| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Perfume: The Story of a Murderer | $6,718,237 | -30.7% | 773 | +73 | $8,691 | $20,223,858 | 2 | Constantin Film | false | false |
| 2 | 2 | Cars | $1,489,575 | -40.3% | 814 | - | $1,829 | $8,485,200 | 3 | Buena Vista International | false | false |
| 3 | - | You, Me and Dupree | $1,185,839 | - | 348 | - | $3,407 | $1,185,839 | 1 | United International Pictures | true | false |
| 4 | - | Crank | $878,560 | - | 399 | - | $2,201 | $878,560 | 1 | Universum Film (UFA) | true | false |
| 5 | 5 | Grave Decisions | $369,219 | -21.2% | 98 | +1 | $3,767 | $4,016,472 | 6 | Movienet | false | false |
| 6 | - | The Trip to Panama | $348,190 | - | 553 | - | $629 | $348,190 | 1 | Warner Bros. | true | false |
| 7 | 3 | Miami Vice | $263,325 | -51.9% | 398 | -47 | $661 | $9,316,157 | 5 | United International Pictures | false | false |
| 8 | 4 | Pirates of the Caribbean: Dead Man's Chest | $260,859 | -50.6% | 387 | -189 | $674 | $60,592,052 | 9 | Buena Vista International | false | false |
| 9 | - | She's the Man | $138,053 | - | 120 | - | $1,150 | $138,053 | 1 | Kinowelt Filmverleih | true | false |
| 10 | 6 | The Break-Up | $109,259 | -62.9% | 319 | -73 | $342 | $9,642,407 | 7 | United International Pictures | false | false |
| 11 | 8 | Thank You for Smoking | $101,411 | -34.6% | 89 | -2 | $1,139 | $1,156,727 | 4 | 20th Century Fox International | false | false |
| 12 | 11 | Emma's Bliss | $96,507 | -15.9% | 120 | - | $804 | $1,904,985 | 6 | Pandora Filmproduktion | false | false |
| 13 | 7 | Garfield: A Tail of Two Kitties | $95,817 | -48.6% | 459 | -103 | $208 | $7,776,498 | 7 | 20th Century Fox International | false | false |
| 14 | - | Brick | $93,071 | - | 37 | - | $2,515 | $93,071 | 1 | Senator Film | true | false |
| 15 | 9 | Volver | $80,637 | -36% | 111 | -4 | $726 | $5,184,103 | 8 | TOBIS Film | false | false |
