| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | The Departed | $27,015,000 | $26,887,467 | -$127,533 | -0.5% | 3,017 | $27,015,000 | $26,887,467 | 1 | Warner Bros. | - |
| 2 | 2 | - | The Texas Chainsaw Massacre: The Beginning | $19,150,000 | - | - | - | 2,820 | $19,150,000 | - | 1 | New Line Cinema | - |
| 3 | 3 | - | Open Season | $16,000,000 | $15,625,324 | -$374,676 | -2.3% | 3,833 | $44,129,000 | $43,754,064 | 2 | Sony Pictures Releasing | - |
| 4 | 4 | - | Employee of the Month | $11,800,000 | $11,407,751 | -$392,249 | -3.3% | 2,579 | $11,800,000 | $11,407,751 | 1 | Lionsgate | - |
| 5 | 5 | - | The Guardian | $9,643,000 | $9,568,092 | -$74,908 | -0.8% | 3,241 | $32,394,000 | $32,319,809 | 2 | Walt Disney Studios Motion Pictures | - |
| 6 | 6 | - | Jackass Number Two | $6,400,000 | $6,516,968 | +$116,968 | +1.8% | 3,007 | $62,693,000 | $62,810,339 | 3 | Paramount Pictures | - |
| 7 | 7 | - | School for Scoundrels | $3,413,000 | $3,433,587 | +$20,587 | +0.6% | 3,007 | $13,968,000 | $13,988,365 | 2 | Metro-Goldwyn-Mayer (MGM) | - |
| 8 | 8 | - | Gridiron Gang | $2,300,000 | $2,236,784 | -$63,216 | -2.7% | 2,228 | $36,621,000 | $36,557,430 | 4 | Sony Pictures Releasing | - |
| 9 | 9 | - | Fearless | $2,198,000 | - | - | - | 1,617 | $21,660,000 | - | 3 | Rogue Pictures | - |
| 10 | 10 | - | The Illusionist | $1,825,000 | $1,906,510 | +$81,510 | +4.5% | 1,149 | $34,068,000 | $34,148,522 | 8 | Yari Film Group Releasing | - |
| 11 | 11 | - | Little Miss Sunshine | $1,280,000 | $1,278,904 | -$1,096 | <0.1% | 824 | $55,011,000 | $55,010,203 | 11 | Fox Searchlight Pictures | - |
| 12 | 12 | - | Trailer Park Boys: The Movie | $1,200,000 | - | - | - | 181 | $1,200,000 | - | 1 | Alliance Atlantis Vivafilm | - |
| 13 | 13 | - | Flyboys | $1,032,000 | $1,039,073 | +$7,073 | +0.7% | 1,471 | $11,827,000 | $11,833,647 | 3 | Metro-Goldwyn-Mayer (MGM) | - |
| 14 | 14 | - | Facing the Giants | $979,000 | - | - | - | 418 | $2,722,000 | - | 2 | IDP Distribution | - |
| 15 | 15 | - | The Science of Sleep | $680,000 | $680,420 | +$420 | <0.1% | 221 | $2,704,000 | $2,704,212 | 3 | Warner Independent Pictures (WIP) | - |
| 16 | 16 | - | The Black Dahlia | $577,000 | $553,115 | -$23,885 | -4.1% | 930 | $22,053,000 | $22,028,485 | 4 | Universal Pictures | - |
| 17 | 18 | +1 | The Queen | $401,000 | - | - | - | 11 | $634,000 | - | 2 | Miramax | - |
| 18 | 20 | +2 | Invincible | $392,309 | - | - | - | 551 | $57,011,536 | - | 7 | Walt Disney Studios Motion Pictures | - |
| 19 | 21 | +2 | The Last Kiss | $353,000 | $364,052 | +$11,052 | +3.1% | 403 | $11,198,000 | $11,209,469 | 4 | DreamWorks | - |
| 20 | 22 | +2 | Barnyard | $344,000 | $357,980 | +$13,980 | +4.1% | 523 | $71,700,000 | $71,713,703 | 10 | Paramount Pictures | - |
| 21 | 25 | +4 | The Last King of Scotland | $300,000 | $292,730 | -$7,270 | -2.4% | 30 | $541,000 | $533,737 | 2 | Fox Searchlight Pictures | - |
| 22 | 28 | +6 | Everyone's Hero | $276,000 | $256,669 | -$19,331 | -7% | 595 | $13,865,000 | $13,846,166 | 4 | Twentieth Century Fox | - |
| 23 | 29 | +6 | Keeping Mum | $208,000 | $191,436 | -$16,564 | -8% | 75 | $563,000 | $545,873 | 4 | THINKFilm | - |
| 24 | 30 | +6 | Hollywoodland | $172,000 | $169,961 | -$2,039 | -1.2% | 283 | $14,274,000 | $14,271,459 | 5 | Focus Features | - |
| 25 | 34 | +9 | Accepted | $152,000 | $145,475 | -$6,525 | -4.3% | 253 | $36,200,000 | $36,193,190 | 8 | Universal Pictures | - |
| 26 | 33 | +7 | Love's Abiding Joy | $145,895 | - | - | - | 207 | $145,895 | - | 1 | The Bigger Picture | - |
| 27 | 38 | +11 | Half Nelson | $130,000 | $122,180 | -$7,820 | -6% | 99 | $2,386,000 | $2,378,723 | 9 | THINKFilm | - |
| 28 | 36 | +8 | The U.S. vs. John Lennon | $130,000 | $129,150 | -$850 | -0.7% | 58 | $553,000 | $551,821 | 4 | Lionsgate | - |
| 29 | 41 | +12 | Shortbus | $121,000 | $107,907 | -$13,093 | -10.8% | 6 | $121,000 | $129,129 | 1 | THINKFilm | - |
| 30 | 42 | +12 | Little Children | $108,000 | $97,953 | -$10,047 | -9.3% | 5 | $108,000 | $97,953 | 1 | New Line Cinema | - |
| 31 | 40 | +9 | Crank | $100,000 | $118,599 | +$18,599 | +18.6% | 164 | $27,753,000 | $27,771,239 | 6 | Lionsgate | - |
| 32 | 44 | +12 | The Protector | $63,100 | $71,647 | +$8,547 | +13.5% | 145 | $11,655,000 | $11,663,169 | 5 | Dragon Dynasty | - |
| 33 | 48 | +15 | A Guide to Recognizing Your Saints | $55,300 | $56,224 | +$924 | +1.7% | 10 | $185,000 | $185,871 | 2 | First Look International | - |
| 34 | 52 | +18 | The Descent | $41,000 | $42,562 | +$1,562 | +3.8% | 89 | $26,004,000 | $26,005,908 | 10 | Lionsgate | - |
| 35 | 64 | +29 | Pulse | $15,200 | $15,157 | -$43 | -0.3% | 39 | $20,259,000 | $20,259,297 | 9 | Dimension Films | - |
| 36 | 71 | +35 | American Hardcore | $10,300 | $9,665 | -$635 | -6.2% | 5 | $74,000 | $73,372 | 3 | Sony Pictures Classics | - |
| 37 | 68 | +31 | Renaissance | $10,000 | $10,412 | +$412 | +4.1% | 13 | $47,000 | $47,213 | 3 | Miramax | - |
