| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Happy Feet | $43,183,255 | - | 3,804 | - | $11,352 | $99,256,766 | 2 | Warner Bros. | false | false |
| 2 | - | Casino Royale | $38,324,799 | - | 3,443 | - | $11,131 | $94,053,658 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | Deja Vu | $25,110,863 | - | 3,108 | - | $8,079 | $28,649,398 | 1 | Walt Disney Studios Motion Pictures | true | false |
| 4 | - | Deck the Halls | $14,893,450 | - | 3,205 | - | $4,646 | $16,916,923 | 1 | Twentieth Century Fox | true | false |
| 5 | - | Borat | $12,854,561 | - | 2,580 | - | $4,982 | $109,136,807 | 4 | Twentieth Century Fox | false | false |
| 6 | - | The Santa Clause 3: The Escape Clause | $12,008,435 | - | 3,043 | - | $3,946 | $67,073,095 | 4 | Walt Disney Studios Motion Pictures | false | false |
| 7 | - | Stranger Than Fiction | $7,033,423 | - | 2,258 | - | $3,114 | $32,504,604 | 3 | Sony Pictures Releasing | false | false |
| 8 | - | Flushed Away | $6,550,149 | - | 2,621 | - | $2,499 | $57,266,350 | 4 | DreamWorks | false | false |
| 9 | - | Bobby | $6,012,101 | - | 1,667 | - | $3,606 | $6,100,358 | 2 | - | false | false |
| 10 | - | The Fountain | $4,630,809 | - | 1,472 | - | $3,145 | $5,456,908 | 1 | Warner Bros. | true | false |
| 11 | - | Tenacious D in the Pick of Destiny | $4,030,879 | - | 1,919 | - | $2,100 | $5,212,156 | 1 | New Line Cinema | true | true |
| 12 | - | The Queen | $2,949,471 | - | 653 | - | $4,516 | $20,970,016 | 9 | Miramax | false | true |
| 13 | - | Babel | $2,293,808 | - | 902 | - | $2,543 | $15,194,482 | 5 | Paramount Vantage | false | false |
| 14 | - | For Your Consideration | $2,281,499 | - | 623 | - | $3,662 | $3,017,715 | 2 | Warner Independent Pictures (WIP) | false | false |
| 15 | - | The Departed | $2,043,540 | - | 910 | - | $2,245 | $116,748,722 | 8 | Warner Bros. | false | false |
| 16 | - | Saw III | $1,981,868 | - | 1,044 | - | $1,898 | $78,090,811 | 5 | Lionsgate Films | false | false |
| 17 | - | Dhoom 2 | $1,298,477 | - | 63 | - | $20,610 | $1,298,477 | 1 | Yash Raj Films | true | false |
| 18 | - | Let's Go to Prison | $1,226,560 | - | 1,495 | - | $820 | $4,096,935 | 2 | Universal Pictures | false | false |
| 19 | - | The Prestige | $1,072,195 | - | 565 | - | $1,897 | $51,099,913 | 6 | Walt Disney Studios Motion Pictures | false | false |
| 20 | - | Flags of Our Fathers | $362,153 | - | 362 | - | $1,000 | $33,306,143 | 6 | DreamWorks | false | false |
| 21 | - | A Good Year | $350,801 | - | 692 | - | $506 | $7,145,304 | 3 | Twentieth Century Fox | false | false |
| 22 | - | The Polar Express 2006 IMAX Release | $255,690 | - | 24 | - | $10,653 | $403,159 | 2 | Warner Bros. | false | false |
| 23 | - | Fast Food Nation | $237,009 | - | 252 | - | $940 | $780,641 | 2 | - | false | false |
| 24 | - | Flicka | $186,351 | - | 287 | - | $649 | $20,440,018 | 6 | Twentieth Century Fox | false | false |
| 25 | - | Marie Antoinette | $177,759 | - | 123 | - | $1,445 | $15,845,821 | 6 | Sony Pictures Releasing | false | false |
| 26 | - | Open Season | $169,254 | - | 206 | - | $821 | $84,194,583 | 9 | Sony Pictures Releasing | false | false |
| 27 | - | The Illusionist | $159,344 | - | 175 | - | $910 | $39,401,642 | 15 | Yari Film Group Releasing | false | false |
| 28 | - | The Wedding Weekend | $146,289 | - | 68 | - | $2,151 | $637,546 | 5 | The Weinstein Company | false | false |
| 29 | - | Deep Sea | $144,059 | - | 29 | - | $4,967 | $21,235,614 | 39 | Warner Bros. | false | false |
| 30 | - | Little Miss Sunshine | $138,694 | - | 114 | - | $1,216 | $58,938,608 | 18 | - | false | false |
| 31 | - | Man of the Year | $122,320 | - | 208 | - | $588 | $37,301,140 | 7 | Universal Pictures | false | false |
| 32 | - | The Marine | $120,667 | - | 153 | - | $788 | $18,512,339 | 7 | Twentieth Century Fox | false | false |
| 33 | - | The History Boys | $118,305 | - | 7 | - | $16,900 | $142,379 | 1 | - | true | false |
| 34 | - | Jackass Number Two | $82,157 | - | 152 | - | $540 | $72,755,517 | 10 | Paramount Pictures | false | false |
| 35 | - | School for Scoundrels | $81,509 | - | 137 | - | $594 | $17,686,645 | 9 | - | false | false |
| 36 | - | The Last King of Scotland | $77,916 | - | 22 | - | $3,541 | $3,368,128 | 9 | - | false | false |
| 37 | - | The Return | $57,268 | - | 421 | - | $136 | $7,300,682 | 3 | Rogue Pictures | false | false |
| 38 | - | Harsh Times | $54,155 | - | 122 | - | $443 | $3,304,691 | 3 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 39 | - | Fur: An Imaginary Portrait of Diane Arbus | $39,212 | - | 39 | - | $1,005 | $148,913 | 3 | Picturehouse | false | false |
| 40 | - | Employee of the Month | $38,788 | - | 63 | - | $615 | $28,435,406 | 8 | Lionsgate Films | false | false |
| 41 | - | Copying Beethoven | $37,946 | - | 11 | - | $3,449 | $210,945 | 3 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 42 | - | The Science of Sleep | $20,107 | - | 18 | - | $1,117 | $4,602,841 | 10 | Warner Independent Pictures (WIP) | false | false |
| 43 | - | Everyone's Hero | $11,440 | - | 47 | - | $243 | $14,514,455 | 11 | Twentieth Century Fox | false | false |
| 44 | - | The Devil Wears Prada | $11,230 | - | 37 | - | $303 | $124,721,367 | 22 | Twentieth Century Fox | false | false |
| 45 | - | The U.S. vs. John Lennon | $9,828 | - | 14 | - | $702 | $1,102,937 | 11 | Lionsgate Films | false | false |
| 46 | - | Deliver Us from Evil | $8,685 | - | 10 | - | $868 | $196,585 | 7 | Lionsgate Films | false | false |
| 47 | - | Infamous | $2,688 | - | 4 | - | $672 | $1,141,666 | 7 | Warner Independent Pictures (WIP) | false | false |
| 48 | - | Who the #$&% Is Jackson Pollock? | $2,537 | - | 1 | - | $2,537 | $12,571 | 2 | Picturehouse | false | false |
| 49 | - | Hannari: Geisha Modern | $1,907 | - | 1 | - | $1,907 | $14,974 | - | - | - | false |
| 50 | - | Flyboys | $985 | - | 6 | - | $164 | $13,005,938 | 10 | Metro-Goldwyn-Mayer (MGM) | false | false |
