | - | Palais royal! | $88,961 | - | 100 | - | $889 | $152,123 | 1 | Alta Films | true | false |
| 19 | 18 | Into Great Silence | $76,054 | +16.6% | 15 | +1 | $5,070 | $316,440 | 3 | Karma Films | false | false |
