| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Saw III | $1,495,622 | -48.2% | 300 | - | $4,985 | $4,985,686 | 2 | Buena Vista International | false | false |
| 2 | - | The Illusionist | $1,367,265 | - | 203 | - | $6,735 | $1,367,265 | 1 | - | true | false |
| 3 | 2 | Open Season | $1,336,253 | -20.1% | 400 | - | $3,340 | $3,189,992 | 2 | Sony Pictures Releasing | false | false |
| 4 | 3 | The Departed | $1,080,602 | -20.1% | 355 | -12 | $3,043 | $9,189,559 | 4 | Warner Bros. | false | false |
| 5 | - | Borat | $1,037,862 | - | 288 | - | $3,603 | $1,037,862 | 1 | 20th Century Fox International | true | false |
| 6 | 5 | Scoop | $668,713 | -20.4% | 161 | - | $4,153 | $5,233,321 | 4 | On Pictures | false | false |
| 7 | 4 | A Good Year | $650,970 | -32.4% | 297 | -3 | $2,191 | $3,444,184 | 3 | 20th Century Fox International | false | false |
| 8 | 6 | Goya's Ghosts | $521,684 | -37% | 363 | +1 | $1,437 | $1,655,523 | 2 | Warner Bros. | false | false |
| 9 | 7 | The Queen | $397,209 | -26.9% | 178 | -7 | $2,231 | $1,183,450 | 2 | Vértigo Films | false | false |
| 10 | - | DOA: Dead or Alive | $325,500 | - | 244 | - | $1,334 | $325,500 | 1 | Filmax | true | false |
| 11 | 8 | Nobody Is Perfect | $304,595 | -33.3% | 178 | -14 | $1,711 | $3,181,464 | 4 | Sony Pictures Releasing | false | false |
| 12 | 10 | Pan's Labyrinth | $299,414 | -30.3% | 199 | -51 | $1,504 | $8,774,883 | 6 | Warner Bros. | false | false |
| 13 | 9 | GAL | $200,526 | -54.9% | 232 | -103 | $864 | $1,915,108 | 3 | 20th Century Fox International | false | false |
| 14 | - | Trastorno | $191,786 | - | 137 | - | $1,399 | $191,786 | 1 | DeAPlaneta | true | false |
| 15 | 12 | Little Miss Sunshine | $172,083 | -19.3% | 92 | -17 | $1,870 | $2,088,658 | 5 | 20th Century Fox International | false | false |
| 16 | 16 | Barnyard | $126,246 | -31.1% | 178 | -54 | $709 | $2,170,282 | 4 | United International Pictures | false | false |
| 17 | 13 | The Borgia | $116,199 | -44.7% | 97 | -60 | $1,197 | $8,299,543 | 7 | DeAPlaneta | false | false |
| 18 | 15 | The Black Dahlia | $95,608 | -48.4% | 72 | -59 | $1,327 | $3,579,354 | 5 | TriPictures | false | false |
| 19 | 14 | My Name Is Juani | $90,776 | -54.9% | 103 | -47 | $881 | $2,971,263 | 5 | Manga Entertainment | false | false |
| 20 | 11 | The Texas Chainsaw Massacre: The Beginning | $88,256 | -64.9% | 104 | -57 | $848 | $1,237,205 | 3 | TriPictures | false | false |
