| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Departed | $1,873,561 | -21.3% | 369 | -6 | $5,077 | $5,779,425 | 2 | Warner Bros. | false | false |
| 2 | - | A Good Year | $1,255,564 | - | 299 | - | $4,199 | $1,255,564 | 1 | 20th Century Fox International | true | false |
| 3 | 2 | Scoop | $1,045,597 | -10.9% | 159 | - | $6,576 | $3,051,162 | 2 | On Pictures | false | false |
| 4 | - | GAL | $866,110 | - | 350 | - | $2,474 | $866,110 | 1 | 20th Century Fox International | true | false |
| 5 | 4 | Nobody Is Perfect | $758,648 | -15.6% | 201 | - | $3,774 | $2,197,494 | 2 | Sony Pictures Releasing | false | false |
| 6 | 3 | Pan's Labyrinth | $746,471 | -21.1% | 299 | -3 | $2,496 | $7,637,020 | 4 | Warner Bros. | false | false |
| 7 | - | The Texas Chainsaw Massacre: The Beginning | $714,976 | - | 160 | - | $4,468 | $714,976 | 1 | TriPictures | true | false |
| 8 | 6 | Barnyard | $655,466 | +0.6% | 238 | +18 | $2,754 | $1,735,983 | 2 | United International Pictures | false | false |
| 9 | 8 | The Borgia | $423,081 | -28.7% | 246 | -48 | $1,719 | $7,672,482 | 5 | DeAPlaneta | false | false |
| 10 | 7 | My Name Is Juani | $422,868 | -32.8% | 182 | -4 | $2,323 | $2,525,034 | 3 | Manga Entertainment | false | false |
| 11 | 5 | The Black Dahlia | $416,066 | -37.8% | 230 | -10 | $1,808 | $3,088,275 | 3 | TriPictures | false | false |
| 12 | 9 | The Devil Wears Prada | $325,843 | -42% | 225 | -67 | $1,448 | $7,724,023 | 5 | 20th Century Fox International | false | false |
| 13 | 11 | Little Miss Sunshine | $323,680 | -12.2% | 156 | -7 | $2,074 | $1,525,979 | 3 | 20th Century Fox International | false | false |
| 14 | 10 | Children of Men | $259,685 | -39% | 165 | +9 | $1,573 | $1,770,037 | 3 | United International Pictures | false | false |
| 15 | - | Jackass Number Two | $257,454 | - | 100 | - | $2,574 | $257,454 | 1 | United International Pictures | true | false |
| 16 | 14 | Copying Beethoven | $147,907 | -22.2% | 77 | -10 | $1,920 | $830,351 | 3 | Notro Films | false | false |
| 17 | - | An Inconvenient Truth | $115,455 | - | 51 | - | $2,263 | $115,455 | 1 | United International Pictures | true | false |
| 18 | - | The Lost City | $91,026 | - | 56 | - | $1,625 | $91,026 | 1 | Manga Entertainment | true | false |
| 19 | 18 | Hoodwinked! | $86,527 | -9.3% | 114 | -22 | $759 | $3,920,591 | 7 | Manga Entertainment | false | false |
| 20 | 12 | The Guardian | $77,160 | -62.8% | 105 | -182 | $734 | $2,984,018 | 4 | Buena Vista International | false | false |
